Results 1 to 10 of about 1,731 (219)

Assessment of serum enzymatic markers of cardiomyocytes injury in female dogs submitted to ketamine S(+), atropin and xylazine association Mensuração da atividade sérica de marcadores de lesão cardíaca em cadelas anestesiadas com cetamina S(+), atropina e xilazina

Acta Cirúrgica Brasileira, 2009
PURPOSE: To assessment of the aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase isoenzyme fraction MB (CK-MB) serum activity in female dogs anesthetized with ketamine S (+), atropine and xylazine in several associations. METHODS:
Leandro Guimarães Franco, Maria Clorinda Soares Fioravanti, Adilson Donizeti Damasceno, Aline Cardoso Borges, Lorena Karine Soares, Rogério Elias Rabelo, Luiz Antônio Franco da Silva   +6 more
doaj   +1 more source

Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution

Frontiers in Human Neuroscience, 2017
There is converging evidence that high doses of hallucinogenic drugs can produce significant alterations of self-experience, described as the dissolution of the sense of self and the loss of boundaries between self and world.
Raphaël Millière
doaj   +1 more source

Low-dose Ketamine Does Not Improve Migraine in the Emergency Department: A Randomized Placebo-controlled Trial

Western Journal of Emergency Medicine, 2018
Introduction: Patients frequently present to the emergency department (ED) with migraine headaches. Although low-dose ketamine demonstrates analgesic efficacy for acute pain complaints in the ED, headaches have historically been excluded from these ...
Ashley R. Etchison, Lia Bos, Meredith Ray, Kelly B. McAllister, Moiz Mohammed, Barrett Park, Allen Vu Phan, Corey Heitz   +7 more
doaj   +1 more source

Neurotoxicity mechanisms and clinical implications of six common recreational drugs

Frontiers in Pharmacology
The recreational abuse of addictive drugs poses considerable challenges to public health, leading to widespread neurotoxicity and neurological dysfunction.
Jing Wang, Yulei Hao, Di Ma, Liangshu Feng, Feng Yang, Pingxu An, Xingqi Su, Jiachun Feng   +7 more
doaj   +1 more source

Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
Efeitos da infusão intravenosa contínua de fármacos anestésicos ou analgésicos sobre a anestesia geral com isoflurano: Estudo retrospectivo em 200 cães

Semina: Ciências Agrárias, 2013
Constant rate infusion (CRI) shows several advantages in balanced anesthesia, such as reduction of requirement for inhaled anesthetics and control of pain.
Sofia de Amorim Cerejo, Ewaldo de Mattos Júnior, Lilian Toshiko Nishimura, Carolina Quarterone, Leandro Guimarães Franco   +4 more
doaj   +1 more source

Inhibition of rabies virus transcription in rat cortical neurons with the dissociative anesthetic ketamine [PDF]

Antimicrobial Agents and Chemotherapy, 1992
In a previous study (B. P. Lockhart, H. Tsiang, P. E. Ceccaldi, and S. Guillemer, Antiviral Chem. Chemother. 2:9-15, 1991), we demonstrated an antiviral effect of the general anesthetic ketamine for rabies virus in neuronal cultures and in rat brain. This report describes an attempt to determine at what level ketamine acts on the rabies virus cycle in ...
Lockhart, B, Tordo, N, Tsiang, H
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The Discriminative Stimulus Properties of Hallucinogenic and Dissociative Anesthetic Drugs

, 2016
The subjective effects of drugs are related to the kinds of feelings they produce, such as euphoria or dysphoria. One of the methods that can be used to study these effects is the drug discrimination procedure. Many researchers have been trying to elucidate the mechanisms that underlie the discriminative stimulus properties of abused drugs (e.g ...
Tomohisa, Mori, Tsutomu, Suzuki
openaire   +2 more sources

Combined effects of dissociable and undissociable local anesthetics upon ATP-induced firefly bioluminescence. [PDF]

Proceedings of the National Academy of Sciences, 1976
Combined effects of two drugs present simultaneously are usually expressed as summation, synergism or potentiation, and antagonism. When the sum of the effects of each drug present separately equals the combined effect of the two drugs present simultaneously, the action is called additive or summation.
H, Kamaya, I, Ueda, H, Eyring
openaire   +2 more sources

Exploring Novel Antidepressants Targeting G Protein-Coupled Receptors and Key Membrane Receptors Based on Molecular Structures

Molecules
Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities.
Hanbo Yao, Xiaodong Wang, Jiaxin Chi, Haorong Chen, Yilin Liu, Jiayi Yang, Jiaqi Yu, Yongdui Ruan, Xufu Xiang, Jiang Pi, Jun-Fa Xu   +10 more
doaj   +1 more source

Epigenetic mechanisms of rapid-acting antidepressants

Translational Psychiatry
Background Rapid-acting antidepressants (RAADs), including dissociative anesthetics, psychedelics, and empathogens, elicit rapid and sustained therapeutic improvements in psychiatric disorders by purportedly modulating neuroplasticity, neurotransmission,
Antonio Inserra, Antonella Campanale, Tamim Rezai, Patrizia Romualdi, Tiziana Rubino   +4 more
doaj   +1 more source