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Causes and Pathophysiology of Acquired Sideroblastic Anemia
Genes, 2022 The sideroblastic anemias are a heterogeneous group of inherited and acquired disorders characterized by anemia and the presence of ring sideroblasts in the bone marrow.
Juan JOSÉ Rodríguez-Sevilla +2 more
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Therapeutische Umschau. Revue therapeutique, 2006 Sideroblastic anemias are a heterogenous group of disorders characterized by the presence of sideroblasts in the bone marrow aspirate. Current classification schemes distinguish between diseases of the heme synthesis pathway and diseases of other mitochondrial pathways which can either be of primary origin (defects in mitochondrial DNA) or of secondary
CAZZOLA, MARIO, INVERNIZZI, ROSANGELA
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Sideroblasts, Siderocytes, and Sideroblastic Anemia
New England Journal of Medicine, 1975SMALL iron-containing granules, demonstrable by means of the Prussian blue reaction, have been recognized in erythrocytes and their precursors for at least 30 years.1 2 3 4 5 Only recently, through the use of electron microscopy,6 7 8 have two distinct series of iron-containing erythroid cells been distinguished: one in which the iron consists of ...
G E, Cartwright, A, Deiss
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Meme biosynthesis in sideroblastic anemia
International Journal of Biochemistry, 1980Abstract The activities of δ-aminolevulinic acid synthase (ALA-S), δ-aminolevulinic acid dehydratase (ALA-D), uroporphyrinogen I synthase (Uro-I-S), uroporphyrinogen decarboxylase (Uro-DC) and heme synthase have been studied in peripheral red blood cells of 9 patients with hereditary sideroblastic anemia (HSA) and 8 patients with refractory ...
A V, Pasanen +3 more
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Cytogenetic studies in sideroblastic anemia
Cancer, 1976Cytogenetic studies were performed on bone marrow aspirates from seven patients with acquired sideroblastic anemia. In one male patient a 45,X cell line was present in each of three bone marrow aspirates. The remaining six patients had a normal chromosome complement. The abnormal stem line in the bone marrow may be unrelated to the hematologic disorder
M K, Jensen, M, Mikkelsen
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The molecular basis of the sideroblastic anemias
Current Opinion in Hematology, 1996The sideroblastic anemias display remarkable clinical and hematologic heterogeneity but share in common mitochondrial iron loading as evidence of unhinging between intracellular iron metabolism and heme biosynthesis. Molecular defects responsible for this unhinging have now been identified and appear to display matching heterogeneity.
E J, Fitzsimons, A, May
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Zinc abuse and sideroblastic anemia
American Journal of Hematology, 1993AbstractWe report the case of a young woman who presented with anemia and leukopenia. A bone marrow aspirate, revealed a marked excess of ringed sideroblasts. A detailed dietary history disclosed excessive zinc intake. High serum zinc and low serum copper concentrations were confirmed.
J, Ramadurai +3 more
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Sideroblastic anemia and development of leukemia
Blut, 1981In patients with refractory anemia it is important to count and classify the different sideroblasts (intermediate sideroblasts with more than six iron grains or ring sideroblasts), to study the cellularity of the bone marrow and disturbances in thrombo- and myelopoiesis, and to note previous exposure to mutagenic or other toxic agents.
R, Hast, P, Reizenstein
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Hematology Meeting Reports, 2009
The sideroblastic anemias are a heterogeneous group of inherited and acquired disorders characterized by anemia of varying severity and the presence of ringed sideroblasts in the bone marrow.1 These latter are immature red cells with iron-loaded mitochondria visualized by Prussian blue staining as a perinuclear ring of blue granules. The most common of
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The sideroblastic anemias are a heterogeneous group of inherited and acquired disorders characterized by anemia of varying severity and the presence of ringed sideroblasts in the bone marrow.1 These latter are immature red cells with iron-loaded mitochondria visualized by Prussian blue staining as a perinuclear ring of blue granules. The most common of
openaire +1 more source