Results 181 to 190 of about 1,570 (204)

Stimulation of Human Hematopoiesis: The Androstene Link.

Blood, 2006
Abstract 5-Androstene-3β, 17β-diol (AED) is a naturally occurring member of the androstene series of steroids. In models of chemotherapy and radiation-induced mylosuppression, AED expanded hematopoietic stem and progenitor cells (HSPC), decreased need for clinical support and increased survival.
James Frincke, Charles Dowding, Christopher Reading, Armando Garsd, Ajay Malik, Dwight R. Stickney, Jessie R. Groothuis   +6 more
openaire   +1 more source

The metabolism of 16-androstenes in boar salivary glands

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
Abstract The metabolism of 5α-[5α- 3 H]androst-16-en-3-one and [7α- 3 H]androsta-4, 16-dien-3-one by minces of boar submaxillary and parotid glands has been studied. Both ketones were reduced to mixtures of 5α-androst-16-en-3α- and -3β-ols by submaxillary gland tissue and to the 3α-alcohol by parotid gland tissue.
T, Katkov, W D, Booth, D B, Gower
openaire   +2 more sources

Structure–Activity Relationships in 16- and 17-Substituted 5-Androstenes: 3β-Acetoxy-17β-picolyl-5-androsten-16-one

Acta Crystallographica Section C Crystal Structure Communications, 1998
The title compound, 3β-acetoxy-17β-picolyl-5-androsten-16-one, C 27 H 35 NO 3 , was synthesized from a mixture of Z and E isomers of 3β-acetoxy-17-picolinylidene-5-androsten-16-one. The significant difference in these three compounds in the crystalline state lies in the conformation of the five-membered D ring, as well as in the orientation of the ...
D. Lazar, S. Stankovic, M. Sakac, K. Penov-Gasic, R. Kovacevic, L. Medic-Mijacevic, T. Pilati   +6 more
openaire   +1 more source

Structure–activity relationships in 4- and 5-androstene: 3β-acetoxy-17-methyl-17-oxo-16,17-seco-5-androstene-16-carbonitrile and 17-methyl-3,17-dioxo-16,17-seco-4-androstene-16-carbonitrile

Acta Crystallographica Section C Crystal Structure Communications, 2004
The title compounds, C22H31NO3 and C20H27NO2, have similar conformations except in the molecular geometry and the bonding of two of the rings. These differences lead to marked differences in the biological activities of these compounds. Molecules of both compounds are linked by weak C-H...O hydrogen bonds in the crystal structures.
Dusan, Lazar, Olivera, Klisurić, Slobodanka, Stanković, Katarina, Penov-Gasi, Evgenija, Djurendić, Radmila, Kovacević   +5 more
openaire   +2 more sources

Hydroformylation – amidocarbonylation of androstene and pregnene derivatives

Applied Organometallic Chemistry, 2002
AbstractAndrostene and pregnene derivatives were functionalized by amides with rhodium or binary rhodium–cobalt catalysts. Whereas the Rh–PPh3 catalyzed reaction results in the unsaturated amido‐methylidene derivatives, the rapid hydrogenation of these compounds takes place in the presence of a basic PR3 ligand.
Emese Nagy, Csilla Benedek, Bálint Heil, Szilárd Tőrös   +3 more
openaire   +1 more source

The metabolism in man of (3H)-5alpha-16-androsten-3alpha-ol and of (3H)-5alpha-16-androsten-3-one.

Hormone research, 1978
The in vitro metabolism in man of two 16-androstene steroids, 5alpha-16-androsten-3-one and 5alpha-16-androsten-3alpha-ol, has been studied using 3H-labelled tracers. 4 healthy subjects (2 of each sex) were chosen, and each labelled steroid was administered, by a single injection, to 1 man and 1 woman.
A E, Kingsbury, B W, Brooksbank
openaire   +2 more sources

ChemInform Abstract: Structure—Activity Relationships in 16‐ and 17‐Substituted 5‐Androstenes: 3β‐Acetoxy‐17β‐picolyl‐5‐androsten‐16‐one.

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dusan Lazar, Slobodanka Stankovic, Marija Sakac, Katarina Penov‐Gasic, Radmila Kovacevic, Ljubica Medic‐Mijacevic, Tullio Pilati   +6 more
openaire   +1 more source

Immune up-regulation and tumor apoptosis by androstene steroids

Steroids, 2002
beta Androstenes steroid up-regulates immunity to increase resistance against lethal infection and lethal radiation, and mediates a rapid recovery of hematopoietic precursor cells after radiation injury. beta Androstenetriol increases the levels of the TH(1) cytokines, IL-2, IL-3, IFN gamma and counteracts hydrocortisone mediated immune suppression. In
openaire   +2 more sources

Isomerization of 5-androsten-3,17-dione by hepatic tissue

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
Abstract The properties of the system in the soluble fraction of rat liver which catalyzes the conversion of 5-androsten-3,17-dione to the corresponding Δ 4 -3-ketone have been studied. Two components are required: a protein and a dialyzable organic molecule.
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Beta-Androstenes and Resistance to Viral and Bacterial Infections

Neuroimmunomodulation, 2009
This report illustrates that the β-androstenes are indeed able to upregulate the host immune response to a level that enables the host to resist lethal infection by viruses or bacteria. These agents consist of a subgroup of steroids, which also mediates a rapid recovery of hematopoietic precursor cells after whole-body lethal radiation injury. In vivo,
openaire   +2 more sources