Results 41 to 50 of about 6,404,771 (353)
Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
core +2 more sources
Regulatory Effect of General Anesthetics on Activity of Potassium Channels
Neuroscience Bulletin, 2018 General anesthesia is an unconscious state induced by anesthetics for surgery. The molecular targets and cellular mechanisms of general anesthetics in the mammalian nervous system have been investigated during past decades.
Yan Li +9 more
semanticscholar +1 more source
Inhaled Anesthetics: Environmental Role, Occupational Risk, and Clinical Use
Journal of Clinical Medicine, 2021 Inhaled anesthetics have been in clinical use for over 150 years and are still commonly used in daily practice. The initial view of inhaled anesthetics as indispensable for general anesthesia has evolved during the years and, currently, its general use ...
Mariana Gaya da Costa +2 more
semanticscholar +1 more source
High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]
, 2018 BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E. +12 more
core +1 more source
A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs
Frontiers in Veterinary Science, 2022 General anesthesia increases the production of reactive oxygen species (ROS), which can exacerbate or increase oxidative stress and thus affect the prognosis of surgical procedures.
Katerina Tomsič, Alenka Nemec Svete
doaj +1 more source
Front. Neural Circuits, 2017 There has been controversy regarding the precise mechanisms of anesthetic-induced unconsciousness, with two salient approaches that have emerged within systems neuroscience.
G. Mashour, A. Hudetz
semanticscholar +1 more source
iScience, 2023 Summary: The cellular and molecular actions of general anesthetics to induce anesthesia state and also cellular signaling changes for subsequent potential “long term” effects remain largely elusive.
Enqiang Chang +26 more
doaj +1 more source
General Anesthetic Techniques in Swine
Veterinary Clinics of North America: Food Animal Practice, 1996 General anesthesia techniques for swine can be challenging due to the animal's temperament, anatomic traits, physical condition, and the environment in which the clinician may be working. Taking these factors into consideration, this article provides specific information on preanesthetic considerations, venous catheterization, drug selection ...
Paula F. Moon, Lesley J. Smith
openaire +3 more sources
Monosynaptic Functional Connectivity in Cerebral Cortex During Wakefulness and Under Graded Levels of Anesthesia [PDF]
, 2012 The balance between excitation and inhibition is considered to be of significant importance for neural computation and cognitive function. Excitatory and inhibitory functional connectivity in intact cortical neuronal networks in wakefulness and graded ...
Diba, Kamran +4 more
core +3 more sources
Long-term effects of neonatal single or multiple isoflurane exposures on spatial memory in rats
Frontiers in Neurology, 2013 General anesthetics are neurotoxic to neonatal rodents and nonhuman primates. Neonatal exposure to general anesthetics has been associated with long-term cognitive deficits in animal models. Some data from humans are consistent with long-term deleterious
Kathy L Murphy, Mark G Baxter
doaj +1 more source