Results 61 to 70 of about 223,198 (317)

THE AMOUNT OF THE ANESTHETIC. [PDF]

JAMA: The Journal of the American Medical Association, 1900
The anesthetic is undoubtedly a prominent etiologic factor in the disturbances which accompany and follow surgcal operations. To it may be attributed, directly or indirectly, much of the rapid pulse and respiration, exhaustion, shock, nausea, vomiting, asphyxia, syncope, bronchitis, pneumonia, pulmonary edema, and nephritis seen in connection with ...
openaire   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

THE ADMINISTRATION OF ANESTHETICS. [PDF]

JAMA: The Journal of the American Medical Association, 1898
A man who desires to study medicine can find many places in Chicago where they will undertake to teach him, but I do not know of any place where they will teach him to administer anesthetics. There are many places where he may learn but no place where any provision is made for properly teaching the subject. The student is not left to his own resources
openaire   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Enhanced efficacy of Magnolia denudata essential oil in fish anesthesia using nanoemulsions and self-microemulsifying drug delivery systems

Frontiers in Veterinary Science
IntroductionThe use of plant essential oils as anesthetics for fish has gained increasing attention, but ethanol, often used as a co-solvent, presents certain limitations.
Xiangbing Zeng, Xiangbing Zeng, Hongbiao Dong, Hongbiao Dong, Xiaoting Zheng, Xiaoting Zheng, Jiasong Zhang, Jiasong Zhang   +7 more
doaj   +1 more source

Chiral Alkyl Halides: Underexplored Motifs in Medicine

Marine Drugs, 2016
While alkyl halides are valuable intermediates in synthetic organic chemistry, their use as bioactive motifs in drug discovery and medicinal chemistry is rare in comparison. This is likely attributable to the common misconception that these compounds are
Bálint Gál, Cyril Bucher, Noah Z. Burns   +2 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Preparation and Characterization of Eugenol and 1,8-Cineole Nanoemulsions for Enhancing Anesthetic Activity in Guppy Fish (Poecilia reticulata)

Macromol
This study aimed to prepare and characterize nanoemulsions containing eugenol and 1,8-cineole using the emulsification method and to investigate their anesthetic effects on guppy fish.
Surachai Pikulkaew, Saransiri Nuanmanee, Banthita Saengsitthisak, Kantaporn Kheawfu, Charatda Punvittayagul, Wasana Chaisri   +5 more
doaj   +1 more source