Results 21 to 30 of about 33,998 (196)

An Improved Dehydroepiandrosterone-Induced Rat Model of Polycystic Ovary Syndrome (PCOS): Post-pubertal Improve PCOS's Features

Frontiers in Endocrinology, 2018
Complete animal models investigating the pathogenesis and treatment of polycystic ovarian syndrome (PCOS) are not completely established. Although dehydroepiandrosterone (DHEA)-induced pre-pubertal rat model for PCOS has been widely used, the model ...
Eun-Jeong Kim, Eun-Jeong Kim, Minhee Jang, Jong Hee Choi, Jong Hee Choi, Kyoung Sun Park, Ik-Hyun Cho, Ik-Hyun Cho, Ik-Hyun Cho   +8 more
doaj   +1 more source

Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency

Pharmaceuticals, 2018
The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone.
Mónica Fernández-Cancio, Núria Camats, Christa E. Flück, Adam Zalewski, Bernhard Dick, Brigitte M. Frey, Raquel Monné, Núria Torán, Laura Audí, Amit V. Pandey   +9 more
doaj   +1 more source

Low Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Are Associated With Coronary Heart Disease in Men With Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2022
AimsSex hormones play an important role in the pathogenesis of cardiovascular disease (CVD). This cross-sectional study aimed to explore the associations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) with coronary heart ...
Xinxin Zhang, Jinfeng Xiao, Tong Liu, Qing He, Jingqiu Cui, Shaofang Tang, Xin Li, Ming Liu   +7 more
doaj   +1 more source

Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human umbilical vein endothelial cells

Frontiers in Pharmacology
IntroductionThis study aimed to investigate the underlying mechanisms involved in the cardioprotective effects of dehydroepiandrosterone (DHEA) on endoplasmic reticulum stress (ERS) -mediated apoptosis in human vascular smooth muscle cells (HVSMCs) and ...
Ye Zhu, Junxiu Wei, Xin Yang, Wei Zhu
doaj   +1 more source

Androgen deficiency in women with adrenal insufficiency. Dehydroepiandrosterone. Review [PDF]

Гинекология, 2018
It is known that adrenal insufficiency (AI) is a severe life-threatening disease due to the exceptional role of glucocorticoids and mineralocorticoids in the human body. At the same time, according to some reports, the deficit of androgens synthesized by
N F Nuralieva, M Yu Yukina, E A Troshina, N M Platonova   +3 more
doaj   +1 more source

Beyond Glucocorticoids: Integrating Dehydroepiandrosterone (DHEA) into Animal Welfare Research

Animals, 2020
Animal welfare researchers are committed to identifying novel measures for enhancing the quality of life of individual animals. Recently, welfare scientists have emphasized the need for tracking multiple indicators of an animal’s behavioral, emotional ...
Jessica C. Whitham, Jocelyn L. Bryant, Lance J. Miller   +2 more
doaj   +1 more source

Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial

Life, 2020
Background: Only few studies have monitored the potential of physical activity training and physical therapy to modulate the reaction of the endocrine system.
Gabriela Angelova, Tereza Skodova, Terezie Prokopiusova, Magdalena Markova, Natalia Hruskova, Marie Prochazkova, Marketa Pavlikova, Sarka Spanhelova, Ivana Stetkarova, Marie Bicikova, Lucie Kolatorova, Kamila Rasova   +11 more
doaj   +1 more source

Supercritical Fluid Chromatography for Expedited Sample Clean‐Up in Isotope Ratio Mass Spectrometry Including Cholesterol as New Endogenous Reference Compound

Drug Testing and Analysis, EarlyView.
Supercritical fluid chromatography was employed in the sample preparation for IRMS determinations in sports drug testing for the first time and the developed method was successfully validated. Cholesterol (CHOL) was introduced as a novel endogenous reference compound and population‐based Δ‐values were established as shown here.
Thomas Piper, Jana Drewes, Mario Thevis
wiley   +1 more source

Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Alzheimer's Disease: A Systematic Review and Meta-Analysis

Frontiers in Aging Neuroscience, 2019
Background and Purpose: Previous studies found inconsistent results for the relationship between Alzheimer's disease and the levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate.
Xiongfeng Pan, Xinyin Wu, Atipatsa C. Kaminga, Atipatsa C. Kaminga, Shi Wu Wen, Shi Wu Wen, Aizhong Liu   +6 more
doaj   +1 more source

Efficacy of dehydroepiandrosterone priming in women with poor ovarian response undergoing IVF/ICSI: a meta-analysis

Frontiers in Endocrinology, 2023
BackgroundDehydroepiandrosterone (DHEA) may improve the outcomes of patients with poor ovarian response (POR) or diminished ovarian reserve (DOR) undergoing IVF/ICSI. However, the evidence remains inconsistent.
Jie Zhang, Hongyan Jia, Hongyan Jia, Feiyang Diao, Xiang Ma, Jiayin Liu, Yugui Cui   +6 more
doaj   +1 more source