Discovery of ferroelectricity in natural product androstane
Discover Materials, 2023 Progesterone and its derivatives attracted widespread interest because of their applications in medicine, health care and birth control, which is the main active ingredient of contraceptive pills known as one of the five chemistry discoveries that ...
Ren-Gen Xiong +2 more
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Journal of Lipid Research, 1968 The hypocholesterolemic activities of 17amethyltestosterone and its major identified fecal metabolite, 17α-methyl-5α-androstane-3β,17β-diol, were compared in dogs. The dose-response curves indicated that the two compounds had similar effects, although at
Liese L. Abell, Erwin H. Mosbach
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Deciphering the roles of the constitutive androstane receptor in energy metabolism [PDF]
Acta Pharmacologica Sinica, 2014 Jiong Yan, Baian Chen, Jing Lu
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The Pivotal Role of GR-CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood. [PDF]
Adv Sci (Weinh)Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Sun X +9 more
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Constitutive androstane receptor, liver pathophysiology and chemical contaminants: current evidence and perspectives [PDF]
Frontiers in EndocrinologyIntroductionThe Constitutive Androstane Receptor (CAR) (NR1I3), a pivotal member of the xenosensor family, plays a key role in the hepatic detoxification of xenobiotic and endobiotic chemicals through the induction of the expression of drug-metabolizing ...
Francesca De Battistis +4 more
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Overcoming the Challenge of Confident Identification Among Two Related Groups of 17-Methyl Steroids by GC-MS. [PDF]
J Sep SciABSTRACT Tetrahydromethyltestosterone (THMT) and 20‐hydroxymethyl‐18‐nortetrahydromethyltestosterone (20OHnorTHMT) are metabolites of the anabolic androgenic steroids methyltestosterone and metandienone. Both molecular structures are used as markers in anti‐doping analysis. There are eight reasonable diastereomeric structures of each group relevant for
Steff J, Torre X, Botrè F, Parr MK.
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Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes [PDF]
Journal of Biological Chemistry, 2003 Millard H Lambert
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Constitutive Androstane Receptor in Macrophages Regulates Toll-Like Receptor 4-Mediated Innate Immune Responses Against Endotoxemic Liver Injury. [PDF]
Adv Sci (Weinh)The present study uncovers a novel role of constitutive androstane receptor (CAR) in inflammation‐mediated damage. CAR activation in macrophages inhibits proinflammatory macrophages by interacting with Tlr4, which protects against endotoxemic liver injury.
Cao R +12 more
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Molecules, 2021 Glucose 6-phosphate dehydrogenase (G6PDH) fulfills an essential role in cell physiology by catalyzing the production of NADPH+ and of a precursor for the de novo synthesis of ribose 5-phosphate.
Cecilia Ortíz +5 more
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Magnetochemistry, 2020 The combination of an androstane-3,17-diol nucleus and a 2β-N-alkylamidopiperazino sidechain is important for the anticancer activity of a new family of steroid derivatives.
Donald Poirier +3 more
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