Results 41 to 50 of about 5,386,243 (355)

Structural Modification in Anesthetic Drug Development for Prodrugs and Soft Drugs

Frontiers in Pharmacology, 2022
Among the advancements in drug structural modifications, the increased focus on drug metabolic and pharmacokinetic properties in the anesthetic drug design process has led to significant developments.
Chaoyi Deng, Chaoyi Deng, Jin Liu, Jin Liu, Wensheng Zhang, Wensheng Zhang   +5 more
doaj   +1 more source

Effect of vibration during local anesthesia administration on pain, anxiety, and behavior of pediatric patients aged 6–11 years: A crossover split-mouth study

Journal of dental anesthesia and pain medicine, 2019
Background Uncooperative behavior of children due to dental anxiety may interfere with the effective delivery of dental care and compromise the quality of treatment provided.
K. Hegde, Neeraja R, I. Srinivasan, Murali Krishna D R, Anjana M Melwani, Sreeraksha Radhakrishna   +5 more
semanticscholar   +1 more source

Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study

Frontiers in Microbiology, 2023
BackgroundPrevious studies have implicated a vital association between gut microbiota/gut microbial metabolites and low back pain (LBP), but their causal relationship is still unclear.
Mengchan Su, Mengchan Su, Yidan Tang, Yidan Tang, Weishuang Kong, Shuangyi Zhang, Shuangyi Zhang, Tao Zhu, Tao Zhu   +8 more
doaj   +1 more source

WALANT for distal radius fracture: open reduction with plating fixation via wide-awake local anesthesia with no tourniquet

Journal of Orthopaedic Surgery and Research, 2018
BackgroundThe wide-awake local anesthesia no tourniquet (WALANT) technique is applied during various hand surgeries. We investigated the perioperative variables and clinical outcomes of open reduction and internal fixation (ORIF) for distal radius ...
Ying-Cheng Huang, Chien‐Jen Hsu, Jenn-Huei Renn, K. Lin, Shan-Wei Yang, Y. Tarng, Wei-Ning Chang, Chun-Yu Chen   +7 more
semanticscholar   +1 more source

Multisite chronic pain and the risk of autoimmune diseases: A Mendelian randomization study

Frontiers in Immunology, 2023
BackgroundAccumulating evidence has demonstrated that an association between chronic pain and autoimmune diseases (AIDs). Nevertheless, it is unclear whether these associations refer to a causal relationship. We used a two-sample Mendelian randomization (
Yidan Tang, Yidan Tang, Weizhi Liu, Weizhi Liu, Weishuang Kong, Shuangyi Zhang, Shuangyi Zhang, Tao Zhu, Tao Zhu   +8 more
doaj   +1 more source

Monosynaptic Functional Connectivity in Cerebral Cortex During Wakefulness and Under Graded Levels of Anesthesia [PDF]

, 2012
The balance between excitation and inhibition is considered to be of significant importance for neural computation and cognitive function. Excitatory and inhibitory functional connectivity in intact cortical neuronal networks in wakefulness and graded ...
Diba, Kamran, Hudetz, Anthony G., Pillay, Siveshigan, Ropella, Kristina M., Vizuete, Jeannette A.   +4 more
core   +3 more sources

Interpleural analgesia with Morphine and Bupivacaine in pneumothorax

Universidad Médica Pinareña, 2019
Introduction:interpleural block offers postoperative analgesia with significant results in surgical interventions. Objective:to evaluate the benefits of interpleural block with 0.5 % Bupivacaine and Morphine by means of interpleural catheter in patients
Marcos Osuna Ramos, Alejandro Muñoz García, Adrián Alejandro Vitón-Castillo, Celia Fundora-González, Ana Lourdes Martínez Zamora   +4 more
doaj   +2 more sources

Resistance to local anesthesia in people with the Ehlers-Danlos Syndromes presenting for dental surgery

Journal of dental anesthesia and pain medicine, 2019
Background People with the Ehlers-Danlos Syndromes (EDS), a group of heritable disorders of connective tissue, often report experiencing dental procedure pain despite local anesthetic (LA) use.
J. Schubart, E. Schaefer, P. Janicki, S. Adhikary, Amber L. Schilling, A. Hakim, R. Bascom, C. Francomano, S. Raj   +8 more
semanticscholar   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Electroencephalographic depression after abruptly increasing partial pressure of end-tidal carbon dioxide: a case series

BMC Anesthesiology
Background Prolonged electroencephalographic depression during surgery is associated with poor outcomes for patients. However, the published literature on electroencephalographic depression caused by a sudden increase in the partial pressure of end-tidal
Shikuo Li, Yuyi Zhao, Qifeng Wang, Xuehan Li, Chao Chen, Yunxia Zuo   +5 more
doaj   +1 more source