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The Constitutive Active/Androstane Receptor Regulates Phenytoin Induction of Cyp2c29
Molecular Pharmacology, 2004Many cytochrome P450 isoforms are known to be drug-inducible. The anticonvulsant phenytoin has been reported to be an inducer of human CYP2B6, CYP3A4, and murine CYP2C29. However, the molecular mechanism mediating phenytoin induction remains unclear.
Jonathan P, Jackson +4 more
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Constitutive Androstane Receptor Expression in the Rat Cervix During Gestation
Journal of the Society for Gynecologic Investigation, 2000To investigate expression of the constitutive androstane receptor (CAR) in the pregnant rat cervix.Rat uterine tissue was obtained on gestational days 12, 16, 20, 21, and 22 (the day of parturition), and postpartum day 1. In addition, liver, lung, kidney, heart, and skeletal muscle tissue were obtained.
D F, Rychlik, E, Bieber, M, Phillippe
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[Advances in the research of pregnane X receptor and constitutive androstane receptor].
Yao xue xue bao = Acta pharmaceutica Sinica, 2013Nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are originally characterized as transcription factors regulating many target genes. Recent works have revealed that these nuclear receptors play critical roles in regulating genes that encode drug metabolism enzymes and modulating hepatic energy metabolism, such as ...
Bing-fang, Hu, Hui-chang, Bi, Min, Huang
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Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation
Molecules, 2021Min-Tsang Hsieh +2 more
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