Results 11 to 20 of about 7,631 (266)

ChemInform Abstract: The Epoxidation of Androstane and Pregnane 2,4‐Dienes. [PDF]

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
James R. Hansons, Ismail Kiran
openaire   +4 more sources

Steroids of pregnant mare's urine. 5. Identification of two androstane-3:16-diols. The structure of ‘uranolone’ [PDF]

, 1957
R. V. Brooks, W. Klyne
core   +3 more sources

Reactivity of 17β-hydroxy-17α-substituted androstane derivatives [PDF]

Acta Periodica Technologica, 2010
The work concerns the reactivity of 17β-hydroxy-17α-substituted androstanes 1-9. Depending on the nature of the 17α-substituent, the presence of the neighboring 16-oximino group, and the reagent used, these compounds can undergo retroaddition (10-12 ...
Penov-Gaši Katarina M., Gaković Andrea R., Ajduković Jovana J., Đurendić-Brenesel Maja Đ., Đurendić Evgenija A., Savić Marina P., Sakač Marija N.   +6 more
doaj   +1 more source

Computational modeling of distribution coefficients and their correlations with pharmacokinetic properties of 17α-picolyl and 17(E)-picolinylidene androstane derivatives [PDF]

Acta Periodica Technologica, 2019
The present study describes the computational modeling of distribution coefficient (logD) of 17α-picolyl and 17(E)-picolinylidene androstane derivatives, as a group of compounds with significant anticancer activities.
Kovačević Strahinja Z., Karadžić-Banjac Milica Ž., Podunavac-Kuzmanović Sanja O., Ajduković Jovana J.   +3 more
doaj   +1 more source

Clinical Relevance of the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2022
Constitutive androstane receptor (CAR) (NR1I3), a xenobiotic receptor, has long been considered a master mediator of drug disposition and detoxification. Accumulating evidence indicates that CAR also participates in various physiologic and pathophysiological pathways regulating the homeostasis of glucose, lipid, and bile acids, and contributing to cell
Sydney, Stern, Ritika, Kurian, Hongbing, Wang   +2 more
openaire   +2 more sources

Activation of the Constitutive Androstane Receptor by Monophthalates [PDF]

Chemical Research in Toxicology, 2016
Humans in industrialized areas are continuously exposed to phthalate plasticizers, prompting concerns of their potential toxicities. Previous studies from our laboratory and others have shown that various phthalates activate several mammalian nuclear receptors, in particular the constitutive androstane receptor (CAR), the pregnane X receptor (PXR), and
Denise M. Coslo, Elizabeth M. Laurenzana, Anthony M. Roman, Curtis J. Omiecinski, M. Veronica Vigilar   +4 more
openaire   +3 more sources

Investigations on Phase I Metabolism of Anabolic Androgenic Steroids and Its Influenceability as Tool to Refine Steroid Detection and Evaluation [PDF]

, 2021
This thesis addresses the steroid metabolism and its role in the detection of steroids. The results were achieved by performing metabolic studies in combination with different analytical techniques. Three main outcomes were achieved.
Stoll, Anna
core   +1 more source

Hemisynthesis of 2,3,4-13C3-1,4-Androstadien-3,17-dione: A Key Precursor for the Synthesis of 13C3-Androstanes and 13C3-Estranes.

Journal of Organic Chemistry, 2018
In this contribution, we describe two simple and efficient routes for the preparation of keto-aldehyde 1, a key intermediate for the synthesis of 13C3-androstanes and 13C3-estranes.
Clément Berthonneau, Pierrick Nun, M. Rivière, M. Pauvert, F. Dénès, J. Lebreton   +5 more
semanticscholar   +1 more source

Redetermination of 5α-androstane-3,17-dione [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The structure of the title compound, C(19)H(28)O(2), has been redermined at 295 (2) K, with much improved precision. The structure and mol-ecular packing of the title compound was first reported by Coiro et al. [Acta Cryst. (1973). B29, 1404-1409] by means of potential-energy calculations.
Jasinski, Jerry P., Butcher, Ray J., Hakim Al-arique, Q. N. M., Yathirajan, H. S., Narayana, B.   +4 more
openaire   +4 more sources

Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR [PDF]

, 2009
Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn is activated by structurally diverse agonists including steroid hormones.
A Bender, A Biswas, A Khandelwal, AE Klon, AK Dunker, AK Ghose, B Blumberg, BL Urquhart, CR Yates, CY Ung, D Gupta, D Rogers, D Schuster, DG Teotico, DG Teotico, Erica J. Reschly, G Bertilsson, G Jones, IV Tetko, IV Tetko, J Feng, J Zhou, James M. Briggs, JE Chrencik, JT Metz, K Azzaoui, K Bachmann, K Yasuda, M Hassan, M Suarez, MA Lill, MA Lill, MA Lill, Manisha Iyer, Markus A. Lill, Matthew D. Krasowski, Matthew R. Redinbo, MD Krasowski, MD Krasowski, MN Jacobs, Nidhi, P Prathipati, RD Cramer, RE Watkins, RE Watkins, RE Watkins, S Ekins, S Ekins, S Ekins, S Ekins, S Ekins, S Ekins, S Kortagere, S Kortagere, S Kortagere, S Mani, S Verma, SA Kliewer, Sandhya Kortagere, Sean Ekins, W Mnif, WL DeLano, Y Xue, Y Xue, YD Gao   +64 more
core   +6 more sources