Discovery of ferroelectricity in natural product androstane
Discover Materials, 2023 AbstractProgesterone and its derivatives attracted widespread interest because of their applications in medicine, health care and birth control, which is the main active ingredient of contraceptive pills known as one of the five chemistry discoveries that changed human life. Although the research of pharmacological effects on contraceptive pill-related
Ren-Gen Xiong +2 more
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Nontargeted evaluation of the fate of steroids during wastewater treatment by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry [PDF]
, 2016 Emerging organic contaminants in wastewater are usually analyzed by targeted approaches, and especially estrogens have been the focus of environmental research due to their high hormonal activity. The selection of specific target compounds means, however,
Kopperi, Matias +3 more
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Circulating steroid levels as correlates of adipose tissue phenotype in premenopausal women [PDF]
, 2018 Background: Obesity-related alterations in the circulating steroid hormone profile remain equivocal in women. Our objective was to identify circulating steroid levels that relate to increased adiposity and altered adipose phenotype in premenopausal ...
Adamski, Jerzy +8 more
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Pseudomonas μtant strains that accumulate androstane and seco-androstane intermediates from bile acids [PDF]
Biochemical Journal, 1987 Transposon mutant strains which were affected in bile acid catabolism were isolated from four Pseudomonas spp. Two of the mutant groups isolated were found to accumulate 12 alpha-hydroxyandrosta-1,4-diene-3,17-dione as the major product from deoxycholic acid. Strains in one of these two groups were able to grow on steroids such as chenodeoxycholic acid,
R A Leppik, D J Sinden
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Regulation of 3β-Hydroxysteroid Dehydrogenase/∆5-∆4 Isomerase: A Review [PDF]
, 2013 This review focuses on the expression and regulation of 3β-hydroxysteroi ddehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids ...
Abbaszade +121 more
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The Preparation of Some 13α-Androstanes
Collection of Czechoslovak Chemical Communications, 1998 The preparation of 17a-oxa-5α,13α-androstane-3,17-dione, 5α,13α-androstane-3,7,17-trione, 4-chloro- and 4-hydroxy-13α-androst-4-ene-3,17-dione and 13α-androst-4-ene-3,6,17-trione is described.
James R Hanson +2 more
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Microbial Cell Factories, 2018 Background Metabolic activities of microorganisms to modify the chemical structures of organic compounds became an effective tool for the production of high-valued steroidal drugs or their precursors.
Alina Świzdor +2 more
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Searching for Constitutive Androstane Receptor Modulators [PDF]
Drug Metabolism and Disposition, 2022 The constitutive androstane receptor (CAR; NR1I3) has been established as one of the main drug- and xenobiotic-responsive transcriptional regulators, collectively called xenosensors. CAR activates the expression of several oxidative, hydrolytic, and conjugative drug-metabolizing enzymes and drug transporters, and therefore, it contributes to drug and ...
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Multiselective Diels–Alder Reaction of α-Arylacroleins Catalyzed by Boron Tribromide-Assisted Chiral Phosphoric Acids [PDF]
, 2022 A multiselective Diels–Alder (DA) reaction of α-arylacroleins with cyclopentadiene using BBr3-assisted chiral BINOL-derived phosphoric acid catalysts has been developed.
Hatano, Manabu +3 more
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Olfactory sensitivity to steroid glucuronates in Mozambique tilapia suggests two distinct and specific receptors for pheromone detection [PDF]
, 2014 Cichlids offer an exciting opportunity to understand vertebrate speciation; chemical communication could be one of the drivers of African cichlid radiation.
Canario, Adelino V. M. +2 more
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