Results 61 to 70 of about 6,534,475 (234)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Effects of bolus injection rate on the pharmacodynamics and pharmacokinetics of propofol, etomidate and sufentanil in rats

Frontiers in Veterinary Science
IntroductionThe preclinical phase of innovative drug research and development involves a comprehensive assessment of multiple variables that may influence therapeutic outcomes and safety profiles.
Sicheng Liu, Sicheng Liu, Deying Gong, Xiaoxiao Li, Xiaoxiao Li, Feng Qiu, Feng Qiu, Wensheng Zhang, Wensheng Zhang   +8 more
doaj   +1 more source

Efeitos do uso da adrenalina na anestesia local odontológica em portador de coronariopatia Effects of epinephrine in local dental anesthesia in patients with coronary artery disease

Arquivos Brasileiros de Cardiologia, 2007
FUNDAMENTO: A literatura é controversa no que se refere ao uso de vasoconstritores para anestesia local em cardiopatas, havendo preocupação com a indução de descompensação cardíaca.
Ricardo Simões Neves, Itamara Lucia Itagiba Neves, Dante Marcelo Artigas Giorgi, Cesar José Grupi, Luís Antonio Machado César, Whady Hueb, Max Grinberg   +6 more
doaj   +1 more source

Diplopia with local anesthesia

National Journal of Maxillofacial Surgery, 2011
A variety of local and systemic complications can occur during the administration of local anesthesia (LA). Diplopia is one of the very rare complications that follow a posterior superior alveolar (PSA) nerve block. This article describes a very rare case report and the possible mechanisms are discussed in detail.
Pragasm, Michael, Managutti, Anil
openaire   +3 more sources

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes

Acta Pharmaceutica Sinica B
While transient perioperative side effects of intravenous anesthetics are often tolerated, the persistent postoperative sequelae resulting from drug accumulation pose a critical threat to patient safety.
Yi Zhao, Wei Ai, Jieyu Zhao, Xi Yang, Wencheng Liu, Yaru Ma, Jianrui Mou, Ao Hai, Ran Ji, Yu Gan, Zhuang Miao, Shilong Hu, Zhenbo Huang, Jin Liu, Xianggen Liu, Jun Yang, Bowen Ke   +16 more
doaj   +1 more source

The Thermodynamics of General and Local Anesthesia [PDF]

Biophysical Journal, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare, Sasse-Middelhoff, Henrike, Heimburg, Thomas   +2 more
openaire   +4 more sources

Department of Anesthesia. University of Iowa. Spring 2012. [PDF]

, 2012
University of Iowa Department of Anesthesia ...

core  

Selected 2017 Highlights in Congenital Cardiac Anesthesia

, 2018
This article is a review of the highlights of pertinent literature published during the 12 months of 2017, which is of interest to the congenital cardiac anesthesiologist. Following a search of the US National Library of Medicine PubMed database, several
Walker, Scott G., Kussman, B. D., Nasr, V. G., Twite, M. D.   +3 more
core   +1 more source

COMPARISON OF EMPATHY LEVELS OF DENTISTRY STUDENTS AFTER TWO TEACHING STRATEGIES OF ADMINISTERING LOCAL ANESTHESIA

, 2022
: This research compared the student-to-student (STS) model of injection as a default teaching strategy for dentistry students and the non-classmate-as-patient model of injection in helping dental students acquire or increase their level of empathy. This
Erlyn A. Sana, Celian N. Teng, Maria Geraldine S. Chanco   +2 more
core   +1 more source