Results 61 to 70 of about 17,064 (267)
Experimental Physiology, EarlyView.Abstract Altitude training enhances haematological adaptations and endurance at sea level, typically requiring exposure to ∼2500 m altitude for 3–4 weeks. Emerging evidence suggests that low‐dose carbon monoxide (CO) inhalation might mimic hypoxia and might be used by elite athletes.
Simone Villanova +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
17β-Hydroxy-2-oxa-5α-androstan-3-one
MolbankWe have successfully synthesized a 2-oxa androstane derivative, 17β-hydroxy-2-oxa-5α-androstan-3-one (6), and confirmed its structure using NMR spectroscopy and mass spectrometry.
Savina Stoyanova +2 more
doaj +1 more source
Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim +4 more
wiley +1 more source
Secondary metabolites with ecologic and medicinal implications in Anthemis cretica subsp. petraea from Majella National Park [PDF]
, 2016 Anthemis cretica subsp. petraea (Ten.) Greuter is a plant belonging to the Asteraceae family and endemic of central Italy. In this paper, the first analysisof the ethanolic fraction of samples collected in the Majella National Park is reported.
Alessandro Venditti +7 more
core +2 more sources
The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith +4 more
wiley +1 more source
Impact of Neonatal Manipulation of Androgen Receptor Function on Endocrine-Metabolic Programming in the Juvenile Female Rat [PDF]
, 2013 The impact of neonatal androgen receptor (AR) stimulation/blockage, due to testosterone propionate (TP)/AR antagonist treatment, on individual anthropometry and neuroendocrine-metabolic function was evaluated in the juvenile female rat. Pups (age 5 days)
Giovambattista, Andres +2 more
core +3 more sources
Biologia Plantarum, 2010 The effect of foliar spray with 10-12 M aqueous solutions of 24-epibrassinolide or a synthetic androstane analogue of castasterone on the activity of photosystem (PS) 1, the Hill reaction activity, the content of photosynthetic pigments and the specific ...
M. Kočová +4 more
doaj +1 more source
Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]
, 2009 In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho +3 more
core +1 more source
Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver [PDF]
, 2017 Predicting the impact of human exposure to chemicals such as pharmaceuticals and agrochemicals requires the development of reliable and predictive biomarkers suitable for the detection of early events potentially leading to adverse outcomes.
Dubost, Valérie +20 more
core +2 more sources