Results 61 to 70 of about 4,340 (154)

Saline Permafrost and Cryopegs as Potentially Important Sources of CO2—Assessing Organic Carbon Mineralization Potentials on the Alaskan Coastal Plain

Global Change Biology, Volume 32, Issue 7, July 2026.
Incubation experiments reveal that potentially carbon‐rich saline permafrost and cryopegs from Arctic coastal plains exhibit CO2 production potentials comparable to active layers. This could substantially shift greenhouse gas balances, as salinity is currently not accounted for in permafrost carbon assessments.
Fabian Seemann, Mackenzie R. Baysinger, Susanne Liebner, Claire Treat, Michael Zech, Maren Jenrich, Guido Grosse, Benjamin M. Jones, Jens Strauss   +8 more
wiley   +1 more source

Update of the risk assessment on emerging and novel brominated flame retardants in food

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to update its 2012 risk assessment on Emerging and Novel brominated flame retardants (BFRs) in food. Since the previous Opinion, further information was collected for a total of 27 BFRs. The CONTAM Panel concluded that TDBPP, DBPNG and TBNPA are considered genotoxic and carcinogenic.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Emilio Benfenati, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Edoardo Carnesecchi, Violetta Costanzo, Andrea Gissi, Eirini Kouloura, Luisa Ramos Bordajandi, Francesca Riolo, Christer Hogstrand   +33 more
wiley   +1 more source

Atypical functions of xenobiotic receptors in lipid and glucose metabolism

Medical Review, 2022
Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
doaj   +1 more source

Scientific Report on consumer health‐based guidance values for trifluoroacetic acid

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to provide a scientific report according to Article 31 of Regulation (EC) No 178/2002, in conjunction with Regulation (EC) No 1107/2009, to revise consumer health‐based guidance values, i.e. acceptable daily intake (ADI) and acute reference dose (ARfD), for trifluoroacetic acid (TFA). EFSA launched a targeted
EFSA (European Food Safety Authority), Adeline Cavelier, Tamara Coja, Andrea Gall, Antonio Hernández‐Jerez, Christiane Vleminckx, Elodie Bergsma, Marco Binaglia, Federica Crivellente, Mathilde Colas, Anna Lanzoni, Jochem Louisse, Rafaela Rodrigues De Jesus, Annetta Grillo, Iris Mangas, Juan Manuel Parra Morte   +15 more
wiley   +1 more source

Structure and Function of the Nuclear Receptor Constitutive Androstane Receptor

YAKUGAKU ZASSHI, 2016
Animal defense mechanisms against both endogenous and exogenous toxic compounds function mainly through receptor-type transcription factors, including the constitutive androstane receptor (CAR). Following xenobiotic stimulation, CAR translocates into the nucleus and transactivates its target genes including oxygenic and conjugative enzymes and ...
openaire   +3 more sources

Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2006
The CYP2C subfamily of cytochrome P450 monooxygenases is responsible for the metabolism of approximately 20% of therapeutic drugs and many endogenous compounds in humans. These enzymes can be induced by prior treatment with drugs, resulting in changes in drug efficacy.
Jonathan P, Jackson, Stephen S, Ferguson, Masahiko, Negishi, Joyce A, Goldstein   +3 more
openaire   +2 more sources

Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir, Astrid Kaiser, Felix F. Lillich, Pascal Heitel   +3 more
wiley   +1 more source

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, Volume 28, Issue 3, Page 855-867, June 2026.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Continuous Subcutaneous Ketamine Infusion May Induce Tacrolimus and Sirolimus Clearance: A Case Report

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 6, June 2026.
ABSTRACT Background Drug interactions involving immunosuppressants can compromise transplant outcomes. Although repeated ketamine administration induces hepatic enzymes in experimental models, clinical reports of induced clearance of cytochrome P450 (CYP) substrates are lacking. Continuous subcutaneous ketamine infusions are increasingly used for acute
Jana Stojanova, Bridin Murnion, Fay Burrows, Lilibeth Carlos, Tomoyuki Mizuno, Takanobu Nadai, Kei Irie, Nuala Helsby, Kavitha Muthiah, Richard Day   +9 more
wiley   +1 more source

Regulation of the human cathepsin E gene by the constitutive androstane receptor [PDF]

Archives of Biochemistry and Biophysics, 2007
Cathepsin E (CTSE) is an aspartic protease that has been linked to antigen processing and innate immunity. Elevated levels of CTSE expression have also been associated with several forms of cancer, including carcinomas exhibiting highly invasive character.
Jeanine L, Page, Stephen C, Strom, Curtis J, Omiecinski   +2 more
openaire   +2 more sources