Results 81 to 90 of about 7,817,858 (363)

A Transformer-based Prediction Method for Depth of Anesthesia During Target-controlled Infusion of Propofol and Remifentanil [PDF]

open access: yesarXiv, 2023
Accurately predicting anesthetic effects is essential for target-controlled infusion systems. The traditional (PK-PD) models for Bispectral index (BIS) prediction require manual selection of model parameters, which can be challenging in clinical settings. Recently proposed deep learning methods can only capture general trends and may not predict abrupt
arxiv  

Neuropsychological and Behavioral Outcomes after Exposure of Young Children to Procedures Requiring General Anesthesia: The Mayo Anesthesia Safety in Kids (MASK) Study

open access: yesAnesthesiology, 2018
Background: Few studies of how exposure of children to anesthesia may affect neurodevelopment employ comprehensive neuropsychological assessments. This study tested the hypothesis that exposure to multiple, but not single, procedures requiring anesthesia
D. O. Warner   +14 more
semanticscholar   +1 more source

Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial [PDF]

open access: yes, 2015
Background: Delirium is a common complication in elderly patients after surgery and associated with increased morbidity and mortality. Studies suggest that deep anesthesia and intense pain are important precipitating factors of postoperative delirium ...
Bin-Jiang Zhao   +15 more
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Evaluation of Dental Treatments in Children Performed under General Anesthesia

open access: yesBezmiâlem Science, 2018
Objective:This retrospective study aimed to evaluate the characteristics and treatment modalities of children whose dental treatments were performed under general anesthesia.Methods:The records of 196 children (107 boys and 85 girls), who were treated by
Meltem BAKKAL
doaj   +1 more source

General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis [PDF]

open access: yes, 2011
Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures. How anesthetic drugs create the state of general anesthesia is considered a major mystery of modern medicine ...
Brown, Emery N.   +2 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Lung (extracorporeal CO2 removal) and renal (continuous renal replacement therapy) support: the role of ultraprotective strategy in Covid 19 and non-Covid 19 ARDS. A case-control study

open access: yesJournal of Anesthesia, Analgesia and Critical Care
Background Preliminary studies suggest that moderate ARDS and acute renal failure might benefit from extracorporeal CO2 removal (ECCO2R) coupled with CRRT. However, evidence is limited and potential for this coupled treatment may need to be explored. The
Daniela Pasero   +13 more
doaj   +1 more source

Dissociative and analgesic properties of ketamine are independent and unaltered by sevoflurane general anesthesia

open access: yesPAIN Reports, 2021
. Introduction:. Ketamine, an anesthetic adjunct, is routinely administered as part of a balanced general anesthetic technique. We recently showed that the acute analgesic and dissociation properties of ketamine are separable to suggest that distinct ...
Eunice Y. Hahm   +10 more
doaj   +1 more source

Macaque's Cortical Functional Connectivity Dynamics at the Onset of Propofol-Induced Anesthesia [PDF]

open access: yesarXiv, 2021
Propofol, when administered for general anesthesia, induces oscillatory dynamic brain states that are thought to underlie the drug's pharmacological effects. Despite the elucidation of propofol's mechanisms of action at the molecular level, its effects on neural circuits and overall cortical functioning, which eventually lead to unconsciousness, are ...
arxiv  

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