Results 21 to 30 of about 798 (134)

Improving the Determination of Carbon Isotope Ratios of Endogenous Steroids Found in Human Serum

Drug Testing and Analysis, Volume 17, Issue 7, Page 944-953, July 2025.
A method employing high‐performance liquid chromatographic sample cleanup to determine the carbon isotope ratios of steroids found in human serum was developed and fully validated. A reference population encompassing more than 120 male and female athlete samples was investigated in order to establish population‐based thresholds for Δ‐values.
Thomas Piper, Mario Thevis
wiley   +1 more source

Multiyear Baleen Endocrine Profiles Suggest a Longer Estimated Gestation in Southern Right Whales (Eubalaena australis)

Ecology and Evolution, Volume 15, Issue 6, June 2025.
Multiyear profiles of progesterone and estrogen in the baleen of adult female southern right whales indicate progesterone elevations lasting on average between 20 and 25 months, indicative of pregnancies longer than previously estimated. These data are in line with endocrine profiles in baleen of other Balaenid whales incl.
Loraine Shuttleworth, Andre Ganswindt, Kathleen E. Hunt, Alejandro Fernández Ajó, Estefan Pieterse, S. Mduduzi Seakamela, Chantel Schoeman, Els Vermeulen   +7 more
wiley   +1 more source

C‐type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
This study demonstrated that CNP stimulates human granulosa cell proliferation and the potential for cross‐talk between these cells and oocytes. Further research on the simultaneous administration of CNP and E2 may offer a potential avenue for promoting early‐stage follicle development in infertility treatments for patients with poor ovarian reserve ...
Yorino Sato, Kazuhiro Kawamura
wiley   +1 more source

Coumarin‐Based Aldo‐Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors

ChemMedChem, Volume 19, Issue 21, November 4, 2024.
The AKR1C family of enzymes are overexpressed in numerous cancers where they are involved in drug resistance development. Coumarin amide 3 a possessed IC50 values of 50 nM and 90 nM for AKR1C3 and AKR1C2, respectively, and exhibits ‘drug‐like’ metabolic stability and half‐life in human and mouse liver microsomes and plasma.
Sravan K. Jonnalagadda, Ling Duan, Louise F. Dow, Geetha P Boligala, Elizabeth Kosmacek, Kristyn McCoy, Rebecca Oberley‐Deegan, Yashpal Singh Chhonker, Darryl J. Murry, C. Patrick Reynolds, Barry J. Maurer, Trevor M. Penning, Paul C. Trippier   +12 more
wiley   +1 more source

Improving the production of 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one in Mycolicibacterium smegmatis

Microbial Biotechnology, Volume 17, Issue 8, August 2024.
Currently, one of the challenge of the steroid industry is to achieve the production of C22 intermediates, such as 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one (4‐HBC), from phytosterols by metabolic engineering avoiding the presence of by‐products contamination. C22 steroids are used for the synthesis of progesterone in the pharma industry.
Gabriel Hernández‐Fernández, Miguel G. Acedos, Isabel de la Torre, Juan Ibero, José L. García, Beatriz Galán   +5 more
wiley   +1 more source

Halo‐1,2,3‐triazoles: Valuable Compounds to Access Biologically Relevant Molecules

ChemBioChem, Volume 25, Issue 10, May 17, 2024.
1,4,5‐trisubstituted halo‐1,2,3‐triazoles are emerging scaffolds with a wide range of applications in the Life Science. In this review, we explore the synthesis, the functionalization, and the applications of halo‐triazole derivatives in biologically relevant molecules including nucleosides, carbohydrates, peptides and proteins. Abstract 1,2,3‐triazole
Dylan Coelho, Yoann Colas, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud, Laura Iannazzo   +4 more
wiley   +1 more source

Profiling of urinary steroids aided by lithium ion adduction‐based ultrahigh‐performance liquid chromatography–tandem mass spectrometry

Rapid Communications in Mass Spectrometry, Volume 38, Issue 9, 15 May 2024.
Rationale As 3‐OH‐containing steroids are prone to dehydration by conventional electrospray ionization, reducing detection sensitivity, Li ion adduction‐based ultrahigh‐performance liquid chromatography–tandem mass spectrometry (UHPLC/MS/MS), developed to prevent dehydration and effectively detect 3‐OH steroids, was applied for profiling total and free
Yue Pan, Qiuyi Wang, Mengyao Chen, Toshifumi Takao   +3 more
wiley   +1 more source

Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess

The FASEB Journal, Volume 38, Issue 7, 15 April 2024.
Co‐expression of the glucocorticoid‐activating enzyme HSD11B1 with the androgen‐activating enzyme AKR1C3 in adipose attenuates the biosynthesis of the 11‐oxygenated androgen, 11‐ketotestosterone. HSD11B1 inhibition leads to decreased local glucocorticoid activation but drives concurrent 11‐oxygenated androgen excess.
Lina Schiffer, Imken Oestlund, Jacky L. Snoep, Lorna C. Gilligan, Angela E. Taylor, Alexandra J. Sinclair, Rishi Singhal, Adrian Freeman, Ramzi Ajjan, Ana Tiganescu, Wiebke Arlt, Karl‐Heinz Storbeck   +11 more
wiley   +1 more source

Tumor proliferation associates with greater sensitivity to androgen receptor pathway inhibition in metastatic prostate cancer. [PDF]

J Clin Invest
Mendes L, Dutey-Magni PF, Grist E, Sachdeva A, Santos Vidal S, Lall S, Parry MA, Amos CL, Atako N, Wingate A, Wetterskog D, Sydes MR, Parker CC, Clarke N, Sweeney CJ, Parmar MK, Brown LC, James ND, Berney DM, Attard G.   +19 more
europepmc   +1 more source

The impact of abiraterone and enzalutamide on hypokalemia incidence in patients with prostate cancer: a systematic review and meta-analysis. [PDF]

BMC Cancer
Lou Y, Fan D, Chen T, Xiong K.
europepmc   +1 more source