Results 11 to 20 of about 798 (134)
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis +2 more
wiley +2 more sources
Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu +3 more
wiley +2 more sources
Microbial Modifications of Androstane and Androstene Steroids by Penicillium vinaceum [PDF]
Molecules, 2020 The biotransformation of steroid compounds is a promising, environmentally friendly route to new pharmaceuticals and hormones. One of the reaction types common in the metabolic fate of steroids is Baeyer-Villiger oxidation, which in the case of cyclic ketones, such as steroids, leads to lactones. Fungal enzymes catalyzing this reaction, Baeyer-Villiger
Anna Panek +2 more
openaire +3 more sources
Advanced Science, Volume 13, Issue 25, 4 May 2026.The rational design of Ni3+‐rich active sites on nickel nitride nanosheets via Pd‐induced electronic modulation, which was employed in the electrooxidation of sterol coupled with H2 production in a large flow electrolyzer. This work offers a novel strategy for the design and synthesis of highly efficient electrocatalysts and electrolyzers toward the ...
Suiqin Li +11 more
wiley +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández +6 more
wiley +1 more source
Design, Synthesis and Molecular Modeling Studies of Triazole Derivatives as Aromatase İnhibitors
Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.In this study, a new series of 1,3,4‐triazole derivative compounds was designed and synthesized. The cytotoxicity of these synthesized compounds on the breast cancer cell line MCF‐7 was determined by the MTT method. The enzyme inhibition potentials of compounds 3ı, 3g, 3n, and 3m, which are effective on both MCF‐7 and the aromatase enzyme, were ...
Emine Rana Bağcı +5 more
wiley +1 more source
Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source
Food Frontiers, Volume 7, Issue 2, March 2026.Enzyme‐treated Polygonatum odoratum extract (ETP) was more effective than the conventional extract in mitigating cyclophosphamide‐induced immunotoxicity. The underlying mechanism involves the alleviation of oxidative stress, inflammation, and gut dysbiosis, coupled with the restoration of immune homeostasis, which is potentially associated with the ...
Qing Liu +9 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.ABSTRACT Breast cancer remains a leading cause of female mortality, largely sustained by local oestrogen production. The enzyme 17β‐hydroxysteroid dehydrogenase type 1 (17β‐HSD1) is an enzyme involved in the oestrogen biosynthesis pathway, particularly in the conversion of estrone to estradiol, and is overexpressed in conditions such as breast cancer ...
Emad Rashad Sindi +9 more
wiley +1 more source
ChemistryOpen, Volume 14, Issue 9, September 2025.Two genetically modified strains are designed and constructed to produce 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one (4‐HBC) and 3‐oxo‐4,17‐pregnadiene‐20‐carboxylic acid methyl ester (PDCE) by disrupting and overexpressing the aldolase gene (thl) in the genetically modified strains of Mycolicibacterium neoaurum NRRL B‐3805, respectively, which are useful ...
Xuemei Li +8 more
wiley +1 more source