Results 91 to 100 of about 72,384 (293)

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

open access: yesAdvanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song   +6 more
wiley   +1 more source

Comparative evaluation of economic effi ciency of modern inhaled anesthetics

open access: yesКачественная клиническая практика, 2018
The purpose of presented retrospective analysis was to identify retrospectively and estimate the economic benefits that can occur when comparing the costs of using desflurane or sevoflurane for anesthesia during surgery. Formalization and evaluation were
D. Yu. Belousov   +2 more
doaj  

OXYGEN DELIVERY, GASES AND ACID-BASE BALANCE OF ARTERIAL BLOOD DURING XENON ANESTHESIA OF THE CLOSED CIRCU

open access: yesВестник анестезиологии и реаниматологии, 2018
Xenon is an inert gas being very close to an ideal anesthetic. Goal of the study: to evaluate changes in gases and acid-base balance of arterial blood during general xenon anesthesia with the closed circuit and to compare it with general anesthesia with ...
A. Yu. Kulikov   +2 more
doaj   +1 more source

Cognitive dysfunction following desflurane versus sevoflurane general anesthesia in elderly patients: a randomized controlled trial. [PDF]

open access: yes, 2014
UnlabelledAs life expectancy increases, more patients ≥65 years undergo general anesthesia. Anesthetic agents may contribute to postoperative cognitive dysfunction, and incidence may differ with anesthetic agents or intraoperative anesthesia depth ...
Allard, Martin   +7 more
core   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser   +11 more
wiley   +1 more source

The effect of remimazolam-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia on emergence delirium in children undergoing tonsillectomy and adenoidectomy: study protocol for a prospective randomized controlled trial

open access: yesFrontiers in Pharmacology
Background: Remimazolam, a new ultrashort-acting benzodiazepine, is becoming increasingly applied in general anesthesia. This study is designed to investigate the effect of remimazolam-based total intravenous anesthesia and sevoflurane-based inhalation ...
Hong-Yu Ma   +19 more
doaj   +1 more source

The Effects of Changing from Isoflurane to Desflurane on the Recovery Profile during the Latter Part of Anesthesia [PDF]

open access: yes, 2010
It is not known whether changing from isoflurane to desflurane during the latter part of anesthesia shows early emergence and recovery in long surgery.
Baek, Chong-Wha   +8 more
core   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

open access: yesAdvanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang   +9 more
wiley   +1 more source

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

open access: yesAdvanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding   +14 more
wiley   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

open access: yesAdvanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li   +7 more
wiley   +1 more source

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