Results 81 to 90 of about 4,340 (154)

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Scientific Reports, 2019
Bisphenol A (BPA) is used as an industrial raw material for polycarbonate plastics and epoxy resins; however, various concerns have been reported regarding its status as an endocrine-disrupting chemical.
Takahiro Masuya, Masaki Iwamoto, Xiaohui Liu, Ayami Matsushima   +3 more
doaj   +1 more source

The metabolic dysfunction-associated steatohepatitis (MASH) drug resmetirom exhibits broad nuclear receptor activity with minimal functional impact

Scientific Reports
In 2024, the FDA granted approval for resmetirom, a selective but moderately potent agonist of the thyroid hormone receptor (THR) β, marking the first drug for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) in the US.
Annette Kärcher, Laura Isigkeit, Nils Christiaan Bandomir, Manfred Schubert-Zsilavecz, Pascal Heitel   +4 more
doaj   +1 more source

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure. [PDF]

J Med Chem, 2023
Mejdrová I, Dušek J, Škach K, Stefela A, Skoda J, Chalupský K, Dohnalová K, Pavkova I, Kronenberger T, Rashidian A, Smutná L, Duchoslav V, Smutny T, Pávek P, Nencka R.   +14 more
europepmc   +1 more source

Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver. [PDF]

J Endocr Soc, 2022
Sen A, Goforth M, Cooper KK, Anakk S.
europepmc   +1 more source

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor. [PDF]

PLoS ONE, 2016
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel   +6 more
doaj   +1 more source

Induction of cytochrome P450 via upregulation of CAR and PXR: a potential mechanism for altered florfenicol metabolism by macranthoidin B in vivo

Frontiers in Pharmacology
IntroductionMacranthoidin B (MB) is a primary active component of Flos Lonicerae. In Chinese veterinary clinics, Flos Lonicerae is frequently used in combination with florfenicol to prevent and treat infections in livestock and poultry.
Si-cong Li, Si-cong Li, Bin Wang, Bin Wang, Min Zhang, Min Zhang, Qin Yin, Zi-yi Yang, Zi-yi Yang, Xu-ting Li, Xu-ting Li, Ge Liang, Ge Liang   +12 more
doaj   +1 more source

Constitutive Androstane Receptor Agonist, TCPOBOP: Maternal Exposure Impairs the Growth and Development of Female Offspring in Mice. [PDF]

Int J Mol Sci, 2023
Pan S, Guo Y, Yu W, Zhang J, Qiao X, Li L, Xu P, Zhai Y.   +7 more
europepmc   +1 more source

Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling. [PDF]

J Biol Chem, 2022
Li Z, Kwon SM, Li D, Li L, Peng X, Zhang J, Sueyoshi T, Raufman JP, Negishi M, Wang XW, Wang H.   +10 more
europepmc   +1 more source

Hibiscus sabdariffa Extract Protects HaCaT Cells against Phenanthrene-Induced Toxicity through the Regulation of Constitutive Androstane Receptor/Pregnane X Receptor Pathway. [PDF]

Nutrients, 2022
Malar DS, Prasanth MI, Verma K, Prasansuklab A, Tencomnao T.   +4 more
europepmc   +1 more source

Correction: MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor

PLoS ONE, 2013
Ryota Shizu, Sawako Shindo, Takemi Yoshida, Satoshi Numazawa   +3 more
doaj   +3 more sources