Results 51 to 60 of about 78,145 (311)

HYPOXIC BRAIN INJURY IN THE EARLY POSTOPERATIVE PERIOD (A CASE REPORT)

Русский журнал детской неврологии, 2017
The neurotoxicity of general anesthetic drugs still appears as a relevant interdisciplinary problem. All general anesthetics that are currently in use exhibit a neurotoxic effect on the brain at all stages of its development. It is impossible to evaluate
A. M. Ovezov, A. S. Kotov, M. V. Panteleeva, M. N. Borisova, G. A. Stashuk, A. V. Lugovoy, I. V. Razheva   +6 more
doaj   +1 more source

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]

, 2018
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E., Dai, Jennifer B., Daigle, Renee, Forman, Stuart A., Halpin, Elizabeth S., Jounaidi, Youssef, Marte-Oquendo, Francisco, Porco, John A., Schaus, Scott E., Trilles, Richard, Xu, Wenqing, Yang, Xiaoxuan, Yu, Buwei   +12 more
core   +1 more source

Neurotoxicity of General Anesthetics [PDF]

Anesthesiology, 2009
General anesthetics are highly lipid soluble and can dissolve in every membrane, penetrate into organelles and interact with numerous cellular constituents. Their actions have long been considered rapid and fully reversible, with the pharmacodynamic time course of anesthesia dictated solely by the pharmacokinetic profiles of anesthetic uptake and ...
Misha Perouansky, Hugh C. Hemmings, Bruno Riou   +2 more
openaire   +2 more sources

Daratumumab Treatment for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated neuropathy featuring progressive weakness, sensory deficits, and areflexia. While corticosteroids, intravenous immunoglobulin, and plasmapheresis are effective first‐line immunotherapies, a subset of patients remains treatment‐refractory.
Xueyu Zhang, Jianli Zhao, Xue Zhao, Xiaowei Hu, Zichun Xiao, Jie Wu, Xiaowen Li, Jing Xu, Yu‐Jing Li   +8 more
wiley   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

The influence of anesthetics, neurotransmitters and antibiotics on the relaxation processes in lipid membranes [PDF]

, 2007
In the proximity of melting transitions of artificial and biological membranes fluctuations in enthalpy, area, volume and concentration are enhanced. This results in domain formation, changes of the elastic constants, changes in permeability and slowing ...
Antonov V. F., Antonov V. F., Blume A., Bovill J. G., Brown D. A., Böckmann R. A., Böttner M., Cannon B., Cantor R. S., Cantor R. S., Cantor R. S., Chapman D., Cruzeiro-Hansson L., Ebel H., Ebel H., Elamrani K., Franks N., Gaus K., Gennis R. B., Genz A., Grabitz P., Gruenewald B., Halstenberg S., Halstenberg S., Heimburg T., Heimburg T., Heimburg T., Heimburg T., Heimburg T., Helms J. B., Hill T. L., Hinderliter A., Hinz H.-J., Holzwarth J. F., Holzwarth J. F., Jackson M. B., Jacobson K., Johnson M. L., Kaufmann K., Kharakoz D. P., Korlach J., Krasowski M., Lee J., Melchior D. L., Melo E. C., Mitaku S., Mountcastle D., Nagle J. F., Onsager L., Onsager L., Papahadjopoulos D., Pollakowski D., Sackmann E., Salinas D. G., Schmidt D., Seeger H., Seeger H. M., Seeger H. M., Simons K., Singer S., Steim J. M., Strehlow U., Tamura K., Thompson T., Trudell J. R., Träuble H., Tsong T. Y., Tsong T. Y., Turnheim K., Ueda I., van Osdol W. W., van Osdol W. W., van Osdol W. W., van Osdol W. W., Vaz W. L., Winter R., Yao H.   +76 more
core   +2 more sources

Trends in Dermatopolymyositis Mortality, 1999–2022: A Nationwide Population‐Based Study, United States

Arthritis Care &Research, EarlyView.
We report the national burden of dermatopolymyositis mortality over the past quarter century using the US national vital statistics data. Age‐standardized mortality rates for dermatopolymyositis decreased at an annual rate of 3.8% each year, which was higher than the annual percent decrease for deaths from all other causes.
Elizabeth Matz, Ram R. Singh
wiley   +1 more source

Effects of general anesthetics on visceral pain transmission in the spinal cord

Molecular Pain, 2008
Current evidence suggests an analgesic role for the spinal cord action of general anesthetics; however, the cellular population and intracellular mechanisms underlying anti-visceral pain by general anesthetics still remain unclear.
Yue Yun, Nauta HJ, Lin Qing, Wu Jing, Wang Yun, Fang Li   +5 more
doaj   +1 more source

​Did a Non‐Medical Biosimilar Switching Policy Cause an Increase in Non‐Biologic/Biosimilar Health Care Resource Utilization or Cost in Patients With Inflammatory Arthritis?

Arthritis Care &Research, EarlyView.
Objective This study aimed to evaluate the impact of a series of policies that mandated switching patients with inflammatory arthritis (IA) from an originator biologic to a biosimilar in British Columbia, Canada, on health care resource use and cost.
HaoHung Dang, Sandra Blitz, Nick Bansback, Michael Law, Mark Harrison   +4 more
wiley   +1 more source

Spin-Mediated Consciousness Theory: An Approach Based On Pan-Protopsychism [PDF]

, 2002
As an alternative to our original dualistic approach, we present here our spin-mediated consciousness theory based on pan-protopsychism. We postulate that consciousness is intrinsically connected to quantum mechanical spin since said spin is embedded in ...
Hu, Huping, Wu, Maoxin
core