Results 51 to 60 of about 7,631 (266)
13C-NMR and mass spectral data of steroids with a 17,17-dialkyl-18-nor-13(14)-ene substructure
Journal of Lipid Research, 1997 We present carbon-13 nuclear magnetic resonance (13C-NMR) and mass spectral data for several androstanes and estranes having a 17,17-dialkyl-18-nor-13(14)-ene substructure. These compounds are formed by a Wagner-Meerwein rearrangement of steroids bearing
V I De Brabandere +3 more
doaj
ChemMedChem, Volume 20, Issue 8, April 14, 2025.Analogs of the aminosteroid SHIP inhibitor 3α‐aminocholestane (3AC) have been synthesized and tested. Deletion of the C17 alkyl chain improves water solubility, however these analogs inhibit both SHIP1 and SHIP2. Enzyme kinetics imply that these aminosteroids are competitive inhibitors, and a model of the inhibitors within the active site of SHIP is ...
Angela M. Pacherille +13 more
wiley +1 more source
Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain [PDF]
, 2005 Steroids in the brain arise both from local synthesis and from peripheral sources and have a variety of effects on neuronal function. However, there is little direct chemical evidence for the range of steroids present in brain or of the pathways for ...
Corol, DI +4 more
core +1 more source
The Role of Cholesterol Metabolism and Its Regulation in Tumor Development
Cancer Medicine, Volume 14, Issue 7, April 2025.ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu +5 more
wiley +1 more source
Journal of Lipid Research, 2017 Members of the gastrointestinal microbiota are known to convert glucocorticoids to androstanes, which are subsequently converted to potent androgens by other members of the gut microbiota or host tissues.
Saravanan Devendran +2 more
doaj
A physico-chemical study of some areas of fundamental significance to biophysics [PDF]
, 1992 This report discusses the following topics on Biophysics: Radiation signatures; electronic structure of steroids and vitamins; laser optogalvanic effect; vacuum ultraviolet spectroscopy; and ...
Kumar, Devendra, McGlynn, S. P.
core +2 more sources
Drug Development Research, Volume 86, Issue 2, April 2025.ABSTRACT Studies suggest that vegetarians and Asians have lower mortality rates from prostate cancer compared to men who follow a Western diet. β‐sitosterol, a key compound of plant‐based diets, has been found to induce significant changes in the ultrasonic structure of the prostatic adenomas, making it a promising candidate for further prostate cancer
Marisa Cabeza +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 12, March 27, 2025.The authors uncovered that targeting the constitutive androstane receptor (CAR) might decelerate the aging process. Employing models like C. elegans and mice, they determined that CAR agonists CITCO and TCPOBOP can extend both the lifespan and healthspan.
Jing Yu +12 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 3, March 2025.Elatostema sessile exhibits remarkable antioxidant properties, effectively scavenging free radicals and reducing oxidative stress, crucial in preventing various diseases. Additionally, its cytotoxic potential suggests promising anticancer applications, while its analgesic effects help in pain management by modulating nociceptive pathways.
Aninda Kumar Nath +8 more
wiley +1 more source
The Branched GDGT Isomer Ratio Refines Lacustrine Paleotemperature Estimates
Geochemistry, Geophysics, Geosystems, Volume 26, Issue 3, March 2025.Abstract Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are membrane‐spanning lipids synthesized by bacteria in numerous substrates. The degree of methylation of the five methyl brGDGTs in both soils and lake sediments, described by the MBT′5Me index, is empirically related to surface atmospheric temperature.
Joseph B. Novak +7 more
wiley +1 more source