Results 61 to 70 of about 5,820 (221)

Andrographolide Inhibits Nuclear Factor-κB Activation through JNK-Akt-p65 Signaling Cascade in Tumor Necrosis Factor-α-Stimulated Vascular Smooth Muscle Cells

open access: yesThe Scientific World Journal, 2014
Critical vascular inflammation leads to vascular dysfunction and cardiovascular diseases, including abdominal aortic aneurysms, hypertension, and atherosclerosis.
Yu-Ying Chen   +5 more
doaj   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li   +10 more
wiley   +1 more source

Extraction of Diterpenoid Lactones of Andrographis paniculata using Liquid Solvents: Effect of Solvent’s Hildebrand Solubility Parameter on Extraction Efficiency [PDF]

open access: yes, 2006
Two diterpenoid lactones responsible to the multi healing properties of Andrographis paniculata have been extracted using 16 different liquid solvents. The effect of Hildebrand solubility parameter of the solvents on solid-liquid extraction yield using ...
Kumoro, A.C., Hasan, M.
core  

Ribosomal Proteins in Cell Biology and Cancer

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang   +4 more
wiley   +1 more source

Smart Polymer‐Based Drug Delivery Systems for Managing Infective Conjunctivitis: Advances and Future Prospects

open access: yesNano Select, Volume 7, Issue 6, June 2026.
The introduction covers the background and significance of conjunctivitis. It continues with a review of etiology, epidemiology, and clinical manifestations. Diagnostic methods are described, followed by discussions on pathophysiology and classification. Current treatment strategies, preventive measures, and therapeutic challenges are analyzed.
Xia Linkang   +11 more
wiley   +1 more source

Structures of andrographolide (ANDRO, 1) and an NBD-conjugated andrographolide derivative 2 (ANDRO-NBD).

open access: yes, 2016
Structures of andrographolide (ANDRO, 1) and an NBD-conjugated andrographolide derivative 2 (ANDRO-NBD).
Lee-Chiang Lo (1545814)   +7 more
core   +1 more source

Effects of Andrographolide on Mouse Intestinal Microflora Based on High-Throughput Sequence Analysis

open access: yesFrontiers in Veterinary Science, 2021
The intestinal flora is a micro-ecosystem that is closely linked to the overall health of the host. We examined the diversity and abundance of intestinal microorganisms in mice following the administration of andrographolide, a component of the Chinese ...
Haigang Wu   +7 more
doaj   +1 more source

Nanoencapsulation of Essential Oils: A Review of Current Trends and Advances in Preparation, Characterization, and Biomedical Applications

open access: yesNano Select, Volume 7, Issue 6, June 2026.
This review highlights nanoencapsulation as a powerful strategy to improve the stability, solubility, and bioavailability of essential oils. It surveys key EO‐producing plant families, major bioactive constituents, and therapeutic properties, alongside high‐ and low‐energy nanoformulation methods. Applications across pharmaceutical, cosmetic, food, and
Mateusz Guz   +3 more
wiley   +1 more source

Andrographolide inhibits arrhythmias and is cardioprotective in rabbits

open access: yesOncotarget, 2017
Andrographolide has a protective effect on the cardiovascular system. To study its cardic-electrophysiological effects, action potentials and voltage-gated Na+ (INa), Ca2+ (ICaL), and K+ (IK1, IKr, Ito and IKur) currents were recorded using whole-cell patch clamp and current clamp techniques.
Zeng, Mengliu   +8 more
openaire   +2 more sources

Mitochondrial reprogramming in lung cancer: a therapeutic vulnerability and a strategy for reversing drug resistance

open access: yesThe Journal of Pathology, Volume 269, Issue 2, Page 149-163, June 2026.
Abstract The conceptualization of mitochondria, previously restricted to their function as cellular ‘powerhouses’, has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and fate determination.
Woo Hyun Park
wiley   +1 more source

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