Results 101 to 110 of about 736,541 (316)

Effect of Intravenous Anesthetics on Spontaneous and Endotoxin‐stimulated Cytokine Response in Cultured Human Whole Blood

Anesthesiology, 1998
Background Various anesthetics have been suggested to interfere with the immune system. The ability of leukocytes to express surface receptors and mediators is fundamental to a successful host defense. Therefore, the effects of intravenous anesthetics on
B. Larsen, G. Hoff, W. Wilhelm, H. Buchinger, G. Wanner, M. Bauer   +5 more
semanticscholar   +1 more source

Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles

Advanced Science, EarlyView.
Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon, Patricia Perez Schmidt, Nicolo Panini, Francesca Caruso, Martina B. Violatto, Naths Grazia Sukubo, Alberto Martinez‐Serra, Charlotte Blanche Ekalle‐Soppo, Annalisa Morelli, Giulia Yuri Moscatiello, Chiara Grasselli, Alessandro Corbelli, Fabio Fiordaliso, Joe Kelk, Laura Petrosilli, Giuseppe d'Orazio, Ruth Mateu Ferrando, Ariadna Verdaguer Ferrer, Cristina Fornaguera, Luigi Lay, Stefano Fumagalli, Sandro Recchia, Marco P. Monopoli, Laura Polito, Paolo Bigini, Giovanni Sitia   +25 more
wiley   +1 more source

Alteration of canine left ventricular diastolic function by intravenous anesthetics in vivo. Ketamine and propofol.

Anesthesiology, 1992
Diastolic function has been shown to influence overall cardiac performance significantly, but the effect of intravenous anesthetics on diastolic function has not been previously characterized in vivo.
P. Pagel, W. Schmeling, J. Kampine, D. Warltier   +3 more
semanticscholar   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Wearable Systems of Reconfigurable Microneedle Electrode Array for Subcutaneous Multiplexed Recording of Myoelectric and Electrochemical Signals

Advanced Science, EarlyView.
A reconfigurable microneedle electrode array integrated system is developed for minimally invasive and transdermal monitoring of subcutaneous electromyography, reactive oxygen species, and pH values. By assembling discrete thumbtack‐shaped microneedles into an array, the system enables multi‐parameter detection with single‐microneedle resolution.
Zhengjie Liu, Chuanjie Yao, Xingyuan Xu, Xinshuo Huang, Shuang Huang, Shantao Zheng, Tao Zhang, Yan Li, Fanmao Liu, Yuxiang Wu, Jing Liu, Hui‐jiuan Chen, Xi Xie   +12 more
wiley   +1 more source

Anesthetic Techniques and Cancer Recurrence after Surgery

The Scientific World Journal, 2014
Many of the most common anesthetics are used in surgical oncology, yet effects on cancer cells are still not known. Anesthesia technique could differentially affect cancer recurrence in oncologic patients undergoing surgery, due to immunosuppression ...
Vincenzo Fodale, Maria G. D’Arrigo, Stefania Triolo, Stefania Mondello, Domenico La Torre   +4 more
doaj   +1 more source

Effects of Inhalation versus Total Intravenous Anesthesia on Postoperative Pulmonary Complications after Anatomic Pulmonary Resection

Journal of Chest Surgery, 2022
Background: No consensus exists regarding whether volatile anesthetics are superior to intravenous anesthetics for reducing postoperative pulmonary complications (PPCs) in patients undergoing general anesthesia for surgery.
Soojin Lee, Jeong Su Cho, Eunsoo Kim, Yeongdae Kim, Jonggeun Lee   +4 more
doaj   +1 more source

Controlling Level of Unconsciousness by Titrating Propofol with Deep Reinforcement Learning [PDF]

arXiv, 2020
Reinforcement Learning (RL) can be used to fit a mapping from patient state to a medication regimen. Prior studies have used deterministic and value-based tabular learning to learn a propofol dose from an observed anesthetic state. Deep RL replaces the table with a deep neural network and has been used to learn medication regimens from registry ...
arxiv  

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Editorial: Impact of anesthetics on cancer behavior and outcome

Frontiers in Pharmacology, 2022
Jui-An Lin, Jui-An Lin, Jui-An Lin, Jui-An Lin, Jui-An Lin, Jui-An Lin, Jui-An Lin, Daqing Ma, Szu-Yuan Wu, Szu-Yuan Wu, Szu-Yuan Wu, Szu-Yuan Wu, Szu-Yuan Wu, Szu-Yuan Wu   +13 more
doaj   +1 more source