Results 51 to 60 of about 5,156 (193)

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research
Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan   +4 more
doaj   +1 more source

CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders

Cells, 2023
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting 70–90% of obese individuals. In humans, a lower NAFLD incidence is reported in pre-menopausal women, although the mechanisms affording this ...
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Véronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal   +8 more
doaj   +1 more source

Constitutive Androstane Receptor 1 is Constitutively Bound to Chromatin and 'Primed' for Transactivation in Hepatocytes [PDF]

Molecular Pharmacology, 2019
The constitutive androstane receptor (CAR) is a xenobiotic sensor expressed in hepatocytes that activates genes involved in drug metabolism, lipid homeostasis, and cell proliferation. Much progress has been made in understanding the mechanism of activation of human CAR by drugs and xenobiotics.
McMahon, Michael, Ding, Shaohong, Acosta-Jimenez, Lourdes, Terranova, Remi, Gerard, Marie-Apolline, Vitobello, Antonio, Moggs, Jonathan G., Henderson, Colin J., Wolf, C. Ronald   +8 more
openaire   +3 more sources

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

Sensors, 2015
The constitutive androstane receptor (CAR) is a critical nuclear receptor in the gene regulation of xenobiotic and endobiotic metabolism. The LanthaScreenTM TR-FRET CAR coactivator assay provides a simple and reliable method to analyze the affinity of a ...
Alejandro Carazo, Petr Pávek
doaj   +1 more source

Filling the blank space: Branched 4-nonylphenols isomers are responsible for robust constitutive androstane receptor (CAR) activation by nonylphenol

, 2023
4-Nonylphenol (4-NP), a para-substituted phenolic compound mixture comprising a straight or branched carbon chain, is a widespread ubiquitous environmental pollutant and food contaminant.
Thales, Kronenberger, Jan, Dusek, Albert, Braeuning, Kristin, Fritsche, Martin, Drastik, Azam, Rashidian, Petr, Pavek, Antti, Poso, Lucie, Smutná   +8 more
core   +1 more source

The Nuclear Receptor PXR in Chronic Liver Disease

Cells, 2021
Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P-glycoprotein, is functionally involved in chronic liver diseases of different ...
Katia Sayaf, Ilaria Zanotto, Francesco Paolo Russo, Daniela Gabbia, Sara De Martin   +4 more
doaj   +1 more source

Characterization of DNA Complexes Formed by the Nuclear Receptor Constitutive Androstane Receptor [PDF]

Journal of Biological Chemistry, 2003
The nuclear receptor constitutive androstane receptor (CAR) acts as a xenobiotic sensor and regulates the expression of enzymes, such as several cytochromes P450s and the UDP-glucuronosyltransferase (UGT) type 1A1. CAR binds as a heterodimer with the retinoid X receptor (RXR) to specific DNA sites, called response elements (REs).
Christian, Frank, Manuel Macias, Gonzalez, Carita, Oinonen, Thomas W, Dunlop, Carsten, Carlberg   +4 more
openaire   +2 more sources

Branched 4-nonylphenols isomers are responsible for robust constitutive androstane receptor (CAR) activation by nonylphenol

, 2023
<p>MD simulation data related to the publication Rashidian et al.: Branched 4-nonylphenols isomers are responsible for robust constitutive androstane receptor (CAR) activation by nonylphenol</p> <p> </p> <p>  ...
Rashidian Azam, Kronenberger Thales
core   +1 more source

Identification of Synthetic Urine by Analysis of Stable Carbon and Nitrogen Isotope Ratios and Comparison to Established GC‐MS/MS and LC‐MS/MS Analysis

Drug Testing and Analysis, EarlyView.
This study compared GC‐MS/MS, EA‐IRMS, and LC‐MS/MS for detecting synthetic and manipulated urine samples in doping control and forensic analysis. EA‐IRMS proved particularly effective for identifying mixtures of synthetic and authentic urine, providing a reliable complement to established authenticity testing methods.
Frank Hülsemann, Laura Franke, Dirk K. Wissenbach, Gregor Fußhöller, Mario Thevis   +4 more
wiley   +1 more source

Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans [PDF]

, 2001
Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP).
Stockli, J., Handschin, C., Meyer, U. A., Hoffmann, K., Podvinec, M.   +4 more
core