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Autoimmune Pathogenesis and Autoimmune Hemolytic Anemia
Seminars in Hematology, 2005Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which autoantibodies are directed against an individual's own red blood cells (RBCs), leading to enhanced clearance through Fc receptor (FcR)-mediated phagocytosis. Although there is a large literature relating to clinical aspects of AIHA, relatively little work addresses how IgG ...
John W, Semple, John, Freedman
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Autoimmune hemolytic anemia: A history*
Transfusion Medicine Reviews, 2000UTOIMMUNE HEMOLYTIC anemia (AIHA) is an acquired immunoIogic disease in which the patient's red blood cells (RBCs) are selectively attacked and destroyed (hemolyzed) by autoantibodies produced by the patient's own immune system. These patients generally display the common symptoms of anemia: weakness, pallor, fatigue, and jaundice.
P, Mack, J, Freedman
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Reticulocytopenia in Autoimmune Hemolytic Anemia
Blood, 1956Abstract 1. In a series of 57 cases of autoimmune hemolytic anemia it was found that 25 or 44 per cent had a relative reticulocytopenia at times of hemolytic crisis. The mortality rate in this group was significantly higher than in those who showed a reticulocyte response consistent with the severity of anemia.
W H, CROSBY, H, RAPPAPORT
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Pediatric Clinics of North America, 1980
In autoimmune hemolytic anemia, individuals produce antibodies directed against one of their own erythrocyte membrane antigens. The hemolysis in autoimmune hemolytic anemia is most commonly extravascular rather than intravascular, and the liver and spleen play a major role in the clearance of the antibody-coated cells.
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In autoimmune hemolytic anemia, individuals produce antibodies directed against one of their own erythrocyte membrane antigens. The hemolysis in autoimmune hemolytic anemia is most commonly extravascular rather than intravascular, and the liver and spleen play a major role in the clearance of the antibody-coated cells.
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Autoimmune hemolytic anemia in adults: primary risk factors and diagnostic procedures
Expert Review of Hematology, 2020Introduction Autoimmune hemolytic anemia (AIHA) is due to autoantibodies against erythrocytes that may arise either because of primary tolerance breakage or along with several associated conditions, including genetic predispositions, congenital syndromes,
W. Barcellini, J. Giannotta, B. Fattizzo
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Human Pathology, 1983
Nowhere in the management of patients with autoimmune hemolytic anemias is the communication between clinician and laboratory personnel more important than in regard to blood transfusion. A clinical decision that blood transfusion is necessary must be tempered by the knowledge that transfusion has a greater-than-usual risk in this setting, both because
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Nowhere in the management of patients with autoimmune hemolytic anemias is the communication between clinician and laboratory personnel more important than in regard to blood transfusion. A clinical decision that blood transfusion is necessary must be tempered by the knowledge that transfusion has a greater-than-usual risk in this setting, both because
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Hospital Practice, 1985
Rh and ABO incompatibilities, drug reactions, and lupus are a few of the many causes of autoimmune hemolytic anemia. Among the determinants of autoimmunity involved are the class of the antibody, the biochemical composition of the antigen, the distribution of the antigen on the erythrocyte membrane, and the effector cells and molecules that are ...
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Rh and ABO incompatibilities, drug reactions, and lupus are a few of the many causes of autoimmune hemolytic anemia. Among the determinants of autoimmunity involved are the class of the antibody, the biochemical composition of the antigen, the distribution of the antigen on the erythrocyte membrane, and the effector cells and molecules that are ...
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AUTOIMMUNE HEMOLYTIC ANEMIA IN CHILDREN
Pediatric Hematology and Oncology, 2007The clinical and hematological profile and treatment outcome of children with warm autoimmune hemolytic anemia (AIHA) were assessed using retrospective case record analysis. There were 26 (17 idiopathic; 9 secondary) patients with a median age of 11 years. Pallor (100%), fever (39%), and jaundice (59%) were the main presenting complaints.
Rahul, Naithani +5 more
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Geoepidemiology of autoimmune hemolytic anemia
Autoimmunity Reviews, 2010Autoantibodies against red blood cell antigens are considered the diagnostic hallmark of AIHA: Direct antiglobulin test (DAT) completed by cytofluorometry and specific diagnostic monoclonal antibodies (mAbs) allow for a better understanding of autoimmune hemolytic anemia (AIHA) triggers. Once B-cell tolerance checkpoints are bypassed, the patient loses
Jean-Francois, Lambert, Urs E, Nydegger
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Archives of Internal Medicine, 1975
Warm-type autoantibodies of autoimmune hemolytic anemia (AIHA) are usually IgG but may be IgM or IgA. They are usual Rh specific. Cold-type antibodies are IgM or IgG (Donath-Landsteiner [DL] antibody). IgM antibodies are usually anit-l (occasionally anti-i) and DL antibodies anti-P.
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Warm-type autoantibodies of autoimmune hemolytic anemia (AIHA) are usually IgG but may be IgM or IgA. They are usual Rh specific. Cold-type antibodies are IgM or IgG (Donath-Landsteiner [DL] antibody). IgM antibodies are usually anit-l (occasionally anti-i) and DL antibodies anti-P.
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