Results 101 to 110 of about 460,880 (412)

The thermodynamics of general anesthesia [PDF]

, 2006
It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found ...
Abelho, Andrew D. Jackson, Boheim, Cantor, Cantor, Cantor, Cantor, Cruzeiro-Hansson, Ebel, Firestone, Firestone, Franks, Franks, Galla, Halsey, Heimburg, Heimburg, Jain, Johnson, Kamaya, Kaminoh, Kaminoh, Katz, Kendig, Kharakoz, Kinnunen, Kobatake, Kreienbühl, Langerman, Lee, Lee, Meyer, Moss, Overton, Papahadjopoulos, Peoples, Punnia-Moorthy, Ritchie, Roth, Silbey, Spyropoulos, Thomas Heimburg, Trudell, Träuble, Träuble, Urban, van de Vossenberg   +46 more
core   +4 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Effect of dipolar-angle on phospholipid assembly [PDF]

Phys. Rev. E 95, 062703 (2017), 2016
We report the effect of lipid head-group dipole orientation on phase behaviour of phospholipid assembly. The work explains molecular-scale mechanism of ion-lipid, anesthetic-lipid interactions where reorientation of dipoles play important role in membrane potential modification. Molecular Dynamics simulations are performed to analyse structure-property
arxiv   +1 more source

Interacting Turing-Hopf Instabilities Drive Symmetry-Breaking Transitions in a Mean-Field Model of the Cortex: A Mechanism for the Slow Oscillation [PDF]

, 2013
Electrical recordings of brain activity during the transition from wake to anesthetic coma show temporal and spectral alterations that are correlated with gross changes in the underlying brain state. Entry into anesthetic unconsciousness is signposted by
Sleigh, James W., Steyn-Ross, D. Alistair, Steyn-Ross, Moira L.   +2 more
core   +3 more sources

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Mentol e eugenol como substitutos da benzocaína na indução anestésica de juvenis de pacu = Menthol and eugenol as benzocaine substitutes in anesthetic induction of pacu juveniles

Acta Scientiarum: Animal Sciences, 2008
Objetivou-se verificar a eficiência de anestésicos naturais na indução à anestesia de juvenis de pacu. Foram avaliadas quatro concentrações de mentol (50, 100, 150 e 200 mg L-1), quatro de eugenol (10, 25, 50 e 100 mg L-1) e uma de benzocaína (100 mg L-1)
André Fernando Nascimento Gonçalves, Elane Cristine Correia Santos, João Batista Kochenborger Fernandes, Leonardo Susumu Takahashi   +3 more
doaj  

Use of Injectable Eugenol for Euthanasia and Anesthesia of American Lobsters (Homarus Americanus) and Similar Species [PDF]

, 2012
Crustaceans are economically and ecologically significant, but current treatment and diagnostic protocols for crustacean health are limited. According to standards given by the American Veterinary Medical Association there are no current methods of ...
Huntsberger, Carlton
core   +1 more source

Ropivacaine vs tetracaine in topical anesthesia for intravitreal injection [PDF]

, 2015
Aim: The object of the study was to evaluate the long term efficacy and safety of ropivacaine 0,5% vs tetracaine 0,5% for topical anesthesia in intravitreal injection of dexamethasone in patients with diabetic macular edema (DME) and anti-vascular ...
COLLINI, Saul, PACELLA, Elena, PACELLA, FERNANDA, SALDUCCI, Mauro, SMALDONE, GIANPAOLO, Troisi, Fabiana, TURCHETTI, PAOLO   +6 more
core   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Qualitative and Quantitative Characteristics of the Electroencephalogram in Normal Horses during Administration of Inhaled Anesthesia. [PDF]

, 2015
BackgroundThe effects of anesthesia on the equine electroencephalogram (EEG) after administration of various drugs for sedation, induction, and maintenance are known, but not that the effect of inhaled anesthetics alone for EEG recording.ObjectiveTo ...
Aleman, M, Brosnan, RJ, Fletcher, DJ, Holliday, TA, Kass, PH, LeCouteur, RA, Steffey, EP, Tharp, B, Williams, DC   +8 more
core   +1 more source