Results 71 to 80 of about 4,350,697 (248)

Chlorpromazine as a Possible Local Anesthetic in Dentistry

, 1971
The tranquilizer chlorpromazine has been shown to be a potent local anesthetic. In this study chlorpromazine was injected into the mandibular gingiva of dogs to study possible irritating effects on the oral tissue.
W.H. Bowles
core   +1 more source

Lipids in local anesthetic toxicity [PDF]

, 2015
INTRODUCTION: With the advent of long-lasting local anesthetics, local and regional anesthesia gained considerable impetus and the use of these techniques has become increasingly widespread.
Dreyer, Elisabeth, Oliveira, Thales Gê de, Melo, Marcos De Simone, Udelsmann, Artur, Bonfim, Matheus Rodrigues, Borsoi, Luís Fernando Affini   +5 more
core   +1 more source

Local Toxicity from Local Anesthetic Polymeric Microparticles

Anesthesia and Analgesia, 2013
BACKGROUND:Local tissue injury from sustained-release formulations for local anesthetics can be severe. There is considerable variability in reporting of that injury.
J. B. McAlvin, G. Reznor, Sahadev A Shankarappa, C. Stefanescu, D. Kohane   +4 more
semanticscholar   +1 more source

THE PHARMACOLOGY OF THE LOCAL ANESTHETICS [PDF]

Journal of the American Medical Association, 1919
Acute intoxication in man from the use of the local anesthetics is far more common than is indicated by the number of recorded cases. We undertook to investigate the causes of such intoxication, and sought to find means of avoiding it, or combating it when it arises.
openaire   +1 more source

The effects of preadministration of local anesthetic on pulsed radiofrequency

, 2018
Background/aim: Pulsed radiofrequency (PRF) has been reported to be a safe and reliable method for the management of a variety of chronic pain syndromes.
Kurcaloglu, Mustafa, Uyar, Meltem, Arici, Tulin, Koken, Idris Sevki, Arıcı, Tülin, Eyigor, Can, Uzuner, Bora   +6 more
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Potentially unsafe doses of local anesthetics in axillary brachial plexus block: A single-center retrospective cohort study.

PLoS ONE
Local anesthetic systemic toxicity is a rare but potentially life-threatening complication of regional anesthesia that can occur when high doses of local anesthetics are administered.
Mélanie Suppan, Caroline Flora Samer, Georges Louis Savoldelli   +2 more
doaj   +1 more source

Local anesthetic failure associated with inflammation: verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite

, 2008
Takahiro Ueno1, Hironori Tsuchiya2, Maki Mizogami1, Ko Takakura11Department of Anesthesiology, Asahi University School of Dentistry, Mizuho, Gifu, Japan; 2Department of Dental Basic Education, Asahi University School of Dentistry, Mizuho, Gifu ...
Maki Mizogami, Takahiro Ueno, Hironori Tsuchiya, Ko Takakura   +3 more
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Interaction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol: Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects

Anesthesiology Research and Practice, 2013
Despite a long history in medical and dental application, the molecular mechanism and precise site of action are still arguable for local anesthetics. Their effects are considered to be induced by acting on functional proteins, on membrane lipids, or on ...
H. Tsuchiya, M. Mizogami
semanticscholar   +1 more source

Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity

Molecules, 2017
The majority of currently used anesthetic agents are derived from or associated with natural products, especially plants, as evidenced by cocaine that was isolated from coca (Erythroxylum coca, Erythroxylaceae) and became a prototype of modern local ...
Hironori Tsuchiya
doaj   +1 more source

Intravenous lipid emulsion for treatment of local anesthetic toxicity

, 2010
M Caroline Kosh, April D Miller, Jill E Michels, , Department of Clinical Pharmacy and Outcomes Sciences, South Carolina College of Pharmacy, University of South Carolina Campus, Columbia, South Carolina, USADate of Preparation: 14th July 2010 Conflict ...
Jill E Michels, April D Miller, M Caroline Kosh   +2 more
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