Results 21 to 30 of about 17,064 (267)

Chromatographic lipophilicity as a predictor of antiproliferative activity of 17-picolyl and 17-picolinylidene androstane derivatives toward prostate cancer [PDF]

Acta Periodica Technologica, 2015
The present study describes the quantitative retention - (anticancer) activity relationship analysis of a series of 17-picolyl and 17-picolinylidene androstane derivatives based on the chromatographic data obtained by reversed-phase high ...
Kovačević Strahinja Z., Podunavac-Kuzmanović Sanja O., Jevrić Lidija R., Đurendić Evgenija A., Ajduković Jovana J., Jovanov Pavle T.   +5 more
doaj   +1 more source

Computational modeling of distribution coefficients and their correlations with pharmacokinetic properties of 17α-picolyl and 17(E)-picolinylidene androstane derivatives [PDF]

Acta Periodica Technologica, 2019
The present study describes the computational modeling of distribution coefficient (logD) of 17α-picolyl and 17(E)-picolinylidene androstane derivatives, as a group of compounds with significant anticancer activities.
Kovačević Strahinja Z., Karadžić-Banjac Milica Ž., Podunavac-Kuzmanović Sanja O., Ajduković Jovana J.   +3 more
doaj   +1 more source

Reactivity of 17β-hydroxy-17α-substituted androstane derivatives [PDF]

Acta Periodica Technologica, 2010
The work concerns the reactivity of 17β-hydroxy-17α-substituted androstanes 1-9. Depending on the nature of the 17α-substituent, the presence of the neighboring 16-oximino group, and the reagent used, these compounds can undergo retroaddition (10-12 ...
Penov-Gaši Katarina M., Gaković Andrea R., Ajduković Jovana J., Đurendić-Brenesel Maja Đ., Đurendić Evgenija A., Savić Marina P., Sakač Marija N.   +6 more
doaj   +1 more source

Addressing new chemicals of emerging concern (CECs) in an indoor office

Environment International, 2023
Indoor pollutants change over time and place. Exposure to hazardous organics is associated with adverse health effects. This work sampled gaseous organics by Tenax TA tubes in two indoor rooms, i.e., an office set as samples, and the room of chassis ...
Kai Song, Xinping Yang, Yunjing Wang, Zichao Wan, Junfang Wang, Yi Wen, Han Jiang, Ang Li, Jingshun Zhang, Sihua Lu, Baoming Fan, Song Guo, Yan Ding   +12 more
doaj   +1 more source

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides, and Their Effect on the 5α-Reductase Isoform 2, the Androgen Receptor, and Androgen-Dependent Glands [PDF]

Pharmaceutical Sciences, 2022
Background: Benign Prostatic Hyperplasia (BPH), and Prostate Cancer (PCa) are androgen-dependent diseases. PPCa is associated with excessive signalling of the androgen receptor (AR) due to the binding of 5α-dihydrotestosterone (5α-DHT) and testosterone ...
Juan C. Lopez-Lezama, Marisa Cabeza, Yvonne Heuze, Araceli Sánchez, José L. Rojas, Norma A. Valencia-Islas   +5 more
doaj   +1 more source

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]

, 2008
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Anja Rode, Baes, Bauer, Branko Zevnik, C. Roland Wolf, Dotzlaw, Forrester, Hustert, Jillian Ross, Kocarek, Lowry, Lukas, Meehan, Nico Scheer, Nicole Faust, Poland, Sandra Niehaves, Smith, Wolf, Wrighton   +19 more
core   +4 more sources

Changes in aliphatic hydrocarbon tracer composition during the digestive process of the marine worm Nereis virens. Preliminary results [PDF]

, 1998
In the laboratory, marine worms were fed with a mixture of algae and several aliphatic hydrocarbons for 15 days. By comparing hydrocarbons in food and in faeces, it appeared that the worm's digestive process led to changes in the distribution of the n ...
Atlas, Bauer, Blumer, Forbes, Gardner, Gilbert, Gilbert, Gordon, Karickhoff, Leahy, Lee, Lee, McElroy, McElroy, Myers, Olivier, Plante, Reynoldson, Steinhauer   +18 more
core   +4 more sources

Searching for Constitutive Androstane Receptor Modulators [PDF]

Drug Metabolism and Disposition, 2022
The constitutive androstane receptor (CAR; NR1I3) has been established as one of the main drug- and xenobiotic-responsive transcriptional regulators, collectively called xenosensors. CAR activates the expression of several oxidative, hydrolytic, and conjugative drug-metabolizing enzymes and drug transporters, and therefore, it contributes to drug and ...
openaire   +2 more sources

Antimicrobial Activity of Nitrogen-Containing 5-α-Androstane Derivatives: In Silico and Experimental Studies

Antibiotics, 2020
We evaluated the antimicrobial activity of thirty-one nitrogen-containing 5-α-androstane derivatives in silico using computer program PASS (Prediction of Activity Spectra for Substances) and freely available PASS-based web applications (such as Way2Drug).
Lela Amiranashvili, Nanuli Nadaraia, Maia Merlani, Charalampos Kamoutsis, Anthi Petrou, Athina Geronikaki, Pavel Pogodin, Dmitry Druzhilovskiy, Vladimir Poroikov, Ana Ciric, Jasmina Glamočlija, Marina Sokovic   +11 more
doaj   +1 more source

Detection of Anabolic Androgenic Steroids and Steroid Esters-Comparing Dried Blood Spots Collection Devices and Urine Samples. [PDF]

Drug Test Anal
DBS (Capitainer‐B50 and Tasso‐M20) enabled detection of testosterone esters in all participants, whereas urine testing (T/E) missed cases including potential UGT2B17 del/del carriers and individuals with testosterone prescription. More AAS and steroid‐esters could be detected in Capitainer‐B50 versus Tasso‐M20.
Suominen T, von Walden J, Harju L, Pohanka A, Schulze J, Lehtihet M, Ekström L.   +6 more
europepmc   +2 more sources