Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L. [PDF]
Beilstein Journal of Organic Chemistry, 2019 Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity.
Annika Stein +4 more
doaj +6 more sources
Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes [PDF]
Frontiers in Molecular Neuroscience, 2020 The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds 1-9) to influence the functional activity of inhibitory glycine and γ-aminobutyric acid (GABA) receptors was estimated.
Julia V. Bukanova +2 more
doaj +4 more sources
Neurosteroid enantiomers as potentially novel neurotherapeutics. [PDF]
Neurosci Biobehav Rev, 2023 Endogenous neurosteroids and synthetic neuroactive steroids (NAS) are important targets for therapeutic development in neuropsychiatric disorders.
Covey DF +5 more
europepmc +3 more sources
Comprehensive Chemometric and Chromatographic Investigation of Lipophilicity of Biologically Active Androstane-3-Oxime Derivatives Across Diverse UHPLC Systems [PDF]
PharmaceuticalsBackground/Objectives: Previously reported analyses show that some androstane-3-oxime derivatives with picolyl and picolinylidene functional groups possess a significant anticancer activity towards various cancer cell lines.
Strahinja Z. Kovačević +4 more
doaj +2 more sources
Steroidogenic pathway in girls diagnosed with autism spectrum disorders. [PDF]
PLoS ONEThe diagnostic prevalence of autism spectrum disorders (ASD) shows boys to be more affected than girls. Due to this reason, there is a lack of research including and observing ASD girls.
Katarina Jansakova +8 more
doaj +2 more sources
Pseudomonas μtant strains that accumulate androstane and seco-androstane intermediates from bile acids [PDF]
Biochemical Journal, 1987 Transposon mutant strains which were affected in bile acid catabolism were isolated from four Pseudomonas spp. Two of the mutant groups isolated were found to accumulate 12 alpha-hydroxyandrosta-1,4-diene-3,17-dione as the major product from deoxycholic acid. Strains in one of these two groups were able to grow on steroids such as chenodeoxycholic acid,
R A, Leppik, D J, Sinden
openaire +4 more sources
New Insights into the Metabolism of Methyltestosterone and Metandienone: Detection of Novel A-Ring Reduced Metabolites. [PDF]
Molecules, 2021 Metandienone and methyltestosterone are orally active anabolic-androgenic steroids with a 17α-methyl structure that are prohibited in sports but are frequently detected in anti-doping analysis.
Loke S +10 more
europepmc +3 more sources
The analysis of chromatographic behavior of homoandrostane derivatives in reversed-phase ultra-high performance liquid chromatography [PDF]
Acta Periodica Technologica, 2021 Homoandrostane derivatives, as compounds with significant bioactivity, were studied in terms of their chromatographic behavior in reversed-phase ultra-high performance liquid chromatography (RP-UHPLC).
Kovačević Strahinja +9 more
doaj +1 more source
Reactivity of 17β-hydroxy-17α-substituted androstane derivatives [PDF]
Acta Periodica Technologica, 2010 The work concerns the reactivity of 17β-hydroxy-17α-substituted androstanes 1-9. Depending on the nature of the 17α-substituent, the presence of the neighboring 16-oximino group, and the reagent used, these compounds can undergo retroaddition (10-12 ...
Penov-Gaši Katarina M. +6 more
doaj +1 more source
Computational modeling of distribution coefficients and their correlations with pharmacokinetic properties of 17α-picolyl and 17(E)-picolinylidene androstane derivatives [PDF]
Acta Periodica Technologica, 2019 The present study describes the computational modeling of distribution coefficient (logD) of 17α-picolyl and 17(E)-picolinylidene androstane derivatives, as a group of compounds with significant anticancer activities.
Kovačević Strahinja Z. +3 more
doaj +1 more source