Results 1 to 10 of about 33,998 (196)

Relationship of body composition with cortisol and dehydroepiandrosterone sulfate levels in Korean men and women [PDF]

Journal of International Medical Research
Background Glucocorticoids, primarily cortisol, mediated by the hypothalamic–pituitary–adrenal axis, significantly influence metabolic responses, including insulin resistance, lipolysis, and body fat distribution.
Sat Byul Park
doaj   +2 more sources

The metabolism of dehydroepiandrosterone sulfate and dehydroepiandrosterone

The Aging Male, 1998
Dehydroepiandrosterone sulfate (DHEAS), one of the major secretory products of the adrenal glands, is cleared very slowly from the circulation with a t1/2 of 13.7 h and a metabolic clearance rate of 15.5 1/day. This slow metabolism is due, largely, to its strong binding to serum albumin, and its renal tubular reabsorption.
C Longcope
openaire   +3 more sources

Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity. [PDF]

J Intern Med
Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Park S, Park MJ, Yang HW, Park J, Yu SJ, Park SS, Choi MH, Cho EJ, Kim JH.   +8 more
europepmc   +2 more sources

Steroid alterations in Cushing’s disease persist after remission: ACTH-driven steroid changes dissociate from mood-regulatory neurosteroids [PDF]

Frontiers in Endocrinology
ObjectiveCushing’s disease (CD) is associated with high rates of depression and anxiety that often persist despite biochemical remission, yet the underlying mechanisms remain unclear. This study aims to characterize circulating neurosteroid (NS) profiles
Sebnem Burhan, Ebubekir Akpinar, Ebubekir Akpinar, Sevim Eyupoglu, Ayhan Bingol, Merve Korkmaz Yilmaz, Aslihan Pekmezci, Ebru Turgal, Huseyin Sehit Burhan, Mutlu Niyazoglu, Mutlu Niyazoglu, Esra Suheda Hatipoglu, Esra Suheda Hatipoglu   +12 more
doaj   +2 more sources

Comparing Hair Cortisol, DHEA, and Cortisol-to-DHEA Ratios from Various Body Sites in Anatolian Shelter Dogs [PDF]

Veterinary Sciences
Hair-based biomarkers offer a non-invasive window into chronic stress physiology, yet the influence of sampling body site on hair cortisol, dehydroepiandrosterone (DHEA), and their molar ratio has not been systematically characterized in domestic dogs ...
Jalil Ghassemi Nejad, Farzad Ghanbari, Si-Hyeong Sun   +2 more
doaj   +2 more sources

The neuroendocrine effects of dehydroepiandrosterone and 17β-estradiol in the in vitro preterm hyperoxia infant model [PDF]

Journal of Integrative Neuroscience, 2021
Preterm birth causes neurological deficits. Previously, we demonstrated that fetal zone steroids reduce hyperoxia-mediated cell death in vitro. In immature oligodendrocytes (OLN-93 cells), dehydroepiandrosterone + 17β-estradiol co-treatment had ...
Stephanie Hübner, Donna E. Sunny, Christine Zädow, Johanna Ruhnau, Bettina Reich, Antje Vogelgesang, Matthias Heckmann   +6 more
doaj   +1 more source

Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men [PDF]

Journal of Men's Health, 2021
Background: Both endothelial dysfunction and low circulating androgen levels predict cardiovascular disease in men. Endothelial function evaluation is commonly performed by measuring flow-mediated vasodilatation of the brachial artery.
Hiroshi Kumagai, Asako Zempo-Miyaki, Toru Yoshikawa, Kanae Myoenzono, Koichiro Tanahashi, Nobuhiko Akazawa, Seiji Maeda   +6 more
doaj   +1 more source

Dehydroepiandrosterone Attenuates Astroglial Activation, Neuronal Loss and Dendritic Degeneration in Iron-Induced Post-Traumatic Epilepsy

Brain Sciences, 2023
Iron-induced experimental epilepsy in rodents reproduces features of post-traumatic epilepsy (PTE) in humans. The neural network of the brain seems to be highly affected during the course of epileptogenesis and determines the occurrence of sudden and ...
Chandra Prakash, Shyam Sunder Rabidas, Jyoti Tyagi, Deepak Sharma   +3 more
doaj   +1 more source

Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model [PDF]

Iranian Journal of Medical Sciences, 2023
Background: Polycystic ovary syndrome (PCOS) is the most common reproductive dysfunction in premenopausal women. PCOS is associated with oxidative stress (OS), which is the main risk factor for renal diseases.
Nima Forghani, Zeinab Karimi, Mokhtar Mokhtari, Mehrdad Shariati, Fatemeh Masjedi   +4 more
doaj   +1 more source

Low serum dehydroepiandrosterone is associated with diabetic dyslipidemia risk in males with type 2 diabetes

Frontiers in Endocrinology, 2023
ObjectiveSex steroid hormones are associated with the advancement of metabolic diseases such as dyslipidemia. This cross-sectional study aimed to investigate the relationship between dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione,
Shanshan Chen, Shuo Li, Xinxin Zhang, Yuxin Fan, Ming Liu   +4 more
doaj   +1 more source