Results 21 to 30 of about 5,156 (193)

Constitutive androstane receptor regulates the intestinal mucosal response to injury [PDF]

British Journal of Pharmacology, 2017
Background and PurposeThe pathogenesis of the inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), involves aberrant interactions between a genetically susceptible individual, their microbiota and environmental factors.
Grace M Hudson, Kyle L Flannigan, Sarah L Erickson, Fernando A Vicentini, Alexandra Zamponi, Christina L Hirota, Laurie Alston, Christophe Altier, Subrata Ghosh, Kevin P Rioux, Sridhar Mani, Thomas K Chang, Simon A Hirota   +12 more
openaire   +4 more sources

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor

PLoS ONE, 2014
Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X ...
PLOS ONE (2189197)
doaj   +4 more sources

The constitutive androstane receptor and pregnane X receptor in the brain. [PDF]

Br J Pharmacol, 2020
Since their discovery, the orphan nuclear receptors constitutive androstane receptor (CAR;NR1I3) and pregnane X receptor (PXR;NR1I2) have been regarded as master regulators of drug disposition and detoxification mechanisms. They regulate the metabolism and transport of endogenous mediators and xenobiotics in organs including the liver, intestine and ...
Torres-Vergara P, Ho YS, Espinoza F, Nualart F, Escudero C, Penny J.   +5 more
europepmc   +4 more sources

Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver. [PDF]

J Endocr Soc, 2022
Supplemental Data and Figures for:Title:Deletion of constitutive androstane receptor led to intestinal alterations and increased imidacloprid in murine liver. Authors:Anushna Sen1,2, Madison Goforth2,3, Kerry K. Cooper3, and Sayeepriyadarshini Anakk1,2,3,
Sen A, Goforth M, Cooper KK, Anakk S.
europepmc   +2 more sources

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2. [PDF]

Clin Pharmacol Ther, 2021
Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4.
Bachmann F, Duthaler U, Meyer Zu Schwabedissen HE, Puchkov M, Huwyler J, Haschke M, Krähenbühl S.   +6 more
europepmc   +2 more sources

An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells

STAR Protocols, 2021
Summary: Here, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation of ...
Alexandre Berthier, Bart Staels, Philippe Lefebvre   +2 more
doaj   +1 more source

Searching for Constitutive Androstane Receptor Modulators [PDF]

Drug Metabolism and Disposition, 2022
The constitutive androstane receptor (CAR; NR1I3) has been established as one of the main drug- and xenobiotic-responsive transcriptional regulators, collectively called xenosensors. CAR activates the expression of several oxidative, hydrolytic, and conjugative drug-metabolizing enzymes and drug transporters, and therefore, it contributes to drug and ...
openaire   +2 more sources

Activation of the Constitutive Androstane Receptor by Monophthalates [PDF]

Chemical Research in Toxicology, 2016
Humans in industrialized areas are continuously exposed to phthalate plasticizers, prompting concerns of their potential toxicities. Previous studies from our laboratory and others have shown that various phthalates activate several mammalian nuclear receptors, in particular the constitutive androstane receptor (CAR), the pregnane X receptor (PXR), and
Elizabeth M, Laurenzana, Denise M, Coslo, M Veronica, Vigilar, Anthony M, Roman, Curtis J, Omiecinski   +4 more
openaire   +2 more sources

Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR)

Frontiers in Pharmacology, 2021
The induction potentials of ligand-activated nuclear receptors on metabolizing enzyme genes are routinely tested for new chemical entities. However, regulations of drug transporter genes by the nuclear receptor ligands are underappreciated, especially in
Congrong Niu, Bill Smith, Yurong Lai
doaj   +1 more source

MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. [PDF]

PLoS ONE, 2012
Constitutive androstane receptor (CAR) is a nuclear receptor that regulates the transcription of target genes, including CYP2B and 3A. Phenobarbital activates CAR, at least in part, in an AMP-activated protein kinase (AMPK)-dependent manner. However, the
Ryota Shizu, Sawako Shindo, Takemi Yoshida, Satoshi Numazawa   +3 more
doaj   +1 more source