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Postgraduate Medicine, 1978
Most, but not all, megaloblastic anemia is produced by "ineffective erythropoiesis" in the bone marrow due to either folic acid or vitamin B12 deficiency. In folic acid deficiency the cause frequently is inadequate dietary intake, whereas vitamin B12 deficiency is almost always conditioned by some specific type of malabsorption.
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Most, but not all, megaloblastic anemia is produced by "ineffective erythropoiesis" in the bone marrow due to either folic acid or vitamin B12 deficiency. In folic acid deficiency the cause frequently is inadequate dietary intake, whereas vitamin B12 deficiency is almost always conditioned by some specific type of malabsorption.
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Hyperpigmentation in Megaloblastic Anemia
International Journal of Dermatology, 1988ABSTRACT: Hyperpigmentation of the hands and feet developed in a 65–year–old Korean woman who had undergone a total gastrectomy and esophagojejunostomy due to early gastric cancer 7 years previously. A diagnosis of megaloblastic anemia due to vitamin B12deficiency was made.
Kyu Chuan Whang +4 more
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Diagnosis Of Megaloblastic Anemia
Annual Review of Medicine, 1991Megaloblastic anemia can be due to cobalamin deficiency, folate deficiency, or refractory forms of bone marrow disease. This essay reviews current thinking on the diagnostic procedures available to a physician considering these disorders. The questions to be answered are as follows: Is a megaloblastic anemia present?
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Hyperpigmentation in megaloblastic anemia
Journal of the American Academy of Dermatology, 1985Generalized hyperpigmentation developed over 2 years in a 65-year-old woman. A diagnosis of pernicious anemia was made, and treatment with vitamin B12 led to complete reversion of her hyperpigmentation to normal. Literature pertinent to hyperpigmentation and its association with megaloblastic anemias is reviewed and several possible mechanisms are ...
Robert A. Briggaman +2 more
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Megaloblastic Anemia in Pregnancy
Clinical Obstetrics and Gynecology, 1995Megaloblastic anemia is one of the acquired nutritional anemias that may complicate pregnancy. It is most often secondary to folic acid deficiency because folate requirements are increased during gestation. When the diagnosis of megaloblastic anemia is confirmed, appropriate therapy will initiate a rapid reversal of the anemia process.
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Drug-Induced Megaloblastic Anemia
New England Journal of Medicine, 2015Many common drugs induce megaloblastic anemia by interfering with folate or vitamin B12 absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a role. Supplements to overcome these effects or discontinuation of the drug may be necessary.
Chaker, Ben Salem +2 more
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2005
Publisher Summary In more than 95% of cases, megaloblastic anemia is as a result of folate and vitamin B12 deficiency. Megaloblastic anemias are characterized by the presence of megaloblasts in the bone marrow and macrocytes in the blood. Megaloblastic anemia may also result from rare inborn errors of metabolism of folate or vitamin B12.
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Publisher Summary In more than 95% of cases, megaloblastic anemia is as a result of folate and vitamin B12 deficiency. Megaloblastic anemias are characterized by the presence of megaloblasts in the bone marrow and macrocytes in the blood. Megaloblastic anemia may also result from rare inborn errors of metabolism of folate or vitamin B12.
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Megaloblastic anemia complicating thalassemia
The Indian Journal of Pediatrics, 1969Two cases of thalassaemia complicated by megaloblastic erythropoiesis are descrebed as occurring in infants aged 9 and 8 months. This association together with the causes of megaloblastosis in chronic hemolytic states have been discussed.
P. K. Sukumaran, N. Nagaratham
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Medical Clinics of North America, 2017
Vitamin B12 and folate deficiencies are major causes of megaloblastic anemia. Causes of B12 deficiency include pernicious anemia, gastric surgery, intestinal disorders, dietary deficiency, and inherited disorders of B12 transport or absorption. The prevalence of folate deficiency has decreased because of folate fortification, but deficiency still ...
Ananya Datta Mitra, Ralph Green
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Vitamin B12 and folate deficiencies are major causes of megaloblastic anemia. Causes of B12 deficiency include pernicious anemia, gastric surgery, intestinal disorders, dietary deficiency, and inherited disorders of B12 transport or absorption. The prevalence of folate deficiency has decreased because of folate fortification, but deficiency still ...
Ananya Datta Mitra, Ralph Green
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Bleeding manifestations in megaloblastic anemia
The Indian Journal of Pediatrics, 1989Ten children with megaloblastic anemia and a hemorrhagic diathesis are reported. Four of them had life-threatening bleeds necessitating an emergency blood transfusion. Seven had platelet counts of less than 30,000/cu mm, and nine had hemoglobin values of less than or equal to 5.2 g/dl at initial presentation.
Surjit Singh +5 more
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