Results 1 to 10 of about 5,156 (193)

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR [PDF]

Cells, 2020
During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules ...
Jenni Küblbeck, Jonna Niskanen, Paavo Honkakoski   +2 more
doaj   +10 more sources

Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation [PDF]

Molecules, 2020
Constitutive androstane receptor (CAR) activation has found to ameliorate diabetes in animal models. However, no CAR agonists are available clinically. Therefore, a safe and effective CAR activator would be an alternative option.
Shin-Hun Juang, Min-Tsang Hsieh, Pei-Ling Hsu, Ju-Ling Chen, Hui-Kang Liu, Fong-Pin Liang, Sheng-Chu Kuo, Chen-Yuan Chiu, Shing-Hwa Liu, Chen-Hsi Chou, Tian-Shung Wu, Hsin-Yi Hung   +11 more
doaj   +6 more sources

Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor [PDF]

Cells, 2020
Xenobiotic nuclear receptors (NR) are intracellular players involved in an increasing number of physiological processes. Examined and characterized in peripheral organs where they govern metabolic, transport and detoxification mechanisms, accumulating ...
Fabiana Oliviero, Céline Lukowicz, Badreddine Boussadia, Isabel Forner-Piquer, Jean-Marc Pascussi, Nicola Marchi, Laila Mselli-Lakhal   +6 more
doaj   +7 more sources

Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation [PDF]

Acta Pharmaceutica Sinica B, 2021
The constitutive androstane receptor (CAR, NR3I1) belongs to nuclear receptor superfamily. It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown.
Yue Gao, Shicheng Fan, Hua Li, Yiming Jiang, Xinpeng Yao, Shuguang Zhu, Xiao Yang, Ruimin Wang, Jianing Tian, Frank J. Gonzalez, Min Huang, Huichang Bi   +11 more
doaj   +4 more sources

Noncanonical Constitutive Androstane Receptor Signaling in Gene Regulation. [PDF]

Int J Mol Sci, 2020
The constitutive androstane receptor (CAR, NR1I3) is extremely important for the regulation of many physiological processes, especially xenobiotic (drug) metabolism and transporters. CAR differs from steroid hormone receptors in that it can be activated using structurally unrelated chemicals, both through direct ligand-binding and ligand-independent ...
Pustylnyak YA, Gulyaeva LF, Pustylnyak VO.   +2 more
europepmc   +5 more sources

Constitutive androstane receptor, liver pathophysiology and chemical contaminants: current evidence and perspectives [PDF]

Frontiers in Endocrinology
IntroductionThe Constitutive Androstane Receptor (CAR) (NR1I3), a pivotal member of the xenosensor family, plays a key role in the hepatic detoxification of xenobiotic and endobiotic chemicals through the induction of the expression of drug-metabolizing ...
Francesca De Battistis, Aleksandra Buha Djordjevic, Luciano Saso, Alberto Mantovani, Alberto Mantovani   +4 more
doaj   +2 more sources

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

PLoS ONE, 2014
The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel   +6 more
doaj   +3 more sources

Constitutive Androstane Receptor in Macrophages Regulates Toll‐Like Receptor 4‐Mediated Innate Immune Responses Against Endotoxemic Liver Injury [PDF]

Advanced Science
Macrophage proinflammatory hyperactivation drives the pathogenesis of acute liver injury, a common complication of sepsis. The role of the nuclear receptor constitutive androstane receptor (CAR) in endotoxin‐induced liver injury remains unclear.
Renjie Cao, Tingting Zhao, Ying Wang, Shaofei Song, Yuan Li, Mengling Hou, Yanxin Zhang, Sengpeng Wong, Siqi Wang, Yuran Wang, Hong Peng, Min Huang, Yiming Jiang   +12 more
doaj   +2 more sources

Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt‐Foxo1 Pathway [PDF]

Advanced Science
Male sexual function can be disrupted by exposure to exogenous compounds that cause testicular physiological alterations. The constitutive androstane receptor (Car) is a receptor for both endobiotics and xenobiotics involved in detoxification.
Mélusine Monrose, Hélène Holota, Guillaume Martinez, Christelle Damon‐Soubeyrand, Laura Thirouard, Emmanuelle Martinot, Edwige Battistelli, Angélique deHaze, Stéphanie Bravard, Christelle Tamisier, Françoise Caira, Charles Coutton, Anne‐Laure Barbotin, Angèle Boursier, Laila Lakhal, Claude Beaudoin, David H. Volle   +16 more
doaj   +2 more sources

Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity [PDF]

Scientific Reports, 2022
Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear receptors. CAR and PXR are encoded by genetically polymorphic NR1I2 and NR1I3, respectively.
Zelalem Petros, Abiy Habtewold, Eyasu Makonnen, Eleni Aklillu   +3 more
doaj   +2 more sources