Results 31 to 40 of about 4,340 (154)
Modulation of Xenobiotic Receptors by Steroids
Molecules, 2013 Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic ...
Delira Robbins +2 more
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PLoS ONE, 2014 The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs +6 more
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F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
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F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
doaj +1 more source
Induction of bilirubin clearance by the constitutive androstane receptor (CAR) [PDF]
Proceedings of the National Academy of Sciences, 2003 Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is particularly common in neonates. Elevated bilirubin levels can be decreased by treatment with phenobarbital. Because the nuclear hormone receptor constitutive androstane receptor (CAR) mediates hepatic effects of this ...
Wendong, Huang +6 more
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The Environmental Estrogen, Nonylphenol, Activates the Constitutive Androstane Receptor [PDF]
Toxicological Sciences, 2007 Nonylphenol (NP) and its parent compounds, the nonylphenol ethoxylates are some of the most prevalent chemicals found in U.S. waterways. NP is also resistant to biodegradation and is a known environmental estrogen, which makes NP a chemical of concern.
Juan P, Hernandez +5 more
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A brief history of the discovery of PXR and CAR as xenobiotic receptors
Acta Pharmaceutica Sinica B, 2016 The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998.
Jiong Yan, Wen Xie
doaj +1 more source
PLoS ONE, 2012 Triclocarban (3,4,4'-trichlorocarbanilide, TCC) is used as a broad-based antimicrobial agent that is commonly added to personal hygiene products. Because of its extensive use in the health care industry and resistance to degradation in sewage treatment ...
Mei-Fei Yueh +4 more
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Alternatively spliced isoforms of the human constitutive androstane receptor [PDF]
Nucleic Acids Research, 2003 The nuclear receptor CAR (NR1I3) regulates transcription of genes encoding xenobiotic- and steroid-metabolizing enzymes. Regulatory processes that are mediated by CAR are modulated by a structurally diverse array of chemicals including common pharmaceutical and environmental agents.
Scott S, Auerbach +5 more
openaire +2 more sources
Dual action of oestrogens on the mouse constitutive androstane receptor [PDF]
Biochemical Journal, 2003 mCAR (mouse constitutive androstane receptor; NR1I3) controls the expression of cytochrome P450 as well as other enzymes involved in drug and steroid metabolism. The high basal activity of mCAR can be modulated by inhibitory steroids related to androstenol and by activating xenobiotic chemicals such as 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene and ...
Janne, Mäkinen +7 more
openaire +2 more sources