Results 41 to 50 of about 4,340 (154)

Deciphering the roles of the constitutive androstane receptor in energy metabolism [PDF]

Acta Pharmacologica Sinica, 2014
The constitutive androstane receptor (CAR) is initially defined as a xenobiotic nuclear receptor that protects the liver from injury. Detoxification of damaging chemicals is achieved by CAR-mediated induction of drug-metabolizing enzymes and transporters.
Jiong, Yan, Baian, Chen, Jing, Lu, Wen, Xie   +3 more
openaire   +2 more sources

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research
Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan   +4 more
doaj   +1 more source

CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders

Cells, 2023
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting 70–90% of obese individuals. In humans, a lower NAFLD incidence is reported in pre-menopausal women, although the mechanisms affording this ...
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Véronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal   +8 more
doaj   +1 more source

Dietary Flavonoids Activate the Constitutive Androstane Receptor (CAR) [PDF]

Journal of Agricultural and Food Chemistry, 2010
The constitutive androstane receptor (CAR) is known as a xeno-sensor that regulates genes involved in xenobiotic excretion and energy metabolism. This study tested a variety of polyphenols for their ability to modulate CAR activity. HepG2 cells were transfected with a CAR expression plasmid and a reporter plasmid containing the human CYP2B6 regulatory ...
Ruiquing, Yao, Akihito, Yasuoka, Asuka, Kamei, Yoshinori, Kitagawa, Norifumi, Tateishi, Nobuo, Tsuruoka, Yoshionobu, Kiso, Tatsuya, Sueyoshi, Masahiko, Negishi, Takumi, Misaka, Keiko, Abe   +10 more
openaire   +2 more sources

Constitutive Androstane Receptor 1 is Constitutively Bound to Chromatin and 'Primed' for Transactivation in Hepatocytes [PDF]

Molecular Pharmacology, 2019
The constitutive androstane receptor (CAR) is a xenobiotic sensor expressed in hepatocytes that activates genes involved in drug metabolism, lipid homeostasis, and cell proliferation. Much progress has been made in understanding the mechanism of activation of human CAR by drugs and xenobiotics.
McMahon, Michael, Ding, Shaohong, Acosta-Jimenez, Lourdes, Terranova, Remi, Gerard, Marie-Apolline, Vitobello, Antonio, Moggs, Jonathan G., Henderson, Colin J., Wolf, C. Ronald   +8 more
openaire   +3 more sources

The Nuclear Receptor PXR in Chronic Liver Disease

Cells, 2021
Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P-glycoprotein, is functionally involved in chronic liver diseases of different ...
Katia Sayaf, Ilaria Zanotto, Francesco Paolo Russo, Daniela Gabbia, Sara De Martin   +4 more
doaj   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

Characterization of DNA Complexes Formed by the Nuclear Receptor Constitutive Androstane Receptor [PDF]

Journal of Biological Chemistry, 2003
The nuclear receptor constitutive androstane receptor (CAR) acts as a xenobiotic sensor and regulates the expression of enzymes, such as several cytochromes P450s and the UDP-glucuronosyltransferase (UGT) type 1A1. CAR binds as a heterodimer with the retinoid X receptor (RXR) to specific DNA sites, called response elements (REs).
Christian, Frank, Manuel Macias, Gonzalez, Carita, Oinonen, Thomas W, Dunlop, Carsten, Carlberg   +4 more
openaire   +2 more sources

Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation. [PDF]

PLoS ONE, 2016
The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake ...
Marija Pinne, Elsa Ponce, Judy L Raucy
doaj   +1 more source