Results 71 to 80 of about 6,244,144 (279)
Advances in Interventional Cardiology, 2021 The purpose of this review was to summarize the anti-inflammatory and immunosuppressive properties of volatile anesthetics and present their potential impact on the outcomes of major surgical procedures as well as microsurgical cases of free tissue ...
Jakub Szrama +4 more
doaj +1 more source
Molecular interactions between general anesthetics and the 5HT2B receptor
Journal of Biomolecular Structure and Dynamics, 2015 Background: Serotonin modulates many processes through a family of seven serotonin receptors. However, no studies have screened for interactions between general anesthetics currently in clinical use and serotonergic G-protein-coupled receptors (GPCRs ...
Felipe Matsunaga +5 more
semanticscholar +1 more source
Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells
FEBS Open Bio, EarlyView.Dexmedetomidine decreases insulin release and affects glucose metabolism; however, the specific mechanism remains largely unknown. This study shows clinically relevant doses of dexmedetomidine suppressed glucose‐stimulated insulin secretion. There was no significant difference in oxygen consumption rate, intracellular ATP levels, or caspase‐3/7 ...
Munenori Kusunoki +5 more
wiley +1 more source
HYPOXIC BRAIN INJURY IN THE EARLY POSTOPERATIVE PERIOD (A CASE REPORT)
Русский журнал детской неврологии, 2017 The neurotoxicity of general anesthetic drugs still appears as a relevant interdisciplinary problem. All general anesthetics that are currently in use exhibit a neurotoxic effect on the brain at all stages of its development. It is impossible to evaluate
A. M. Ovezov +6 more
doaj +1 more source
Effect of Inhalation Anesthetics on Tumor Metastasis
Technology in Cancer Research & Treatment, 2022 Many factors affect the prognosis of patients undergoing tumor surgery, and anesthesia is one of the potential influencing factors. In general anesthesia, inhalation anesthesia is widely used in the clinic because of its strong curative effect and high ...
Yixin Jing MM +5 more
doaj +1 more source
Perioperative Neurocognitive Disorder: State of the Preclinical Science. [PDF]
, 2020 The purpose of this article is to provide a succinct summary of the different experimental approaches that have been used in preclinical postoperative cognitive dysfunction research, and an overview of the knowledge that has accrued. This is not intended
Culley, Deborah J +10 more
core
Pharmacological Reviews, 2014 Alcohols and other anesthetic agents dramatically alter neurologic function in a wide range of organisms, yet their molecular sites of action remain poorly characterized.
R. Howard, J. Trudell, R. Harris
semanticscholar +1 more source
Hydrogen sulfide repairs testicular damage induced by heat stress in rats
FEBS Open Bio, EarlyView.Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo +6 more
wiley +1 more source
On the action potential as a propagating density pulse and the role of anesthetics [PDF]
, 2006 The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory.
ANDREW D. JACKSON +13 more
core +2 more sources
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source