Results 121 to 130 of about 73,729 (291)

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

, 1972
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1077/thumbnail ...

core   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Interior Decorative VOCs Elevate T Cell‐Mediated Obstructive Lung Disease Risks via Osteogenesis‐Driven Lymphoid‐Biased Hematopoiesis

Advanced Science, EarlyView.
This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu, Jingxu Zhang, Qingping Liu, Duxing Li, Ruonan Pan, Gan Miao, Yidi Chen, Zhe Kou, Guangbo Qu, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

Dose N2O Cause Paradoxical Reaction in Response to Noxious Stimulants During Inhalation Induction of Anesthesia in Pediatrics?

مجله دانشکده پزشکی اصفهان, 2009
Background: Bispectral Index is one of the qualitative methods of measuring of sedation and depth of anesthesia. In a few studies appeared a paradoxical effect of N2O on BIS in adults.
Mohamad Golparvar, Alireza Koosha
doaj  

Successful transition from intravenous to inhalation anesthesia for respiratory management of coronavirus disease pneumonia: A case report

Acute Medicine & Surgery
Background In patients with coronavirus disease pneumonia, strong spontaneous breathing increases pulmonary vascular permeability and induces self‐inflicted lung injury, prolonging the intensive care unit stay and worsening prognosis.
Reijiro Kato, Yuhei Irie, Yoshito Izutani, Hiroyasu Ishikura   +3 more
doaj   +1 more source

Prospective Observational Study of Sympathetic Failure as a Mechanism Associated with Bradycardia During Induction of General Anesthesia in Children with Down Syndrome

Journal of Pediatric Research
Aim: While bradycardia in children with Down syndrome (DS) during inhalation induction of anesthesia is characteristic, its mechanism is not well understood.
Jamie Wingate Sinton, Sarah Marcum, Qing Duan, Kristie Geisler, David Cooper, Lili Ding, Jareen Meinzen-Derr, Susan Wiley, John McAuliffe   +8 more
doaj   +1 more source

Patient well‐being after general anaesthesia: a prospective, randomized, controlled multi‐centre trial comparing intravenous and inhalation anaesthesia [PDF]

, 2017
Background. The aim of this study was to assess postoperative patient well‐being after total i.v. anaesthesia compared with inhalation anaesthesia by means of validated psychometric tests. Methods.
Buddeberg, C., Büchi, S., Bühlmann, S., Hofer, C. K., Klaghofer, R., Pasch, T., Serafino, D., Spahn, D. R., Zollinger, A.   +8 more
core  

Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

Advanced Science, EarlyView.
Osteocyte heterogeneity in bone remains poorly understood. This study identifies six distinct osteocyte subsets in mice, revealing a key subpopulation (BHR‐Ocys) that drives bone loss in osteoporosis. BHR‐Ocys promote osteoclast‐mediated resorption via a novel Sema5a‐Plxna1 signaling axis.
Zengxin Jiang, Biyu Rui, Xuecheng He, Jiajun Wang, Xiangdong Wu, Rui Shao, Xue Meng, Xiaochun Peng, Hengfeng Yuan   +8 more
wiley   +1 more source

Barnes Hospital Record [PDF]

, 1964
https://digitalcommons.wustl.edu/bjc_barnes_record/1203/thumbnail ...

core   +1 more source