Results 41 to 50 of about 4,348 (183)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Therapeutic potential of andrographolide for treating endometriosis [PDF]

Human Reproduction, 2012
Mounting evidence shows that nuclear factor-κB (NF-κB) plays an important role in endometriosis. We therefore evaluated the therapeutic potential of andrographolide, an NF-κB inhibitor.Primary cell cultures were performed using ectopic endometrial tissue specimens and their homologous eutopic endometrial specimens from 16 women with endometriosis, as ...
Yu, Zheng, Xishi, Liu, Sun-Wei, Guo
openaire   +2 more sources

Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus (CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 ...
Swati Gupta, Kamla Prasad Mishra, Paban Kumar Dash, Manmohan Parida, Lilly Ganju, Shashi Bala Singh   +5 more
doaj   +1 more source

Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity. [PDF]

PLoS ONE, 2018
BACKGROUND:Activation of Ras oncogene in human tumors is associated with radiation-associated metastatic potential. Although ionizing radiation is one important method of cancer treatments, it has been shown to enhance matrix metalloproteinases (MMPs ...
Chih-Chia Yu, Chien-An Chen, Shu-Ling Fu, Hon-Yi Lin, Moon-Sing Lee, Wen-Yen Chiou, Yu-Chieh Su, Shih-Kai Hung   +7 more
doaj   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Andrographolide Stimulates Neurogenesis in the Adult Hippocampus [PDF]

Neural Plasticity, 2015
Andrographolide (ANDRO) is a labdane diterpenoid component ofAndrographis paniculatawidely used for its anti-inflammatory properties. We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase-3β(GSK-3β), a key enzyme of the Wnt/β-catenin signaling cascade.
Varela-Nallar, L., Arredondo, S.B., Tapia-Rojas, C., Hancke, J., Inestrosa, N.C.   +4 more
openaire   +6 more sources

Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives. [PDF]

PLoS ONE, 2013
Anticancer role of andrographolide is well documented. To find novel potent derivatives with improved cytotoxicity than andrographolide on cancer cells, two series of di-spiropyrrolidino- and di-spiropyrrolizidino oxindole andrographolide derivatives ...
Sumit Kumar Dey, Dipayan Bose, Abhijit Hazra, Subhendu Naskar, Abhishek Nandy, Rudra Narayan Munda, Subhadip Das, Nabanita Chatterjee, Nirup Bikash Mondal, Sukdeb Banerjee, Krishna Das Saha   +10 more
doaj   +1 more source

Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

Molecules, 2021
Spodoptera litura Fab. is a polyphagous pest causing damage to many agriculture crops leading to yield loss. Recurrent usage of synthetic pesticides to control this pest has resulted in resistance development.
Edward-Sam Edwin, Prabhakaran Vasantha-Srinivasan, Sengottayan Senthil-Nathan, Muthiah Chellappandian, Sengodan Karthi, Radhakrishnan Narayanaswamy, Vethamonickam Stanley-Raja, Haridoss Sivanesh, Ramakrishnan Ramasubramanian, Asma A. Al-Huqail, Faheema Khan, Patcharin Krutmuang, Ahmed Abdel-Megeed, Aml Ghaith, Chae-Hoon Paik   +14 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Andrographolide Inhibits Nuclear Factor-κB Activation through JNK-Akt-p65 Signaling Cascade in Tumor Necrosis Factor-α-Stimulated Vascular Smooth Muscle Cells

The Scientific World Journal, 2014
Critical vascular inflammation leads to vascular dysfunction and cardiovascular diseases, including abdominal aortic aneurysms, hypertension, and atherosclerosis.
Yu-Ying Chen, Ming-Jen Hsu, Cheng-Ying Hsieh, Lin-Wen Lee, Zhih-Cherng Chen, Joen-Rong Sheu   +5 more
doaj   +1 more source