Results 51 to 60 of about 296,076 (314)

Regional anesthesia to ameliorate postoperative analgesia outcomes in pediatric surgical patients: an updated systematic review of randomized controlled trials

, 2018
Regional anesthesia is becoming increasingly popular among anesthesiologists in the management of postoperative analgesia following pediatric surgery.
Castro Alves, Lucas J. [UNESP], Suh, Edward I., McCormick, Zachary L., Kendall, Mark C., De Oliveira, Gildasio S.   +4 more
core   +1 more source

Evaluation of pain during diagnostic and surgical minihysteroscopy under local anesthesia

, 2023
Introduction Hysteroscopy is currently considered the gold standard for the diagnosis and treatment of lesions in the uterine cavity and cervical canal.
Małgorzata Kampioni, Maciej Wilczak, Adrian Nowak, Adam Malinger, Karolina Chmaj-Wierzchowska   +4 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Thermodynamics of General and Local Anesthesia [PDF]

Biophysical Journal, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare, Sasse-Middelhoff, Henrike, Heimburg, Thomas   +2 more
openaire   +4 more sources

General Anesthesia Versus Local Anesthesia in Carotid Endarterectomy: A Systematic Review and Meta-Analysis

, 2020
The choice of anesthetic technique in carotid endarterectomy (CEA) has been controversial. This study compared the outcomes of general anesthesia (GA) and local anesthesia (LA) in CEA.Systematic review and meta-analysis of comparative studies.Hospitals ...
Sameh Dimitri, Ian Yu Young Kwan, Amer Harky, Marcus Ng, Dilan Sanli, Christiana Bithas, Ramasubramanyan Chandrasekar, Ragai Makar, Rashad Rahimli, Jeffrey Shi Kai Chan, Zlatka Belamaric, Thompson Ka Ming Kot   +11 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Rapid quantification and validation of etomidate and dexmedetomidine blood concentrations in rats using a novel portable mass spectrometer

Frontiers in Veterinary Science
In clinical anesthesia, precise dosing depends on feedback from blood drug concentrations. However, rapid tools for measuring these concentrations are currently limited.
Sicheng Liu, Sicheng Liu, Xiaoxiao Li, Xiaoxiao Li, Deying Gong, Yanhua Huang, Wensheng Zhang, Wensheng Zhang   +7 more
doaj   +1 more source

Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide

Frontiers in Pharmacology, 2022
Although local anesthetics (LAs) such as lidocaine have been traditionally used for pain relief, their antitumor activity has attracted more and more attentions in recent years.
Yang Yang, Yang Yang, Jiaxiao Sun, Fei Peng, Fei Peng, Haibei Liu, Haibei Liu, Guoyan Zhao, Guoyan Zhao, Junjie Chen, Wensheng Zhang, Wensheng Zhang, Feng Qiu, Feng Qiu   +13 more
doaj   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Effects of bolus injection rate on the pharmacodynamics and pharmacokinetics of propofol, etomidate and sufentanil in rats

Frontiers in Veterinary Science
IntroductionThe preclinical phase of innovative drug research and development involves a comprehensive assessment of multiple variables that may influence therapeutic outcomes and safety profiles.
Sicheng Liu, Sicheng Liu, Deying Gong, Xiaoxiao Li, Xiaoxiao Li, Feng Qiu, Feng Qiu, Wensheng Zhang, Wensheng Zhang   +8 more
doaj   +1 more source