Results 61 to 70 of about 5,156 (193)

Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation. [PDF]

PLoS ONE, 2016
The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake ...
Marija Pinne, Elsa Ponce, Judy L Raucy
doaj   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Interaction of PER2 with the constitutive androstane receptor possibly links circadian rhythms to metabolism

Acta Chimica Slovenica, 2017
Period 2 (PER2) is an important factor in daily oscillations called circadian rhythms, which are emerging as one of the most important regulatory networks, responsible for homeostasis and transcriptional regulation of a number of genes.
Tomaž Martini, Jurij Stojan, Damjana Rozman, Uršula Prosenc Zmrzljak   +3 more
doaj   +1 more source

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

npj Systems Biology and Applications, 2021
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce.
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh   +12 more
doaj   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Nucleophosmin 1 induction is an early event in a Phenobarbital induced proliferation response in rat but not human liver 3D microtissues

Toxicology Reports
A key event in the process of rat but not human liver carcinogenesis caused by constitutive androstane receptor activators such as phenobarbital (PB) is hepatocyte proliferation, but the mechanism(s) underpinning this response is not fully understood ...
Matthew Elcombe, Stephanie Wallace, Simon Plummer   +2 more
doaj   +1 more source

Metformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation

Ожирение и метаболизм, 2014
Currently, metformin is a major hypoglycemic agents for the treatment of type 2 diabetes. The main antihyperglycemic effect of metformin - suppression of hepatic gluconeogenesis and glycolysis.

doaj   +1 more source

The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity

Cells, 2020
Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity.
Philip Marx-Stoelting, Constanze Knebel, Albert Braeuning   +2 more
doaj   +1 more source

Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2006
The CYP2C subfamily of cytochrome P450 monooxygenases is responsible for the metabolism of approximately 20% of therapeutic drugs and many endogenous compounds in humans. These enzymes can be induced by prior treatment with drugs, resulting in changes in drug efficacy.
Jonathan P, Jackson, Stephen S, Ferguson, Masahiko, Negishi, Joyce A, Goldstein   +3 more
openaire   +2 more sources

Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir, Astrid Kaiser, Felix F. Lillich, Pascal Heitel   +3 more
wiley   +1 more source