Results 1 to 10 of about 39,056 (236)

Dehydroepiandrosterone and Its CYP7B1 Metabolite 7α-Hydroxydehydroepiandrosterone Regulates 11β-Hydroxysteroid Dehydrogenase 1 Directions in Rat Leydig Cells

Frontiers in Endocrinology, 2020
Background: The purpose of this study was to investigate cytochrome P450-7B1 (CYP7B1) in the human and rat testes to regulate 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activity.
Qiqi Zhu, Yaoyao Dong, Xiaoheng Li, Chaobo Ni, Tongliang Huang, Jianliang Sun, Ren-Shan Ge   +6 more
doaj   +1 more source

RETRACTED: Abnormal Plasma Levels of Steroids and Their Ratios in Patients With Prurigo Nodularis: A Pilot Study

Frontiers in Physiology, 2022
Background: It has been suggested that cortisol levels are abnormal in chronic urticaria and atopic dermatitis, but other steroids, such as dehydroepiandrosterone (DHEA) and testosterone, are still unknown, and whether these hormones affect the ...
Liuxi Chu, Liuxi Chu, Liuxi Chu, Xin Shu, Yan Wu, Yan Wu, Yan Wu, Haoran Yang, Haoran Yang, Haoran Yang, Qin Lu, Qin Lu, Huihua Deng, Huihua Deng, Huihua Deng   +14 more
doaj   +1 more source

Effects of dehydroepiandrosterone supplementation on women with poor ovarian response: A preliminary report and review

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: To investigate the effect of dehydroepiandrosterone (DHEA) supplementation on women with poor ovarian response (POR). Materials and methods: Women with POR treated with flexible daily gonadotropin-releasing hormone antagonist in vitro ...
Kuan-Hao Tsui, Li-Te Lin, Renin Chang, Ben-Shian Huang, Jiin-Tsuey Cheng, Peng-Hui Wang   +5 more
doaj   +1 more source

The Utilization of Dehydroepiandrosterone as a Sexual Hormone Precursor in Premenopausal and Postmenopausal Women: An Overview

Pharmaceuticals, 2021
Dehydroepiandrosterone (DHEA), and its metabolite, dehydroepiandrosterone sulfate ester (DHEAS), are the most abundant circulating steroid hormones, and are synthesized in the zona reticularis of the adrenal cortex, in the gonads, and in the brain.
Justine Tang, Li-Ru Chen, Kuo-Hu Chen
doaj   +1 more source

Effects of Wash Protocol and Contamination Level on Concentrations of Cortisol and Dehydroepiandrosterone (DHEA) in Swine Hair

Animals, 2021
The effect of washing procedure and contamination level on the concentrations of cortisol and dehydroepiandrosterone (DHEA) in swine hair was explored over two studies.
Darian S. Pollock, David M. Janz, Diego Moya, Yolande M. Seddon   +3 more
doaj   +1 more source

DHEA Supplementation Confers No Additional Benefit to that of Growth Hormone on Pregnancy and Live Birth Rates in IVF Patients Categorized as Poor Prognosis

Frontiers in Endocrinology, 2018
BackgroundIn vitro fertilization (IVF) patients receive various adjuvant therapies to enhance success rates, but the true benefit is actively debated. Growth hormone (GH) and dehydroepiandrosterone (DHEA) supplementation were assessed in women undergoing
Kevin N. Keane, Kevin N. Keane, Peter M. Hinchliffe, Philip K. Rowlands, Gayatri Borude, Shanti Srinivasan, Satvinder S. Dhaliwal, John L. Yovich, John L. Yovich   +8 more
doaj   +1 more source

Low serum dehydroepiandrosterone levels are associated with diabetic retinopathy in patients with type 2 diabetes mellitus

Journal of Diabetes Investigation, 2023
Aims This cross‐sectional study assessed the association of serum dehydroepiandrosterone levels with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus in China.
Xinxin Zhang, Yadi Huang, Ning Xu, Wenli Feng, Jingting Qiao, Ming Liu   +5 more
doaj   +1 more source

Injurious Effect of Cisplatin on the Function of Hypothalamus-pituitary-adrenal/gonadal Axis in Mice and the Intervention Effect of Dehydroepiandrosterone

Shiyan dongwu yu bijiao yixue, 2023
Objective To study the pathway of cis-dichlorodiamineplatinum (DDP) inhibiting the synthesis of steroid hormones in mice, and to observe the intervention effect of dehydroepiandrosterone (DHEA).
PAN Zhiqiang, NONG Zixin, XIE Haina, PENG Peike   +3 more
doaj   +1 more source

An Improved Dehydroepiandrosterone-Induced Rat Model of Polycystic Ovary Syndrome (PCOS): Post-pubertal Improve PCOS's Features

Frontiers in Endocrinology, 2018
Complete animal models investigating the pathogenesis and treatment of polycystic ovarian syndrome (PCOS) are not completely established. Although dehydroepiandrosterone (DHEA)-induced pre-pubertal rat model for PCOS has been widely used, the model ...
Eun-Jeong Kim, Eun-Jeong Kim, Minhee Jang, Jong Hee Choi, Jong Hee Choi, Kyoung Sun Park, Ik-Hyun Cho, Ik-Hyun Cho, Ik-Hyun Cho   +8 more
doaj   +1 more source

Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency

Pharmaceuticals, 2018
The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone.
Mónica Fernández-Cancio, Núria Camats, Christa E. Flück, Adam Zalewski, Bernhard Dick, Brigitte M. Frey, Raquel Monné, Núria Torán, Laura Audí, Amit V. Pandey   +9 more
doaj   +1 more source