A Click Approach to Novel D-Ring-Substituted 16α-Triazolylestrone Derivatives and Characterization of Their Antiproliferative Properties [PDF]
, 2015 A simple and efficient synthesis of novel, D-ring substituted estrone derivatives containing a 16α-triazolyl moiety is described. Two epimeric azido alcohols (16α-azido-17α-hydroxy and 16α-azido-17β-hydroxy) of estra-1,3,5(10)-triene-3-methyl ether were ...
Kádár, Zalán +7 more
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Searching for Constitutive Androstane Receptor Modulators [PDF]
Drug Metabolism and Disposition, 2022 The constitutive androstane receptor (CAR; NR1I3) has been established as one of the main drug- and xenobiotic-responsive transcriptional regulators, collectively called xenosensors. CAR activates the expression of several oxidative, hydrolytic, and conjugative drug-metabolizing enzymes and drug transporters, and therefore, it contributes to drug and ...
openaire +2 more sources
Regulation of 3β-Hydroxysteroid Dehydrogenase/∆5-∆4 Isomerase: A Review [PDF]
, 2013 This review focuses on the expression and regulation of 3β-hydroxysteroi ddehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids ...
Abbaszade +121 more
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13C-NMR and mass spectral data of steroids with a 17,17-dialkyl-18-nor-13(14)-ene substructure
Journal of Lipid Research, 1997 We present carbon-13 nuclear magnetic resonance (13C-NMR) and mass spectral data for several androstanes and estranes having a 17,17-dialkyl-18-nor-13(14)-ene substructure. These compounds are formed by a Wagner-Meerwein rearrangement of steroids bearing
V I De Brabandere +3 more
doaj +1 more source
Evaluation of A-ring fused pyridine d-modified androstane derivatives for antiproliferative and aldo-keto reductase 1C3 inhibitory activity. [PDF]
Medchemcomm, 2018 Savić MP +8 more
europepmc +3 more sources
Redetermination of 5α-androstane-3,17-dione [PDF]
Acta Crystallographica Section E Structure Reports Online, 2010 The structure of the title compound, C(19)H(28)O(2), has been redermined at 295 (2) K, with much improved precision. The structure and mol-ecular packing of the title compound was first reported by Coiro et al. [Acta Cryst. (1973). B29, 1404-1409] by means of potential-energy calculations.
Jasinski, Jerry P. +4 more
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Synthesis and biochemical studies of 17-substituted androst-3-enes and 3,4-epoxyandrostanes as aromatase inhibitors [PDF]
, 2008 http://www.sciencedirect.com/science/article/B6TC9-4T0WJXG-2/2 ...
Banting +26 more
core +1 more source
Quantification of a glucocorticoid profile in non-pooled samples is pivotal in stress research across vertebrates [PDF]
, 2018 Vertebrates are faced continuously with a variety of potential stressful stimuli and react by a highly conserved endocrine stress response. An immediate catecholamine mediated response increases plasma glucose levels in order to prepare the organism for ...
Aerts, Johan
core +2 more sources
Journal of Lipid Research, 2017 Members of the gastrointestinal microbiota are known to convert glucocorticoids to androstanes, which are subsequently converted to potent androgens by other members of the gut microbiota or host tissues.
Saravanan Devendran +2 more
doaj +1 more source
Arylmethylamino steroids as antiparasitic agents [PDF]
, 2017 In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive ...
Becker, Katja +19 more
core +3 more sources