Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes [PDF]
Frontiers in Molecular Neuroscience, 2020 The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds 1-9) to influence the functional activity of inhibitory glycine and γ-aminobutyric acid (GABA) receptors was estimated.
Paulo Sávio Angeiras De Goes +2 more
exaly +5 more sources
Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L. [PDF]
Beilstein Journal of Organic Chemistry, 2019 Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity.
Annika Stein +4 more
doaj +5 more sources
Neurosteroid enantiomers as potentially novel neurotherapeutics. [PDF]
Neurosci Biobehav Rev, 2023 Endogenous neurosteroids and synthetic neuroactive steroids (NAS) are important targets for therapeutic development in neuropsychiatric disorders.
Covey DF +5 more
europepmc +3 more sources
Resistance to androstanes as an approach for androstandienedione yield enhancement in industrial mycobacteria [PDF]
Journal of Industrial Microbiology and Biotechnology, 2003 C. Pérez +6 more
exaly +3 more sources
New Insights into the Metabolism of Methyltestosterone and Metandienone: Detection of Novel A-Ring Reduced Metabolites. [PDF]
Molecules, 2021 Metandienone and methyltestosterone are orally active anabolic-androgenic steroids with a 17α-methyl structure that are prohibited in sports but are frequently detected in anti-doping analysis.
Loke S +10 more
europepmc +3 more sources
Steroidogenic pathway in girls diagnosed with autism spectrum disorders. [PDF]
PLoS ONEThe diagnostic prevalence of autism spectrum disorders (ASD) shows boys to be more affected than girls. Due to this reason, there is a lack of research including and observing ASD girls.
Katarina Jansakova +8 more
doaj +2 more sources
Polychlorinated Androstanes from the Burrowing SpongeCliona nigricans
Organic Letters, 2004 Two new steroidal derivatives, named clionastatins A and B, have been isolated from the burrowing sponge Cliona nigricans. These molecules are tri-and tetrachlorinated androstane derivatives, respectively, and they represent the first polyhalogenated ...
Orazio Taglialatela-scafati +2 more
exaly +2 more sources
Influence of Indomethacin on Steroid Metabolism: Endocrine Disruption and Confounding Effects in Urinary Steroid Profiling of Anti-Doping Analyses. [PDF]
Metabolites, 2020 Anabolic androgenic steroids (AAS) are prohibited as doping substances in sports by the World Anti-Doping Agency. Concentrations and concentration ratios of endogenous AAS (steroid profile markers) in urine samples collected from athletes are used to ...
Stoll A +6 more
europepmc +3 more sources
The analysis of chromatographic behavior of homoandrostane derivatives in reversed-phase ultra-high performance liquid chromatography [PDF]
Acta Periodica Technologica, 2021 Homoandrostane derivatives, as compounds with significant bioactivity, were studied in terms of their chromatographic behavior in reversed-phase ultra-high performance liquid chromatography (RP-UHPLC).
Kovačević Strahinja +9 more
doaj +1 more source
A very efficient bioconversion of soybean phytosterols mixtures to androstanes by mycobacteria
Journal of Industrial Microbiology and Biotechnology, 2006 C. Pérez +4 more
exaly +2 more sources