Results 221 to 230 of about 17,064 (267)
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Pharmacogenetics of the Constitutive Androstane Receptor
Pharmacogenomics, 2007The constitutive androstane receptor (CAR), a member of the NR1I group of nuclear hormone receptors, has been implicated in regulating the expression of genes that are critical in xenobiotic and endobiotic metabolism, uptake and elimination as well as genes involved in various other physiological processes. Hence, functional variation in CAR associated
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
Significant metabolism of 5 alpha-androstane-3 beta,17 beta-diol to 17 beta-hydroxy-5 alpha-androstan-3-one was recorded in several tissues and organs from rats and humans. This bioconversion was further investigated in rat testis homogenates. 5 alpha-Androstane-3 beta,17 beta-diol was readily metabolized to 17 beta-hydroxy-5 alpha-androstan-3-one with
Arne Sunde +2 more
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Significant metabolism of 5 alpha-androstane-3 beta,17 beta-diol to 17 beta-hydroxy-5 alpha-androstan-3-one was recorded in several tissues and organs from rats and humans. This bioconversion was further investigated in rat testis homogenates. 5 alpha-Androstane-3 beta,17 beta-diol was readily metabolized to 17 beta-hydroxy-5 alpha-androstan-3-one with
Arne Sunde +2 more
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Radioimmunoassays for androsterone, 5α-androstane-3α,17β-diol and 5α-androstane-3β,17β-diol
Steroids, 1977Abstract Androsterone (3α-hydroxy-5α-androstan-17-one), 5α-androstane-3α, 17β-diol and 5α-androstane-3β,17B-diol were conjugated at C-16 through sulfur to bovine and human serum albumin. Rabbits injected with these conjugates produced antibodies suitable for radioimmunoassays of these hormone metabolites.
J ZAMECNIK +3 more
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The synthesis of (–)-sandaracopimaradiene from androstane derivatives
J. Chem. Soc. C, 1966The conversion of testosterone and 3β-hydroxyandrost-5-en-17-one into the diterpene sandaracopimaradiene is described. 4,4-Dimethyl-5α-androst-14-ene and its 17β-hydroxy-derivative were prepared by acid-catalysed isomerisation of the 5,7-dienes, hydrogenation, and further isomerisation of the resulting 8(14)-olefins.
P, Johnston +3 more
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Androstane and Withanolides fromPhysalis cinerascens
Planta Medica, 2005Two new withanolides, cinerolide and 24,25-dihydrowithanolide S, together with the new androstane, cinedione, and the known withanolides, visconolide, physalactone, withanolide S and 4beta-hydroxywithanolide E were isolated from the EtOAc extract of leaves, flowers and stems of Physalis cinerascens. The structures of these compounds were established by
Emma, Maldonado +4 more
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Substituted androstanes as aromatase inhibitors
Russian Chemical Reviews, 1998The synthesis and structure–activity relationships of inhibitors of steroid aromatase which catalyses the last stage of a multistep biotransformation of cholesterol into estrogens, viz., aromatisation of C19-steroids into C18-phenolic steroids, are discussed.
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Steroids, 1978
Androsterone (3alpha-hydroxy-5alpha-androstan-17-one), 5alpha-androstane-3alpha, 17beta-diol and 5alpha-androstane-3beta, 17beta-diol were conjugated at C-16 through sulfur to bovine and human serum albumin. Rabbits injected with these conjugates produced antibodies suitable for radioimmunoassays of these hormone metabolites.
J, Zamecnik +3 more
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Androsterone (3alpha-hydroxy-5alpha-androstan-17-one), 5alpha-androstane-3alpha, 17beta-diol and 5alpha-androstane-3beta, 17beta-diol were conjugated at C-16 through sulfur to bovine and human serum albumin. Rabbits injected with these conjugates produced antibodies suitable for radioimmunoassays of these hormone metabolites.
J, Zamecnik +3 more
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