Six New Andrographolide Metabolites in Rats
Chemical and Pharmaceutical Bulletin, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
He, Xiangjiu +5 more
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Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives. [PDF]
PLoS ONE, 2013 Anticancer role of andrographolide is well documented. To find novel potent derivatives with improved cytotoxicity than andrographolide on cancer cells, two series of di-spiropyrrolidino- and di-spiropyrrolizidino oxindole andrographolide derivatives ...
Sumit Kumar Dey +10 more
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Biosensors, 2022 Andrographolide is an active diterpenoid compound extracted from Andrographis paniculata. It exhibits antiinflammatory and anticancer effects. Previous studies show that it is non-toxic to experimental animals.
Heng-Yi Liao +6 more
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Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, EarlyView.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
Therapeutic potential of andrographolide for treating endometriosis [PDF]
Human Reproduction, 2012 Mounting evidence shows that nuclear factor-κB (NF-κB) plays an important role in endometriosis. We therefore evaluated the therapeutic potential of andrographolide, an NF-κB inhibitor.Primary cell cultures were performed using ectopic endometrial tissue specimens and their homologous eutopic endometrial specimens from 16 women with endometriosis, as ...
Yu, Zheng, Xishi, Liu, Sun-Wei, Guo
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Experimental and Modeling Studies of Andrographolide Extraction from Andrographis paniculata in a Soxhlet Extractor [PDF]
, 2006 Andrographolide is the main diterpenoid lactone contained in the leaves of Andrographis paniculata. This bioactive component has multifunctional medicinal properties such as activity against fever, dysentery, diarrhoea, inflammation, and sore throat as
Kumoro, A.C., Hasan, M.
core
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus [PDF]
Neural Plasticity, 2015 Andrographolide (ANDRO) is a labdane diterpenoid component ofAndrographis paniculatawidely used for its anti-inflammatory properties. We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase-3β(GSK-3β), a key enzyme of the Wnt/β-catenin signaling cascade.
Varela-Nallar, L. +4 more
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MODELLING OF SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA LEAVES BY EMPLOYING INTEGRAL DESORPTION CONCEPT [PDF]
, 2006 Mathematical formulation is necessary for the optimisation and scale-up of a separation unit such as the extraction of biomolecules from their natural resources.
Kumoro, A.C. +2 more
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The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy
eFood, Volume 7, Issue 3, June 2026.Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu +6 more
wiley +1 more source