Results 121 to 130 of about 581,035 (306)

Tongxinluo enhances the effect of atorvastatin on the treatment of atherosclerosis with chronic obstructive pulmonary disease by maintaining the pulmonary microvascular barrier

Food Science &Nutrition, Volume 11, Issue 1, Page 390-407, January 2023., 2023
COPD aggravates AS, possibly through the destruction of pulmonary microvascular barrier function; thus, lung inflammation triggers systemic inflammation. In treating COPD with AS, TXL enhances the antiatherosclerotic effect of Ato, protecting the pulmonary microvascular barrier.
Xiangnan Kuang, Yafen Wang, Shiqiao Liu, Liping Chang, Yujie Yin, Zhen Li, Yi Liu, Wenyan Li, Yunlong Hou, Hongtao Wang, Junqing Liang, Zhenhua Jia   +11 more
wiley   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning

Glia, Volume 71, Issue 2, Page 415-430, February 2023., 2023
Main Points A subset of OPCs do not express Olig2, of which population peaks in the juvenile brain while wanes with age. Plastic changes of the brain by acute injuries or complex motor learning stop the expression of Olig2 in OPCs. Abstract Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain; however, their function ...
Li‐Pao Fang, Qing Liu, Erika Meyer, Anna Welle, Wenhui Huang, Anja Scheller, Frank Kirchhoff, Xianshu Bai   +7 more
wiley   +1 more source

FEATURES OF ANESTHESIA AT URGENT OPERATIVE INTERVENTIONS IN PATIENTS WITH THORACOABDOMINAL INJURIES

Медицинский вестник Юга России, 2016
Objective: identify the most acceptable options of anesthesia at urgent operative interventions concerning thoracoabdominal injuries depending on hemodynamic variables.
E. P. Sorokin, A. I. Gritsan, S. V. Ponomarev, Ye. V. Shilyaeva   +3 more
doaj   +1 more source

Nerves and Anesthesia: A physics perspective on medicine [PDF]

Anestezjologia i Ratownictwo 2014; 8: 252-263, 2014
We present a recent theory for nerve pulse propagation and anesthesia and argue that both nerve activity and the action of anesthetics can be understood on the basis of simple physical laws. It was found experimentally that biological membranes melt from a solid state to a liquid state just below physiological temperature. Such melting processes have a
arxiv  

Engineering Extracellular Vesicles Derived from 3D Cultivation of BMSCs Enriched with HGF Ameliorate Sepsis‐Induced Lung Epithelial Barrier Damage

Advanced Science, EarlyView.
3D culture of MSCs upregulates gene expression of matrix metalloproteinases (MMPs), growth factors (GFs), and increases the production of extracellular vesicles (EVs). Proteomic analysis reveals 642 upregulated proteins in 3D‐EVs, including HGF. These 3D‐EVs, enriched with HGF, protect lung epithelial cells from apoptosis and barrier damage in septic ...
Yong Chen, Feihong Lin, Tong Zhang, Zhuoran Xiao, Yuanli Chen, Dongsheng Hua, Yu Wang, Juan Wei, Tian Jin, Xin Lv   +9 more
wiley   +1 more source

The Modeling and Quantification of Rhythmic to Non-rhythmic Phenomenon in Electrocardiography during Anesthesia [PDF]

arXiv, 2015
Variations of instantaneous heart rate appears regularly oscillatory in deeper levels of anesthesia and less regular in lighter levels of anesthesia. It is impossible to observe this "rhythmic-to-non-rhythmic" phenomenon from raw electrocardiography waveform in current standard anesthesia monitors. To explore the possible clinical value, I proposed the
arxiv  

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

The unique challenges of Brugada syndrome in spinal deformity surgery

Interdisciplinary Neurosurgery, 2021
Brugada Syndrome (BrS) is a genetic condition associated with ventricular fibrillation and sudden cardiac death. In BrS, several pharmacological agents may increase the risk for arrhythmia and total intravenous anesthesia with propofol (TIVA) may be ...
F.G. Sigmundsson, J. Kuchalik, S. Fadl, M. Holy, A. Joelson   +4 more
doaj  

IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex

Advanced Science, EarlyView.
This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv, Wenzheng Zou, Lin Li, Shukui Zhang, Jiaqi Liang, Jiali Pu, Jianwei Jiao   +6 more
wiley   +1 more source