Results 101 to 110 of about 5,156 (193)

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science
Multiple prenatal adverse environmental factors alter hepatic cytochrome P450 (CYP) enzymes expression in offspring, with these changes persisting after birth.
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
doaj   +1 more source

An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device

, 2010
Bioartificial Liver Devices (BAL) could provide hepatic function in patients with liver failure awaiting transplantation or liver regeneration. Certain BALs use human hepatoblastoma-derived HepG2 cells that can perform many hepatocyte specific ...
Thomas, A.
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An identification of selective antagonists of constitutive androstane receptor [PDF]

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Karolína Ondraszková Supervisor: PharmDr. Tomáš Smutný, Ph.D.
Ondraszková, Karolína
core   +1 more source

The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems

, 2010
The constitutive androstane receptor (CAR) is a member of the nuclear receptor superfamily. The CAR is normally located in the cytoplasmic compartment of untreated liver cells and translocates to the nucleus after exposure to phenobarbital (PB) or PB ...
Inouye, Yoshio, Kanno, Yuichiro, Miyazaki, Yukari   +2 more
core   +1 more source

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes

Heliyon, 2019
In this study, we used reporter gene assays in COS-1 cells to examine the activation of rat pregnane X receptor (PXR), rat constitutive androstane receptor (CAR) and rat peroxisome-proliferator activated receptor (PPAR)α by pyrethroid pesticides, and to ...
Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Hiroyuki Nakajima, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura   +8 more
doaj   +1 more source

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Scientific Reports, 2019
Bisphenol A (BPA) is used as an industrial raw material for polycarbonate plastics and epoxy resins; however, various concerns have been reported regarding its status as an endocrine-disrupting chemical.
Takahiro Masuya, Masaki Iwamoto, Xiaohui Liu, Ayami Matsushima   +3 more
doaj   +1 more source

The metabolic dysfunction-associated steatohepatitis (MASH) drug resmetirom exhibits broad nuclear receptor activity with minimal functional impact

Scientific Reports
In 2024, the FDA granted approval for resmetirom, a selective but moderately potent agonist of the thyroid hormone receptor (THR) β, marking the first drug for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) in the US.
Annette Kärcher, Laura Isigkeit, Nils Christiaan Bandomir, Manfred Schubert-Zsilavecz, Pascal Heitel   +4 more
doaj   +1 more source

Efeito de ligantes dos receptores nucleares PXR e VDR na expressão de genes de biotransformação no fígado e intestino de peixes Danio rerio [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2010O receptor de Vitamina D (VDR) e o receptor Pregnano X (PXR) são receptores nucleares e agem como ...
Siebert, Marília Nardelli
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Molecular mechanisms of interactions- interactions of constitutive androstane receptor with selected stilbene compounds [PDF]

, 2019
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Lenka Linhartová Supervisor: Prof. PharmDr. Petr Pávek, Ph.D.
Linhartová, Lenka
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Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metab [PDF]

, 2006
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily. These transcription factors are predominantly expressed in the liver, where they are activated by structurally diverse compounds ...
Thomas K H Chang, David J Waxman
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