Results 81 to 90 of about 17,064 (267)
In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver [PDF]
, 2011 Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Ekstrand, Bo +2 more
core +1 more source
EFSA Journal, Volume 23, Issue 12, December 2025.Abstract Amphibians (specifically Xenopus laevis) are used as the model species to assess potential endocrine‐disrupting properties in non‐mammalian species through thyroid modality. The amphibian metamorphosis assay is the most frequently available test.
European Food Safety Authority (EFSA) +17 more
wiley +1 more source
Molecules, 2013 We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT ...
Donald Poirier +3 more
doaj +1 more source
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]
, 2017 Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core +2 more sources
Molecular Oncology, Volume 19, Issue 11, Page 3035-3059, November 2025.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.
Beilstein Journal of Organic Chemistry, 2019 Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity.
Annika Stein +4 more
doaj +1 more source
A brief history of the discovery of PXR and CAR as xenobiotic receptors
Acta Pharmaceutica Sinica B, 2016 The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998.
Jiong Yan, Wen Xie
doaj +1 more source
Polychlorinated Androstanes from the Burrowing Sponge Cliona nigricans [PDF]
Organic Letters, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
E. FATTORUSSO E. +7 more
openaire +3 more sources
The metabolism of anabolic-androgenic steroids in the greyhound
, 2013 BACKGROUND Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity.
Ambrus, Joseph I. +8 more
core +1 more source
Detection of a Single Microdose of Testosterone and Recombinant EPO in Healthy Volunteers
Drug Testing and Analysis, Volume 17, Issue 11, Page 2220-2227, November 2025.Exogenous T was detected with IRMS regardless of T/E elevation—high serum T indicative for IRMS. rhEPO was detected in urine for 72 h in ITP and CP, and Tasso showed less sensitivity than previous DBS devices tested. ABSTRACT Doping with testosterone (T) and erythropoietin (EPO) in low doses (micro‐doping) is a challenge to detect.
Carmel Heiland +5 more
wiley +1 more source