Results 51 to 60 of about 2,751 (216)

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

Recent developments in the use of isotope ratio mass spectrometry in sports drug testing [PDF]

, 2018
According to the annual report of the World Anti-Doping Agency, steroids are the most frequently detected class of doping agents. Detecting the misuse of endogenously occurring steroids, i.e.
Emery, Caroline, Piper, Thomas, Saugy, Martial   +2 more
core  

The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith, Danielle Graden, Lauren L. R. Lohmer, Joy Schleyer, Stephen P. Wanaski   +4 more
wiley   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Updated peer review of the pesticide risk assessment of the active substance pydiflumetofen

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France and co‐rapporteur Member State Austria for the pesticide active substance pydiflumetofen and the assessment of applications for maximum residue ...
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, Varvara Gouliarmou, Katrin Halling, Laia Herrero Nogareda, Alessio Ippolito, Frederique Istace, Samira Jarrah, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Anamarija Romac, Agnès Rortais, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Andrea Terron, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +50 more
wiley   +1 more source

Detection of Anabolic Androgenic Steroids and Steroid Esters—Comparing Dried Blood Spots Collection Devices and Urine Samples

Drug Testing and Analysis, Volume 17, Issue 12, Page 2374-2383, December 2025.
DBS (Capitainer‐B50 and Tasso‐M20) enabled detection of testosterone esters in all participants, whereas urine testing (T/E) missed cases including potential UGT2B17 del/del carriers and individuals with testosterone prescription. More AAS and steroid‐esters could be detected in Capitainer‐B50 versus Tasso‐M20.
Tina Suominen, Jeanette von Walden, Laura Harju, Anton Pohanka, Jenny Schulze, Mikael Lehtihet, Lena Ekström   +6 more
wiley   +1 more source

Overcoming the Challenge of Confident Identification Among Two Related Groups of 17‐Methyl Steroids by GC–MS

Journal of Separation Science, Volume 48, Issue 12, December 2025.
ABSTRACT Tetrahydromethyltestosterone (THMT) and 20‐hydroxymethyl‐18‐nortetrahydromethyltestosterone (20OHnorTHMT) are metabolites of the anabolic androgenic steroids methyltestosterone and metandienone. Both molecular structures are used as markers in anti‐doping analysis. There are eight reasonable diastereomeric structures of each group relevant for
Jakob Steff, Xavier de la Torre, Francesco Botrè, Maria Kristina Parr   +3 more
wiley   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 2095-2106, December 2025.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins, Blessed W. Aruldhas, Ingrid F. Metzger, Jessica B. L. Lu, Michael A. Heathman, Sara K. Quinney, Zeruesenay Desta   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Nuclear hormone receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S242-S258, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, John A. Cidlowski, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laurel Coons, Peter J. Fuller, Kenneth S. Korach, Donald P. McDonell, Robert Oakley, Sarah Radi, Rachid Safi, Frances Sladek, Morag J. Young   +20 more
wiley   +1 more source

The assessment for potential thyroid‐mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract Amphibians (specifically Xenopus laevis) are used as the model species to assess potential endocrine‐disrupting properties in non‐mammalian species through thyroid modality. The amphibian metamorphosis assay is the most frequently available test.
European Food Safety Authority (EFSA), Lisa Baumann, Alice Baynes, Susanne Hougaard Bennekou, Kevin Crofton, Zhichao Dang, Sigmund Degitz, Jean‐Baptiste Fini, Mary Gilbert, Henrik Holbech, Andrea Terron, Majorie Van Duursen, Emily McVey, Maria Arena, Aude Kienzler, Simone Rizzuto, Laura Villamar Bouza, Martin Wilks   +17 more
wiley   +1 more source