Results 211 to 220 of about 7,631 (266)

Metabolism of 5α-androstane-3β,17β-diol to 17β-hydroxy-5α-androstan-3-one and 5α-androstan-3α,17β-diol in the rat

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
Significant metabolism of 5 alpha-androstane-3 beta,17 beta-diol to 17 beta-hydroxy-5 alpha-androstan-3-one was recorded in several tissues and organs from rats and humans. This bioconversion was further investigated in rat testis homogenates. 5 alpha-Androstane-3 beta,17 beta-diol was readily metabolized to 17 beta-hydroxy-5 alpha-androstan-3-one with
Kristen B. Eik-Nes, Per A. Rosness, Arne Sunde   +2 more
openaire   +2 more sources

Cytotoxic androstane derivatives from Sarcococca ruscifolia

Fitoterapia, 2020
Sarcorusones A-D (1-4), four new androstane (C19-steroid) derivatives were characterized from Sarcococca ruscifolia along with five known compounds. Their structures were elucidated on the basis of extensive MS and NMR spectroscopic analysis. All the new structures share common 14-hydroxyl and 17-ketone functional groups, and compounds 2-4 feature a ...
Xiao-Dong Luo, Xiao-Dong Luo, Xin Yi, Xing-Wei Yang, Ya-Ping Liu, Tian-Zhen Xie, Li-Xing Zhao, Xia Xiao, Zhi Dai   +8 more
openaire   +3 more sources

Microbiological hydroxylation. Part XVIII. Introduction of 16α-, 9α-, and 3α-hydroxy-groups into dioxygenated 5α-androstanes by the fungus Diaporthe celastrina

, 1975
Diaporthe celastrina, a fungus not previously reported as being active with steroids, hydroxylates a range of dioxygenated 5α-androstanes generally by attack on the α-face.
A. M. Bell, A. D. Boul, E. Jones, G. Meakins, J. Miners, A. Wilkins   +5 more
semanticscholar   +1 more source

Microbiological hydroxylation. Part XX. Hydroxylation of dioxygenated 5alpha-androstanes with the fungi Absidia regnieri and Syncephelastrum racemosum.

Journal of The Chemical Society-perkin Transactions 1, 1975
Dioxygenated androstanes are readily hydroxylated by the title fungi. Although complex mixtures are generally formed, 3β-hydroxy-5α-androstan-7-one is converted efficiently into its 12α-hydroxy-derivative (51% yield) by S. racemosum.
A. M. Bell, E. Jones, G. Meakins, J. Miners, A. Wilkins   +4 more
semanticscholar   +1 more source

Studies in the steroid group. LXXXIV. Preparation and reactions of 15-oxygenated androstanes.

Journal of The Chemical Society-perkin Transactions 1, 1972
Treatment of 15β, 16β-epoxy-5α-androstan-17-one with hydrazine and toluene-p-sulphonic acid in air gives 5α-androstan-15β-ol; this step markedly improves the chemical route to 5α-androstan-15-one from the 3-ketone.
I. M. Clark, W. Denny, E. Jones, G. Meakins, A. Pendlebury, J. Pinhey   +5 more
semanticscholar   +1 more source

Microbiological hydroxylation of steroids. Part XI. Convenient routes to 3,7-, 3,11-, 3,12-, 7,11-, 7,17-, and 11,17-dioxygenated 5α-androstanes and to 5α-androstan-11-one

, 1974
Suitable, readily available 3,17-dioxygenated 5α-androstanes are hydroxylated efficiently at position 11 by Aspergillus ochraceus and at position 7 by Rhizopus nigricans.
A. M. Bell, V. Chambers, Sean Ewart, Richard H. Jones, G. Meakins, W. E. Müller, J. Pragnell   +6 more
semanticscholar   +1 more source

5β-Androstan-3,17-dione

Acta Crystallographica Section C Crystal Structure Communications, 1998
The title compound, C 19 H 28 O 2 , has the 5β configuration and a bowing angle of 71.76 (5) ° at the A/B ring junction. The crystal structure is stabilized by weak intermolecular C-H…O and van der Waals interactions.
Addlagatta Anthony, Ashwini Nangia, Mariusz Jaskolski, Gautam R. Desiraju   +3 more
openaire   +2 more sources

Syntheses of 17β-(2-maleimido)androstanes [PDF]

Collection of Czechoslovak Chemical Communications, 1981
Starting from pregnane derivatives, 17β-(2-maleimido)androstanes of 5α- and Δ5-series, with and without a 3β-acetoxy group, were prepared via methyl 3-androstanyl-3-cyano acrylates. The maleimidoandrostanes were synthesized as models of cardiotonic steroids.
Miroslav Havel, Pavel Drašar
openaire   +1 more source

EFFECTS OF ANDROSTENES, 5α-ANDROSTANES, 5β-ANDROSTANES, OESTRENES AND OESTRATRIENES ON SERUM GONADOTROPHIN LEVELS AND VENTRAL PROSTATE WEIGHTS IN GONADECTOMIZED, ADULT MALE RATS

, 1976
: The morphologic and metabolic effect of a single intracutaneous injection of homologous endocrine pancreas in Freund's complete adjuvant (CFA) was studied in 100 mice and compared with control groups which had been (1) immunized with murine insulin in ...
H. Verjans, K. Eik‐Nes
semanticscholar   +1 more source

Microbiological hydroxylation of steroids. VI. Hydroxylation of simple mono- and di-oxygenated 5 -androstanes and of 3-oxoestranes with the fungus Aspergillus ochraceus.

Journal of The Chemical Society-perkin Transactions 1, 1972
Of the eleven 5α-androstane monoketones, only two are hydroxylated by Aspergillus ochraceus. 5α-Androstan-3-one (and 5α-estran-3-one and the related Δ4-3-ketones) give 11α-hydroxy- and then 6β,11α-dihydroxy-compounds; 5α-androstan-17-one gives a 7β,11α ...
A. M. Bell, J. W. Browne, W. Denny, E. Jones, J. A. Kasal, G. Meakins   +5 more
semanticscholar   +1 more source