Results 131 to 140 of about 73,729 (291)
Advanced Science, EarlyView.The Single‐Nanostructured Optoelectronic Vehicle for neuromodulation Activation (SNOVA) establishes a paradigm for non‐genetic, implant‐free neuromodulation. By integrating NIR‐excitable UCNPs with broadband‐absorbing perovskite QDs, SNOVA efficiently converts deeply penetrating light into localized electric fields that modulate neuronal ion dynamics ...
Luyue Jiang +19 more
wiley +1 more source
Advanced Science, EarlyView.Metabolomics analyses reveal that trigonelline is markedly reduced in HFpEF hearts. Trigonelline supplementation alleviates metabolic disorders and improves cardiac function in HFpEF mice via gut microbiota‐mediated AMPK activation. Abstract Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular ...
Zhe Cheng +9 more
wiley +1 more source
General questions of anaesthesiology [PDF]
, 2015 This book covers information about basic principles and methods of the modern anesthesiology.
Ohiienko, Maksym Mykolaiovych +8 more
core
Advanced Science, EarlyView.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source
Nephrotoxicity of halogenated inhalational anaesthetics: Fictions and facts [PDF]
, 2002 Conzen, Peter F. +2 more
core +1 more source
12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture
Advanced Science, EarlyView.In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li +13 more
wiley +1 more source
Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat
Advanced Science, EarlyView.This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang +22 more
wiley +1 more source
Advanced Science, EarlyView.Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt +5 more
wiley +1 more source