Results 91 to 100 of about 5,156 (193)
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen +5 more
wiley +1 more source
Testing of newly synthetized compounds with Constitutive androstane receptor (CAR) [PDF]
, 2012 Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Ioannis Mouratidis Supervisor: Doc. PharmDr. Petr Pávek Ph.D.
Mouratidis, Ioannis
core
Prioritising research on endocrine disruption in the marine environment: a global perspective
Biological Reviews, Volume 101, Issue 2, Page 848-868, April 2026.ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto +23 more
wiley +1 more source
, 2012 L'exposition à des contaminants environnementaux est suspectée de perturber les fonctions endocrino-métaboliques des organismes et contribuer au développement de pathologies métaboliques comme le diabète et la stéatose hépatique non alcoolique.
Marmugi, Alice
core
Molecular characterization of the A52 murine hepatocellular carcinoma cell line
Animal Models and Experimental Medicine, Volume 9, Issue 3, Page 546-557, March 2026.Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman +5 more
wiley +1 more source
Interactions of new compounds with constitutive androstane receptor [PDF]
, 2012 Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Jitka Lágnerová Supervisor: Doc. PharmDr. Petr Pávek, Ph.D.
Lágnerová, Jitka
core
, 2022 MD simulation data related to the publication Ivana Mejdrová et al.:Discovery of Human Constitutive androstane receptor (CAR) agonists with imidazo[1,2-a]pyridine structure Individual .zip files contain raw-desmond trajectories (trj.
Rashidian, Azam,Department of Internal Medicine VIII, University Hospital Tuebingen, Otfried-Müller-Strasse 14, Tuebingen DE 72076, Germany. +1 more
core +1 more source
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Coproporphyrin I (CPI) is increasingly recognized as a reliable endogenous biomarker for hepatic OATP1B transporters. However, confounding mechanisms such as increased heme biosynthesis driven by induction of CYP enzymes, which are hemoproteins, may affect CPI levels independently of OATP1B1 inhibition. The aim of this study was to investigate
Leila Potzel +5 more
wiley +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura +13 more
doaj +1 more source
, 2011 International audienceBackground and Aims: The constitutive androstane receptor (CAR) is known to be mainly involved in xenobiotic metabolism. The aim of our study was to assess whether pharmacological CAR activation could also affect cholesterol ...
T. Gautier +13 more
core +1 more source