Signaling control of the constitutive androstane receptor (CAR) [PDF]
Protein & Cell, 2014 The constitutive androstane receptor (CAR, NR1I3) plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes. Different from prototypical nuclear receptors, CAR can be activated by either direct ligand binding or ligand-independent (indirect ...
Yang, Hui, Wang, Hongbing
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AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors
Cells, 2023 Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors.
Leonida Rakateli +2 more
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Modulation of Xenobiotic Receptors by Steroids
Molecules, 2013 Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic ...
Delira Robbins +2 more
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A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]
, 2008 The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Zevnik, Branko +13 more
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Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]
, 2010 Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
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The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]
, 2004 BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Urs A Meyer +26 more
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Induction of bilirubin clearance by the constitutive androstane receptor (CAR) [PDF]
Proceedings of the National Academy of Sciences, 2003 Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is particularly common in neonates. Elevated bilirubin levels can be decreased by treatment with phenobarbital. Because the nuclear hormone receptor constitutive androstane receptor (CAR) mediates hepatic effects of this ...
Wendong, Huang +6 more
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Mechanistic studies of the phenobarbital-type induction of cytochromes P450 : role of AMP-activated protein kinase [PDF]
, 2007 Inside the liver cells there are sophisticated mechanisms that have evolved over millions of years to metabolize toxic substances, many of which are fat-soluble compounds making them difficult for the body to excrete.
Blättler, Sharon
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F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
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The Environmental Estrogen, Nonylphenol, Activates the Constitutive Androstane Receptor [PDF]
Toxicological Sciences, 2007 Nonylphenol (NP) and its parent compounds, the nonylphenol ethoxylates are some of the most prevalent chemicals found in U.S. waterways. NP is also resistant to biodegradation and is a known environmental estrogen, which makes NP a chemical of concern.
Juan P, Hernandez +5 more
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