Results 21 to 30 of about 6,244,144 (279)
Insights into the interaction dynamics between volatile anesthetics and tubulin through computational molecular modelling [PDF]
, 2021 General anesthetics, able to reversibly suppress all conscious brain activity, have baffled medical science for decades, and little is known about their exact molecular mechanism of action.
Eric A. Zizzi +3 more
core +1 more source
Shared structural mechanisms of general anesthetics and benzodiazepines
Nature, 2020 Most general anaesthetics and classical benzodiazepine drugs act through positive modulation of γ-aminobutyric acid type A (GABA A ) receptors to dampen neuronal activity in the brain 1 – 5 .
Jeong Joo Kim +9 more
semanticscholar +1 more source
General Anesthetics Commonly Used for Laboratory Animals
Shiyan dongwu yu bijiao yixue, 2022 General anesthetics used for laboratory animals are mostly controlled drugs, and are subject to strict supervision by the competent government agency in China.
LU Xiao +5 more
doaj +1 more source
Structural interplay of anesthetics and paralytics on muscle nicotinic receptors
Nature Communications, 2023 General anesthetics and neuromuscular blockers are used together during surgery to stabilize patients in an unconscious state. Anesthetics act mainly by potentiating inhibitory ion channels and inhibiting excitatory ion channels, with the net effect of ...
Umang Goswami +3 more
doaj +1 more source
Nature Communications, 2020 Metastasis can occur following surgical resection of solid tumors and metastasis is the main cause of cancer death. The role of anesthetics used during surgery in cancer metastasis and the underlying mechanism remains largely unknown.
Ru Li, Yujie Huang, Jun Lin
semanticscholar +1 more source
The effect of lidocaine on apoptotic neurodegeneration in the developing mouse brain [PDF]
Korean Journal of Anesthesiology, 2014 BackgroundGeneral anesthetics induce neuronal apoptosis in the immature brain. Regional anesthesia using local anesthetics can be an alternative to general anesthesia.
Ji-Hyun Lee +6 more
doaj +1 more source
General Anesthetics Activate a Potent Central Pain-Suppression Circuit in the Amygdala
Nature Neuroscience, 2020 General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA suppresses pain in part by activating supraspinal analgesic circuits.
Thuy Hua +10 more
semanticscholar +1 more source
BMC Anesthesiology, 2021 Background Although general anesthetics depress spontaneous respiration, the comprehensive effect of general anesthetics on respiratory function remains unclear. We aimed to investigate the effects of general anesthetics on spontaneous respiration in non-
Xuechao Hao +3 more
doaj +1 more source
General Anesthetics on Immune System Cytokines: A Narrative Review Article
Anesthesiology and Pain Medicine, 2020 Context According to the previous studies, general anesthesia influences the immune system. Evaluating such impacts on the immune system helps to improve the management of anesthesia.
A. Jafarzadeh +4 more
semanticscholar +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source