Canvass: a crowd-sourced, natural-product screening library for exploring biological space [PDF]
, 2018 NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A.
Andrade, Rodrigo B. +94 more
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Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. [PDF]
, 2008 The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification.
Finn, Robert +3 more
core +4 more sources
Identification of the fecal metabolites of 17α-methyltestosterone in the dog
Journal of Lipid Research, 1968 1 7α-Methyltestosterone-4-14C was fed to two dogs in an experiment to determine tissue localization and metabolic disposition of this hypocholesterolemic steroid.
Erwin H. Mosbach +2 more
doaj +1 more source
2a,3a-Dihydroxyandrostan-16-one
Acta Crystallographica Section E, 2009 The title compound, C19H28O4, is a new androstane steroid derivative. In the crystal, molecules are linked along the a axis by intermolecular O—H...O hydrogen bonds.
Li Zhang +3 more
doaj +1 more source
Non-targeted LC-MS based metabolomics analysis of the urinary steroidal profile [PDF]
, 2017 The urinary steroidal fraction has been extensively explored as non-invasive alternative to monitor pathological conditions as well as to unveil the illicit intake of pseudo-endogenous anabolic steroids in sport.
Botrè, Francesco +3 more
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3D model of amphioxus steroid receptor complexed with estradiol [PDF]
, 2009 The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates.
David J. Chang, Michael E. Baker
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Development and validation of a fast gas chromatography combustion isotope ratio mass spectrometry method for the detection of epiandrosterone sulfate in urine [PDF]
, 2020 In doping control, to confirm the exogenous origin of exogenously administered anabolic androgenic steroids (AAS), a gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS) analysis is performed.
De Wilde, Laurie +3 more
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The International Journal of Biological Markers, 1999 Urinary androstanediol measurement, often in association with other androgens, is commonly used to support the clinical diagnosis of idiopathic hirsutism.
G.J. Minut +4 more
doaj +1 more source
STAR Protocols, 2021 Summary: Here, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation of ...
Alexandre Berthier +2 more
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Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in earlyand late-stage cholestasis [PDF]
, 2017 AIM: To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Albertoni, Laura +9 more
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