Results 41 to 50 of about 17,064 (267)

Androstane-3β,5α,6β,17β-tetrol trihydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
The title hydrated tetrol, C(19)H(32)O(4)·3H(2)O, was synthesized by stereoselective reduction of the compound 3β,5α,6β-trihy-droxy-androstan-17-one. All rings are fused trans. The organic mol-ecules are connected head-to-tail along the c axis via O-H⋯O hydrogen bonds. Layers of water mol-ecules in the ab plane inter-connect these chains.
Andrade, L. C. R., Almeida, M. J. B. M. de, Paixão, J. A., Carvalho, J. F. S., Melo, M. L. Sá e   +4 more
openaire   +3 more sources

Hepatic metabolism of short-chain bile acids. Inversion of the 3-hydroxyl group of isoetianic acid (3 beta-hydroxy-5 beta-androstane-17 beta-carboxylic acid) by the adult rat.

Journal of Lipid Research, 1991
The stereospecificity of mechanisms for hepatic transport of short-chain bile acids has been examined by following the hepatic metabolism and biliary secretion of 3 beta-hydroxy-5 beta-androstane-17 beta-carboxylic acid (isoetianic acid) administered in ...
JM Little, JS Pyrek, A Radominska, KE Shattuck, R Lester   +4 more
doaj   +1 more source

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells [PDF]

, 2017
open12noBreast cancer (BC) is one of the major causes of cancer death in women and is closely related to hormonal dysregulation. Estrogen receptor (ER)-positive BCs are generally treated with anti hormone therapy using antiestrogens or aromatase ...
CARRA, Serena, Cicardi, Maria Elena, Crippa, Valeria, Cristofani, Riccardo, Ferri, Nicola, Galbiati, Mariarita, Meroni, Marco, Messi, Elio, MORELLI, FEDERICA FRANCESCA, Piccolella, Margherita, Poletti, Angelo, Rusmini, Paola   +11 more
core   +3 more sources

Clinical Relevance of the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2022
Constitutive androstane receptor (CAR) (NR1I3), a xenobiotic receptor, has long been considered a master mediator of drug disposition and detoxification. Accumulating evidence indicates that CAR also participates in various physiologic and pathophysiological pathways regulating the homeostasis of glucose, lipid, and bile acids, and contributing to cell
Sydney, Stern, Ritika, Kurian, Hongbing, Wang   +2 more
openaire   +2 more sources

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases [PDF]

, 2004
Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of ...
Atsuta J, Boner AL, Bridgman A, Callen J, Delescluse J, Dooms-Goossens AE, Dykes PJ, Falcoz C, Fisher DA, Goossens A, Harding SM, Hogger P, James M, Johnson M, Johnson M, Juhlin L, Katz HI, Korting HC, Lebwohl M, Li JT, Liu XQ, Llewellyn-Jones CG, Lucky AW, McKenzie AW, McLean HM, Nurnberger FG, Phillipps GH, Roberts DT, Spencer CM, Tharp MD, Venning VA, Wilkinson SM, Wolkerstorfer A, Young MMR   +33 more
core   +1 more source

Steroid substrate-induced epimerase mechanism in the active site of the human 11β-hydroxysteroid dehydrogenase type 1 [PDF]

, 2008
Cytochrome P4507B1 7[alpha]-hydroxylates dehydroepiandrosterone (DHEA), epiandrosterone (EpiA) and 5[alpha]-androstane-3[beta],17[beta]-diol (Adiol). 11[beta]-Hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) interconverts 7[alpha]- and 7[beta]- forms.
Alain Favre-Reguillon, Clotilde Ferroud, Henry Chermette, Matthieu Montes, Olivier Hennebert, Robert Morfin   +5 more
core   +2 more sources

Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms [PDF]

, 2012
BACKGROUND AND PURPOSE Widespread resistance to antimalarial drugs requires combination therapies with increasing risk of pharmacokinetic drugdrug interactions.
Alexander, Arnold, Asimus, Auerbach, Auerbach, Baes, Berman, Blättler, Burk, Burk, di Masi, Dring, Elsherbiny, Faucette, Gautam, Giao, Grace, Halgren, Hesse, Hoffart, Honda, Huey, Hustert, Jyrkkärinne, Kawamoto, Kerb, Khoo, Krey, Kyle, Lee, Maglich, Moore, Morris, Navaratnam, Nussler, Pan, Pissios, Ross, Sanner, Simonsson, Skinner-Adams, Svensson, Svärd, Wang, Ward, White, WHO, WHO, Windshügel, Wolbold, Xu, Zhang   +51 more
core   +1 more source

Alteration and release of aliphatic compounds by the polychaete Nereis virens (Sars) experimentally fed with hydrocarbons [PDF]

, 2001
In the laboratory, marine worms were fed with a mixture of algae and several aliphatic hydrocarbons for 15 days. After ingestion by the worms, 34.9% of hydrocarbons are found in the faeces and only 3.1% accumulated in the gut.
Bertrand, Jean-Claude, Deflandre, Bruno, Desrosiers, Gaston, Gagne, Jean-Pierre, Gilbert, Franck, Poggiale, Jean-Christophe, Stora, Georges   +6 more
core   +4 more sources

Modulation of Xenobiotic Receptors by Steroids

Molecules, 2013
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic ...
Delira Robbins, Monimoy Banerjee, Taosheng Chen   +2 more
doaj   +1 more source

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

Cells, 2020
During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules ...
Jenni Küblbeck, Jonna Niskanen, Paavo Honkakoski   +2 more
doaj   +1 more source