Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Alzheimer's Disease: A Systematic Review and Meta-Analysis [PDF]
Frontiers in Aging Neuroscience, 2019 Background and Purpose: Previous studies found inconsistent results for the relationship between Alzheimer's disease and the levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate.
Xiongfeng Pan +2 more
exaly +4 more sources
Relationship of body composition with cortisol and dehydroepiandrosterone sulfate levels in Korean men and women [PDF]
Journal of International Medical ResearchBackground Glucocorticoids, primarily cortisol, mediated by the hypothalamic–pituitary–adrenal axis, significantly influence metabolic responses, including insulin resistance, lipolysis, and body fat distribution.
Sat Byul Park
doaj +2 more sources
Low serum dehydroepiandrosterone is associated with diabetic dyslipidemia risk in males with type 2 diabetes [PDF]
Frontiers in Endocrinology, 2023 ObjectiveSex steroid hormones are associated with the advancement of metabolic diseases such as dyslipidemia. This cross-sectional study aimed to investigate the relationship between dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione,
Shanshan Chen +4 more
doaj +2 more sources
The metabolism of dehydroepiandrosterone sulfate and dehydroepiandrosterone
Aging Male, 1998 Dehydroepiandrosterone sulfate (DHEAS), one of the major secretory products of the adrenal glands, is cleared very slowly from the circulation with a t1/2 of 13.7 h and a metabolic clearance rate of 15.5 1/day. This slow metabolism is due, largely, to its strong binding to serum albumin, and its renal tubular reabsorption.
C Longcope
exaly +2 more sources
PharmaceuticalsDehydroepiandrosterone and its sulfate are the most abundant steroids in humans. The metabolism of dehydroepiandrosterone can differ significantly depending on the organ or tissue and the subtype of steroid receptors expressed in it.
Tatiana A. Fedotcheva +3 more
doaj +2 more sources
Hypoxia and dehydroepiandrosterone in old age: a mouse survival study [PDF]
Respiratory Research, 2006 Background Survival remains an issue in pulmonary hypertension, a chronic disorder that often affects aged human adults. In young adult mice and rats, chronic 50% hypoxia (11% FIO2 or 0.5 atm) induces pulmonary hypertension without threatening life.
Quillard Janine +2 more
doaj +2 more sources
The neuroendocrine effects of dehydroepiandrosterone and 17β-estradiol in the in vitro preterm hyperoxia infant model [PDF]
Journal of Integrative Neuroscience, 2021 Preterm birth causes neurological deficits. Previously, we demonstrated that fetal zone steroids reduce hyperoxia-mediated cell death in vitro. In immature oligodendrocytes (OLN-93 cells), dehydroepiandrosterone + 17β-estradiol co-treatment had ...
Stephanie Hübner +6 more
doaj +1 more source
Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men [PDF]
Journal of Men's Health, 2021 Background: Both endothelial dysfunction and low circulating androgen levels predict cardiovascular disease in men. Endothelial function evaluation is commonly performed by measuring flow-mediated vasodilatation of the brachial artery.
Hiroshi Kumagai +6 more
doaj +1 more source
Brain Sciences, 2023 Iron-induced experimental epilepsy in rodents reproduces features of post-traumatic epilepsy (PTE) in humans. The neural network of the brain seems to be highly affected during the course of epileptogenesis and determines the occurrence of sudden and ...
Chandra Prakash +3 more
doaj +1 more source
Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model [PDF]
Iranian Journal of Medical Sciences, 2023 Background: Polycystic ovary syndrome (PCOS) is the most common reproductive dysfunction in premenopausal women. PCOS is associated with oxidative stress (OS), which is the main risk factor for renal diseases.
Nima Forghani +4 more
doaj +1 more source