Results 41 to 50 of about 39,361 (246)

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Dehydroepiandrosterone sulfate (DHEAS) is neuroprotective when administered either before or after injury in a focal cortical cold lesion model [PDF]

, 2006
Dehydroepiandrosterone and its sulfate (DHEAS) are sex hormone precursors that exert marked neurotrophic and/or neuroprotective activity in the central nervous system.
Toldi, József, Kis, Zsolt, Rózsa, Éva, Farkas, Tamás, Juhász-Vedres, Gabriella, Párducz, Árpád, Rákos, Gabriella, Wölfling, János, Dobszay B., Gábor   +8 more
core  

Subclinical cardiac alterations and cardiometabolic profile in adolescents with newly diagnosed polycystic ovary syndrome: A cross‐sectional comparative echocardiographic study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective While cardiometabolic comorbidities have been well established in adults with polycystic ovary syndrome (PCOS), it remains unclear whether the early signs of cardiovascular morbidity emerge during adolescence. This study aimed to investigate whether metabolic and cardiovascular alterations begin in adolescents with PCOS.
Demet Aygün Ari, Melis Pehlivantürk Kizilkan, Musa Öztürk, İlker Ertuğrul, Hayrettin Hakan Aykan, Tevfik Karagöz, Nuray Kanbur, Orhan Derman, Sinem Akgül   +8 more
wiley   +1 more source

Down-Regulation of Dehydroepiandrosterone Sulfotransferase Gene in Human Hepatocellular Carcinoma [PDF]

, 2008
Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down- regulation of a vital sex steroid precursor ( dehydroepiandrosterone sulfotransferase;
許輝吉, Huang, Lan-Ru; Coughtrie, Michael W.H.; Hsu, Hey-Chi   +1 more
core  

Steroid hormone levels in postmenopausal hysterectomised women with and without ovarian conservation: the continuous endocrine function of the ovaries

Journal of Obstetrics and Gynaecology, 2023
This study aims to clarify the effect of postmenopausal bilateral oophorectomy on plasma steroid hormone levels. Women who were submitted in the postmenopausal period to hysterectomy for uterine benign conditions were divided into two groups: 18 women ...
Elsa Nunes, Eugenia Gallardo, Sara Morgado-Nunes, José Fonseca-Moutinho   +3 more
doaj   +1 more source

Efficacy of dehydroepiandrosterone priming in women with poor ovarian response undergoing IVF/ICSI: a meta-analysis

Frontiers in Endocrinology, 2023
BackgroundDehydroepiandrosterone (DHEA) may improve the outcomes of patients with poor ovarian response (POR) or diminished ovarian reserve (DOR) undergoing IVF/ICSI. However, the evidence remains inconsistent.
Jie Zhang, Hongyan Jia, Hongyan Jia, Feiyang Diao, Xiang Ma, Jiayin Liu, Yugui Cui   +6 more
doaj   +1 more source

Maternal overweight and obesity during pregnancy and sex‐dependent dysregulation of the materno‐fetal stress axis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Maternal obesity and excess gestational weight gain (GWG) are linked to adverse perinatal outcomes, potentially via disruption of the maternal–fetal stress axis. Placental HSD11B2 protects the fetus from excess glucocorticoids and may influence fetal programming during maternal metabolic stress.
Thorsten Braun, Marie Hofmann, Rebecca Rancourt, Julia Sommer, Alexandra Kühn, Loreen Ehrlich, Thomas Ziska, Kerstin Melchior, Karen Schellong, Wolfgang Henrich, Sonja Entringer, Katherine Margaret Kennedy, Andreas Plagemann, Deborah Magdalena Sloboda   +13 more
wiley   +1 more source

Postnatal and postweaning endocrine setting in dairy calves through hair cortisol, dehydroepiandrosterone and dehydroepiandrosterone sulphate [PDF]

, 2022
Importance of the work: The care of calves on dairy farms between birth and weaning can improve their long-term development and growth. In fact, a poor newborn health status and a high allostatic load may adversely affect development in dairy cows.
Cotticelli A., Peric T., Prandi A., Montillo M., Comin A., Corazzin M., Spigarelli C.   +6 more
core   +1 more source

Dissociation of Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Septic Shock [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2006
Dehydroepiandrosterone (DHEA) replacement in sepsis has been advocated because of the sepsis-associated decrease in serum DHEA sulfate (DHEAS). However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels.The objective of the study was to test ...
Wiebke, Arlt, Fabian, Hammer, Petra, Sanning, Stephen K, Butcher, Janet M, Lord, Bruno, Allolio, Djillali, Annane, Paul M, Stewart   +7 more
openaire   +2 more sources

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source