Results 111 to 120 of about 5,156 (193)

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

, 2018
The nuclear receptor constitutive androstane receptor (CAR; NR1I3) controls the inducible expression of many enzymes and transporters involved in drug metabolism and transport, energy metabolism and toxicity.
Honkakoski, Paavo, Prantner, Viktoria, Cinnamon, Yuval, Küblbeck, Jenni, Molnár, Ferdin   +4 more
core   +1 more source

Preparation of strategy for studying interaction of human constitutive androstane receptor with steroid receptor coactivator-1

, 2019
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy Candidate: Ivana Šachová Supervisors: PharmDr. Jan Martin, PhD., Dipl. Ing. Mgr. Ferdinand Molnár, PhD.
Šachová, Ivana
core  

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

, 2013
Phenobarbital is a central nervous system depressant that also indirectly activates nuclear receptor constitutive active androstane receptor (CAR), which promotes drug and energy metabolism, as well as cell growth (and death), in the liver. We found that
Sobhany, M., Moore, R., Pedersen, L., Sueyoshi, T., Negishi, M., Mutoh, S., Perera, L.   +6 more
core   +1 more source

Preparation of strategy for studying interaction of human constitutive androstane receptor with steroid receptor coactivator-1

, 2017
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy Candidate: Ivana Šachová Supervisors: PharmDr. Jan Martin, PhD., Dipl. Ing. Mgr. Ferdinand Molnár, PhD.
Šachová, Ivana
core  

Helix 11 Dynamics Is Critical for Constitutive Androstane Receptor Activity

, 2011
SummaryThe constitutive androstane receptor (CAR) transactivation can occur in the absence of exogenous ligand and this activity is enhanced by agonists TCPOBOP and meclizine.
Sarah Wisecarver, Patrick R. Griffin, Griffin, Patrick R., Busby, Scott A., Fernandez, Elias J., Jeremy Vincent, Edward Wright, Wright, Edward, Elias J. Fernandez, Scott A. Busby, Wisecarver, Sarah, Vincent, Jeremy   +11 more
core   +1 more source

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure. [PDF]

J Med Chem, 2023
Mejdrová I, Dušek J, Škach K, Stefela A, Skoda J, Chalupský K, Dohnalová K, Pavkova I, Kronenberger T, Rashidian A, Smutná L, Duchoslav V, Smutny T, Pávek P, Nencka R.   +14 more
europepmc   +1 more source

Ligand Specificity of Constitutive Androstane Receptor as Probed by Induced-Fit Docking and Mutagenesis

, 2016
Constitutive androstane receptor (CAR, NR1I3) belongs to the nuclear receptor family of transcription factors and acts as a chemical sensor of drugs and endogenous compounds.
Juha T. Pulkkinen (1656310), Paavo Honkakoski (2110219), Reino Laatikainen (1857733), Johanna Jyrkkärinne (2110222), Mark S. Johnson (166934), Susanna Repo (2406355)   +5 more
core   +1 more source

2‑(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists

, 2016
Constitutive androstane receptor (CAR) is a key regulator of xenobiotic and endobiotic metabolism. Together with pregnane X (PXR) and aryl hydrocarbon (AHR) receptors, it is referred to as “xenobiotic receptor”.
Tomas Smutny (2737300), Marcela Drechslerová (2737309), Alejandro Carazo (2737303), Alice Nova (2737294), Zuzana Rania Hrušková (2737297), Petr Pavek (2737291), Jiří Kuneš (1233537), Marcel Špulák (2328727), Lucie Hyrsova (2737306), Milan Pour (1676887)   +9 more
core   +1 more source

Identification of Novel Gut Microbiome Constitutive Androstane Receptor Ligands using an Untargeted Affinity Purification-Mass Spectrometry Approach

, 2022
The Constitutive Androstane Receptor (CAR) is a member of the Nuclear Receptor (NR) family of transcription factors and a key regulator of xenobiotic metabolism. Identification of high affinity CAR ligands has remained elusive.
Malekoltojari, Ainaz
core  

Induction of cytochrome P450 via upregulation of CAR and PXR: a potential mechanism for altered florfenicol metabolism by macranthoidin B in vivo

Frontiers in Pharmacology
IntroductionMacranthoidin B (MB) is a primary active component of Flos Lonicerae. In Chinese veterinary clinics, Flos Lonicerae is frequently used in combination with florfenicol to prevent and treat infections in livestock and poultry.
Si-cong Li, Si-cong Li, Bin Wang, Bin Wang, Min Zhang, Min Zhang, Qin Yin, Zi-yi Yang, Zi-yi Yang, Xu-ting Li, Xu-ting Li, Ge Liang, Ge Liang   +12 more
doaj   +1 more source